nephjc.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

CAPTIVATE= phase 3, adaptive, platform RCT #NephTrials #NephJC 🎯 Find the best treatment, or combo, that 🐌 CKD progression ✍️Blog @nephroseeker.medsky.social @sayalibthakare.bsky.social ‪ @dramiliflores.bsky.social Reviewed by @hswapnil.medsky.social , S. Kotwal www.nephjc.com/news/nephtri...

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⏰ Happening in 3 and a half hours Let's talk methodology 😉 🔥 This trial will CAPTIVATE any nephrologist: it's a multi-centre, phase 3, adaptive, and platform trial #NephTrials #NephSky #MedSky

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Are you reading Everything is Tuberculosis yet? #NephJC @johngreensbluesky.bsky.social : "Infection has long exploited human biases and blind spots, wriggling its way through the paths injustice creates" "History, alas, is not merely a record of what we do, but also a record of what was done to us"

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1/10 Last #NephJC we discussed the use of nudges 🫵 #TenPostNephJC In this study e-nudges (email) were sent to general practitioners (GPs) & patients to see if the uptake of goal-directed medical therapy (GDMT) in diabetic CKD could be increased. Read the article 👇 pubmed.ncbi.nlm.nih.gov/40481660/

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1/10 Last #NephJC we discussed tacrolimus (TAC) versus mycophenolate mofetil (MMF) for the treatment of pediatric nephrotic syndrome. A first👶to👶immunosuppression study for SSNS in kids #TenPostNephJC . Read the articles 👇 pmc.ncbi.nlm.nih.gov/articles/PMC...

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T3g: #NephJC ⛔ Conducted in Denmark’s high-performing healthcare system (possible ceiling effect) ⛔Digital reach ≠ engagement (unknown if nudges were read/absorbed) ⛔ No qualitative data on why nudges failed (behavioral, inertia, or systemic barriers?) Others?

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T3f: #NephJC For the pessimists outh there: another US cardiology trial 👉43 clinics, T2D+ASCVD pts 👉Barrier assessment + care pathways + education + feedback → 3x higher GDMT prescriptions (37.9% vs 14.5%) pubmed.ncbi.nlm.nih....

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#nephjc

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If you want to stay on top of #NephJC happenings, sign up for our once a week newsletter www.nephjc.com/newsletter

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Want yourself some #NephJC merch? 🖱️Click here www.nephjc.com/merchandise/

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Signing off @NephroSeeker, Cristina Popa! #NephJC journey is still a #AliceinWonderland story for me, Alice, who absorbs NephWisdom, tames her imagination

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🙏Extremely grateful for all #NephJC editorial team 🔊Special shoutout this time to @dramiliflores.bsky.social‬ @husamjz.bsky.social , who worked on the summary, and @kidneyboy.bsky.social for reviewing 🌟 @brianrifkin.bsky.social for always being there

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It’s that time of year ☀️🏖️ Tired of reading journals & textbooks? Try our #NephJC Summer book club! “Everything is Tuberculosis” by @johngreenbluesky.bsky.social Discussion in August, giving you plenty of time 📖 Prove @kidneyboy.bsky.social wrong; that no one comes to book club

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⏩ Next #NephJC on July 8, 2025 #Medsky A late-breaker from #ERA25 www.nejm.org/doi/abs...

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Busy schedule coming for #NephJC 🗓️June 26th, 2025 #Nephtrials discussing the fascinating design of the CAPTIVATE platform clinical trial jamanetwork.com/jour... 🚀Space on twitter x.com/i/spaces/1gqGv...

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#NephJC What is your take-home message?

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T3f: #NephJC Multi-component strategies boost GDMT adoption See this US trial 👉141 clinics, 11,182 patients (CKD+T2D+HTN) 👉Personalized algorithm + practice facilitators → higher RASi use (11% vs 6%) (no hospitalization reduction) pubmed.ncbi.nlm.nih....

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T3g: #NephJC Why nudges fail in nephrology? See also, Japanese study: pubmed.ncbi.nlm.nih....

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T3e: #NephJC 🤔 Still, NOTIFY-1 trial was a success 👉Alerts for incidental coronary calcification (chest CT) 👉Included patient-specific CAC images + statin guidelines 🔑 difference: relied on validated deep learning + radiologist review pubmed.ncbi.nlm.nih....

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T3d: #NephJC In authors' defense: ⚔️ More detail = perceived as intrusive/burdensome ⚔️ Tailoring letters = impractical manpower cost

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T3c: #NephJC Missed opportunities: 👉No personalization (eGFR, UACR, diabetes status, Rx history) 👉No clear eligibility guidance per guidelines 🔶 Result: clinical inertia persisted 👉GPs may lack GDMT expertise to act even if patients inquire

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🎨 Did you think we forgot? ... No olviden revisar la versión en español traducir por @dramiliflores.bsky.social #NephJC #Medsky www.nephjc.com/news/2025/6/...

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T3b: #NephJC 💌 Nudge letter content 👉Noted updated CKD guidelines 👉Highlighted benefits of new therapies 👉Urged contacting providers, but no urgency or specifics

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T3f: #NephJC 👉Effective nudges require personalization + clear action steps ⚠️ Risk of becoming full "change-oriented" interventions ♻️ Change models: Create urgency → Communicate → Implement → Sustain

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Discussions pending ... Anyone sleeping? #NephJC

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T2n: #NephJC ⚠️GDMT prescriptions: No difference between GP intervention vs. usual care groups

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