osteoporosis-nl.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Because of this malignant narcissistic dictatorship, the US loses all its allies, becomes alone, and collapses completely…

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Chronic kidney disease–mineral and bone disorder: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. M Ketteler et al. management. Kidney International (2025) 107, 405–423; doi.org/10.1016/j.ki... …important clinical paper

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Pathophysiology of bone remodelling cycle: Role of immune system and lipids. C Parolini. Biochem Pharmacol 2025 Mar 3 tinyurl.com/mwukz5sx …fine update

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Advancements in mechanisms and drug treatments for fibrodysplasia ossificans progressiva. Zhou Yijun et al. J Zhejiang Univ tinyurl.com/ydzt74x2 …review

submitted 14 hours ago • 0 comments

How weak, stupid and servile is the White House?

submitted 14 hours ago • 0 comments

Chronic kidney disease–mineral and bone disorder: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. M Ketteler et al. management. Kidney International (2025) 107, 405–423; doi.org/10.1016/j.ki... …important clinical paper

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Musculoskeletal disease in acromegaly - Sweden 1977-2021 (n=844). C Rosendal et al. Eur J Endocrinol 2025 Mar 13: tinyurl.com/3p6sy6my … …osteoarthritis shoulder (HR: 5.25 [3.05; 9.06]), hip (HR: 3.15 [2.57; 3.87]) and knee (HR: 2.25 [1.85; 2.72]), and osteoporosis (HR: 2.13 [1.64; 2.78])

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The existing evidence for the use of extracellular vesicles in the treatment of osteoporosis: a review. Zixiang Geng et al. Int J Surg 2025 Mar 14 tinyurl.com/2wab9s2a

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Dear colleagues how do you tell your children that you let this happen without standing up?

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Same level of absence of empathy present in Moscow and White House

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The potential of creatine monohydrate supplementation in the management of osteosarcopenia. DG Candow et al. Curr Opin Clin Nutr Metab Care 2025 Feb 24 tinyurl.com/4nwykzes …positive findings … however, RCTs needed to confirm the safety and efficacy

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Keratocan -exprerssed in mature osteoblasts - improves muscle wasting in sarcopenia by promoting skeletal muscle development and fast-twitch fibre synthesis. Xu Chen et al. J Cachexia Sarcopenia Muscle 2025 Feb tinyurl.com/mrxvpwef …novel therapeutic target Osteosarcopenia

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France is calling for the US to return the Statue of Liberty because the US no longer represents the values that led France to offer the statue.

submitted 3 days ago • 504 comments

MR study establishes a direct causal link between urolithiasis and osteoporosis, independent of environmental factors. J Guo ety al. Front Endocrinol 2025 Feb 26 tinyurl.com/2jvftrtj … bone density and SHBG levels partially mediated this risk …first report

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Serum Proteomic and Metabolomic Signatures of High Versus Low Physical Function in Octogenarians. C Ubaida-Mohien et al. Aging Cell 10 March 2025 doi.org/10.1111/acel... ….fine update of cross-sectional data

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submitted 4 days ago • 61 comments

Heme metabolism mediates RANKL-induced osteoclastogenesis via mitochondrial oxidative phosphorylation. Heng Qiu et al. JBMR 12 March 2025 tinyurl.com/2kf7arut …selective inhibitor of heme biosynthesis NMPP effectively inhibited osteoclast differentiation

submitted 4 days ago • 0 comments

Oral vitD3 100000IU every 2wks monotherapy ↓disease activity in patients with clinically isolated syndrome typical for multiple sclerosis vs placebo, with low risk of adverse events. E Thouvenot et al. JAMA March 10 2025 tinyurl.com/4berytey …further studies necessary

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The potential of senolytics for treating low back pain, removing senescent cells that are implicated, as seen ex vivo and in the mouse model. www.science.org/doi/10.1126/...

submitted 5 days ago • 2 comments

Trump walks to Marine One to head to Mar-a-Lago to play golf on the taxpayers dime. This trip will cost us $3.1 million, which could be used by USAID to feed 710 starving children for a full year.

submitted 4 days ago • 1305 comments

Melatonin increased autophagy level to facilitate osteogenesis of inflamed periodontal ligament stem cells through TMEM110 signaling pathways. Xinyue Xu et al. J Pineal Res 10 March 2025 doi.org/10.1111/jpi.... …melatonin for periodontitis treatment deserves further investigation.

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Melatonin attenuates inflammatory bone loss by alleviating mitophagy and lactate production. Zexin Lin et al. Apoptosis 2025 Mar 10 tinyurl.com/27m7u6nu …potential treatment strategy against inflammatory osteogenic disorders

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Autophagy: regulating the seesaw of bone-fat balance. B Zhang et al. Front Cell Dev Biol 2025 Feb 24 tinyurl.com/mtpzfjbx ... targeting autophagy presents a promising strategy for treating metabolic disorders and restoring bone–fat balance

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New clinical trial map launched in the EU | European Medicines Agency (EMA) www.ema.europa.eu/en/news/new-...

submitted 6 days ago • 1 comment

Why is Trump waging a war on the Department of Education? Because he knows that his biggest enemies are educators and younger generations of learners who are unafraid to speak truth to power. Attacks on education are central to the fascist playbook.

submitted 6 days ago • 356 comments

Patients with end stage renal disease undergoing hemodialysis receiving EPO treatment may have an elevated risk of osteoporotic fractures. A nationwide retrospective cohort study from Taiwan, C-Y Lee et al. Osteoporos Sarcopenia 2 Dec 2024 tinyurl.com/mv4ducnn

submitted 6 days ago • 0 comments

EPO in adult mice resulted in bone loss, which was found to be associated with EPO-stimulated osteoclastogenesis via up-regulating PPARγ expression. However, bone loss induced by EPO was reversed by ZOL. X Liu et al. Mol Medicine 15 Sept 2024 tinyurl.com/2krtvucw

submitted 6 days ago • 0 comments

Osteoporosis in Men: an Overlooked Patient Population. SH Chou. Curr Osteoporos Rep 2025 Mar 7 tinyurl.com/4m6j3ye5 …fine review …men have fractures also, with greater morbidity and mortality than women …insufficient data recommendation screening?

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Introducing openRxiv: a new independent home for preprint sharing in the life sciences: openrxiv.org/introducing-...

submitted 7 days ago • 0 comments

Single-dose denosumab injection caused small significant but transient changes on bone mineral homeostasis in young infertile men. SK Yahyavi et al. BMC Medicine 7 March 2025 tinyurl.com/4czd3auv …insights from a pilot intervention study and RCT

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Denosumab stimulates spermatogenesis in infertile men with preserved Sertoli cell capacity. CH Andreassen et al. Cell Rep Med 2024 Oct 15 tinyurl.com/twbeh2tc … denosumab increases sperm concentration in infertile men with high serum anti-müllerian hormone

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A 62-year-old man presented to the ED with a 5-day history of low back pain and a 1-day history of lethargy. Imaging of the spine showed gas within L4. Read the full case details: nej.md/4i5kG5o #MedSky #Radiology #IDSky

submitted 8 days ago • 0 comments

Patients with end stage renal disease undergoing hemodialysis receiving EPO treatment may have an elevated risk of osteoporotic fractures. A nationwide retrospective cohort study from Taiwan, C-Y Lee et al. Osteoporos Sarcopenia 2 Dec 2024 tinyurl.com/mv4ducnn

submitted 8 days ago • 0 comments

EPO in adult mice resulted in bone loss, which was found to be associated with EPO-stimulated osteoclastogenesis via up-regulating PPARγ expression. However, bone loss induced by EPO was reversed by ZOL. X Liu et al. Mol Medicine 15 Sept 2024 tinyurl.com/2krtvucw

submitted 8 days ago • 0 comments

Osteoporosis in Men: an Overlooked Patient Population. SH Chou. Curr Osteoporos Rep 2025 Mar 7 tinyurl.com/4m6j3ye5 …fine review …men have fractures also, with greater morbidity and mortality than women …insufficient data recommendation screening?

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Cathepsin K inhibitors promote osteoclast-osteoblast communication and engagement of osteogenesis. P Panwar et al. MedRxiv 4 March 2025 tinyurl.com/4w7awaha …fine experiments …same effects ectosteric CK inhibitor, which could not have in vivo side effects, as ODN

submitted 9 days ago • 0 comments

Striking sexual dimorphism in human muscle ageing in 478,438 UK Biobank participants aged 40–82 yr. HE Ogden et al. MedRxiv 25 Febr 2025 tinyurl.com/4r662y65

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Earlier menopause is associated with both reduced cognitive performance and gray matter volume: a population-based cross-sectional study. N Schwarz et al. MeRxiv 24 Febr 2025 tinyurl.com/33u8ht88 …first study …however cross-sectional study

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JD Vance best watch this vid ‘cuz yesterday he bitched that his 3-yr-old was scared by a group of protesters shouting “Slava Ukraini.” The hypocrisy is staggering: This girl lost her leg in a Russian attack & is a symbol of the unyielding strength of the Ukrainian people who are fighting pure evil.

submitted 10 days ago • 496 comments

We've known about the gut-brain axis. Now we're learning about the gut-brain-lung axis whereby food intake can trigger an immune response in the airway. www.cell.com/neuron/fullt...

submitted 10 days ago • 15 comments

Dissecting the Shared Genetic Architecture of Modifiable Physical Activity and Autoimmune Diseases. M Chang et al. MedRxiv 3 March 2025 tinyurl.com/bdcx6cax … first comprehensive effort of the shared genetic architecture between physical activities and autoimmune diseases

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Epidemiology of osteoporotic ankle fractures in South Korea: a nationwide cohort study (2006–2022). Jung‑Wee Park et al. Osteoporos Int 6 March 2025 tinyurl.com/y82n5abm …incidence↑ in elderly women …ankle refracture and osteoporotic refracture rate increased while the mortality rate ↓

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PTH1 receptor agonists for fracture risk: a systematic review and network meta‑analysis. C Beaudart et al. Osteoporos Int 6 March 2025 tinyurl.com/yc8na9vv … teriparatide effectively reduce fracture risk, with abaloparatide enhanced benefits for non-vertebral and hip fractures

submitted 10 days ago • 0 comments

Evil is the absence of empathy. Trumps and his gang shows genuine incapacity to feel with their fellow men. Dare to be really brave and get rid of them, now!

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Globally, eating disorders affect 2% to 5% of individuals during their lifetime and are more common in females than males. This Review discusses eating disorders, their associated physical and mental risk factors, and treatments. https://ja.ma/43tdImn

submitted 13 days ago • 1 comment