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oxfordbiochemistry.bsky.social
The Department of Biochemistry at the University of Oxford
14 posts 473 followers 183 following
Prolific Poster

A study from the Berks lab at Oxford's Department of Biochemistry — 'A new structural paradigm for outer membrane protein biogenesis in the Bacteroidota' — provides a major breakthrough in understanding outer membrane biogenesis in this important group of organisms. Read more⬇️ bit.ly/202502-biorxiv

Congratulations to Harold Grosjean, Anthony Aimon, Storm Hassell-Hart and Warren Thompson, on their latest work appearing in @angewandtechemie.bsky.social, where small-molecule binders can be extracted directly from crude-reaction mixtures - cool! onlinelibrary.wiley.com/doi/10.1002/...

On this International Day of Women and Girls in Science, let's take a moment to remember Dorothy Crowfoot Hodgkin, winner of the 1964 Nobel Prize in Chemistry - at the time only the third woman to do so.

The Barr lab @ox.ac.uk has discovered the important role of cell division timing mechanisms in the formation of cancer. The research, funded by Cancer Research UK, provides valuable insight into how damaged cells are normally stopped from growing. ⬇️ bit.ly/202502-barr

I think we (well certainly I) don’t say the good stuff often enough, to reverse that trend - I’m hugely grateful for the excellent colleagues I have at @oxfordbiochemistry.bsky.social - really supportive & super talented- the research seminar from @dnatopologylab.bsky.social today was brilliant! 🔥

Research @oxfordbiochemistry.bsky.social @ox.ac.uk supported by the Wellcome Trust (UK) and NIH (USA) reveals essential new player in the process of deciding whether genes should be made or not. Great work @jesskelley.bsky.social @robklose.bsky.social @edimitrova.bsky.social 👏 bit.ly/202502-klose

Very nice to see the work of Matt Warren and Isak Valsson just out with Charlotte Deane, Aniket Magarkar and @garrettmm.bsky.social where we show how augementation can dramatically improve ML affinity predictions to close to FEP accuracy. rdcu.be/d88Wm

A collaborative study between @oxfordbiochemistry.bsky.social and @unibirmingham.bsky.social could identify potential avenues for improved treatment approaches for pancreatic cancer through understanding differences in prognosis between different pancreatic tumours. More...⬇️ bit.ly/202502-bashf...

Congratulations to Graduate student Yohan Arman (DPhil, Biochemistry) who is lead author of paper identifying method to discover fake vaccines, working with Vaccine Identity Evaluation (VIE) collaboration @oxfordbiochemistry.bsky.social www.st-hughs.ox.ac.uk/st-hughs-gra... #fakevaccines #bioscience

A postdoc position for someone interested in joining the fantastic team working on outer membrane protein organisation in bacteria. Based at @oxfordbiochemistry.bsky.social my.corehr.com/pls/uoxrecru...

🚨Thanks to generous support from @cancerresearchuk.org, we have multiple postdoctoral positions available in our lab (www.mardakhehlab.info) @oxfordbiochemistry.bsky.social to study ribosomes synthesis in cancer. Get in touch if you’re interested + RT and spread the word! 📣 #cancer #RNA 🚨

Start of week 3 of Term. The Department is a hive of activity.

#TuesdayReads: Lindsay Baker & Emma Silvester discuss using #molecular tagging (e.g., gold #nanoparticles) with electron #cryotomography to identify specific proteins in high-resolution biological images. 👇 @ox.ac.uk @medsci.ox.ac.uk @kavlifoundation.bsky.social @oxfordbiochemistry.bsky.social

Fabulous work from our colleagues in the Barr lab showing how the CPC binds the nucleosome! www.biorxiv.org/content/10.1...

#MeetTheLab This week, we are happy to introduce the Zitzmann Lab from @oxfordbiochemistry.bsky.social The lab focuses on developing antiviral therapies to address #HepatitisB ( #HBV), #HepatitisC ( #HCV), human immunodeficiency virus ( #HIV), #DengueVirus ( #DENV), #Ebola, and #influenza.

Had a wonderful day at @oxfordbiochemistry.bsky.social with great science chats and interactions with postdocs and PhD students. Many thanks to @sykhalid.bsky.social for having been a fantastic host!

Delighted to speak to prospective undergraduates as part of the Women & Non-binary People in STEM series - to give a taster mini tutorial and take questions on studying Biochemistry at St Anne’s College and @oxfordbiochemistry.bsky.social

EVENT: Sheldonian Series: Life Join the Vice-Chancellor for a vibrant exchange of ideas and discussion - hear from presenters exploring the planetary, technological and ethical dimensions of ‘Life’. Tues, 11 Feb 6-7.15pm Find out more & register👇 www.ox.ac.uk/news-an...

Thank you @s-lab.bsky.social for an excellent seminar today. Inspiring work on Streptomyces biology. The postdocs and PhD students benefited immensely from chatting with you too & dinner was also a lot of fun.

Charged peptides instead of phospholipids? Another multidisciplinary study - a collaboration led by Neal Devaraj at UCSD. Sims done in my lab by @conradopedebos.bsky.social Out now in Angew Chemie onlinelibrary.wiley.com/doi/10.1002/...

So seems like the group is on a roll this month! Here’s our latest work on parametrising coarse-grained models of sugars (disaccharides) by Astrid Brandner & in collaboration with Iain Smith, @pauloctsouza.bsky.social and @cg-martini.bsky.social pubs.acs.org/doi/10.1021/... #glycotime

Our SPNS2 paper is published! A massive collaboration of Resolute, Oxford CMD, Nuvisan, @oxfordbiochemistry.bsky.social, CeMM, Bayer, & Univ. of Zurich Work of many talented colleagues, including @sykhalid.bsky.social @supertifurgalab.bsky.social and numerous others www.nature.com/articles/s41...

Congratulations to Francis Barr and his team!

#MeetTheLab Introducing the Higgins Lab from @oxfordbiochemistry.bsky.social this week! Led by #KavliOxford Prof. Matt Higgins, the group studies how parasites invade, acquire nutrients, and evade immunity—guiding better vaccine design. #ParasiteBiology #VaccineResearch

This paper from the Barr lab @oxfordbiochemistry.bsky.social is 🔥. MDM2 levels fall during mitosis due to short protein half life. When cells spend too much time in mitosis, too much MDM2 degradation occurs. As a result, p53 stabilizes triggering G1 arrest. www.nature.com/articles/s41...

The department is a hive of activity again after the festive period break. We welcome back our staff and grad students to a snowy but beautiful Oxford and look forward to welcoming back our undergrads soon!

Great start of the New Year for Krys from our neighbour lab @oxfordbiochemistry.bsky.social. Have a look at his paper - www.nature.com/articles/s41...

Out in @naturecomms.bsky.social: Kris's work showing that elongation factor Spt5 suppresses DNA-directed, T tract-dependent RNAPII termination but promotes the torpedo-dependent mechanism - from the Vasiljeva lab @oxfordbiochemistry.bsky.social (not on bsky). www.nature.com/articles/s41...

A happy new year to you all

Wishing everyone who celebrates a very Merry Christmas.

Congratulations to Dr Richard Zhou! And thanks to his lovely examiners @doryenbubeck.bsky.social and Yvonne Jones for giving him a really engaging viva. Watch out for his nice paper, coming soon. A proud supervisor.

Congratulations to Kuang-Ting Ko (Higgins Lab) on passing her viva! Her thesis title is "Structural Characterisation of Antigens for Malaria Transmission-Blocking Vaccines", and her examiners were Andrew Blagborough (Cambridge University) & Clinton Lau (@BiochemOxford).

Join our team www.jansenlab.org as a @wellcometrust.bsky.social -funded postdoctoral fellow and help us discover how chromatin at human centromeres is formed and inherited. Position now open at @oxfordbiochemistry.bsky.social! See: my.corehr.com/pls/uoxrecru... for details!

In a collaboration between two labs spanning both sides of the English Channel, scientists have discovered a new way the organisation of DNA within our cells affects genes for generations bit.ly/202412-sarkies. Lead author: Max Fitz-James working with @psarkies.bsky.social & Giacomo Cavalli

At #KavliOxford, we believe science can bridge divides and unite. This year, our diverse community shares a heartfelt message of peace on earth in their own languages. 🌍✨ Wishing everyone peaceful holidays and a joyful winter season! ❄️ #PeaceOnEarth #ScienceUnites #DiversityInScience

Congratulations to Dr Kuang-Ting! Expert on the gametocyte surface and structural characteriser of transmission blocking malaria vaccine immunogens. I’m a proud supervisor today!

And here is a write-up of the study on the Departmental website @oxfordbiochemistry.bsky.social www.bioch.ox.ac.uk/article/dna-...

Publications this week featuring Biochem, Oxford labs: pubmed.ncbi.nlm.nih.gov/39638236/ pubmed.ncbi.nlm.nih.gov/39637865/ pubmed.ncbi.nlm.nih.gov/39636021/ pubmed.ncbi.nlm.nih.gov/39630873/

So we come to the end of Michalemas 2024. We wish those students travelling home today, safe journeys and to all of our students - a wonderful festive vacation. The staff have another week or two to go!

Let's kick things off with the latest iteration of the Ranes Lab! I'm grateful for having a great team! 🙌🏾

In a multidisciplinary study led by Georgina Benn and Tom Silhavy we show the role of OmpA in controlling the organisation of the outer membrane and in sharing the mechanical load. www.pnas.org/doi/10.1073/....

Heading down to @wellcometrust.bsky.social for a meeting of PhD program directors. We have been hugely grateful for 25 years support for our Structural Biology PhD program. Only this week I caught up with one of our previous students, @augustsilale.bsky.social, still making exciting discoveries!!

Check out our November publications 👉 kavli.web.ox.ac.uk/have-you-see...

Come join us! Wonderful #job opportunity to be the next director of the #Oxford University #Museum of Natural History. Just next door to @oxuniearthsci.bsky.social with very close #research and #teaching links @rosspanderson.bsky.social! 🧪⚒️🦕🐚🦆💎

Hello all. This is the Bluesky account for the Department of Biochemistry at the University of Oxford. Looking forward to engaging with our alumni, prospective students, colleagues and friends.