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paquetlab.bsky.social
3D iPSC models and CRISPR to investigate mechanisms of neurodegenerative and neurovascular disorders | Professor of Neurobiology at LMU Munich | https://isd-research.de/paquetlab
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We did it and now it is published: A highly Lewy-fold selective and quantitative Synuclein Aggregate Amplification Assay (SAA). Huge thanks to the amazing teams at MODAG GmbH, LMU Munich, and Bologna University! rdcu.be/eaISM

👋 Meet our PhD and Postdoc Representatives 💭 The voice of our PhD students and Postdocs. A point of contact for feedback, questions, criticism, and improvements. And they organize extracurricular activities! Meet @angelikadannert.bsky.social, Clara, Lis and Nathalie. 🔗 Read more: lnkd.in/dKtzshqr

Save the date for the GSCN #Conference on #stemcell #research and #translation in #Munich at @www.helmholtz-munich.de from 15 - 17 Oct 2025. Registration is open gscn-conferences.org/gscn-confere...

A man was destined for early Alzheimer’s — these genes might explain his escape https://www.nature.com/articles/d41586-025-00398-4 (Edited 8:18 via @skeetsapp.com)

📣 Deadline coming up soon! Don't forget to register for the INTERACT MUNICH 2025 conference! 📅 3 - 4 April 2025 📍 Biomedical Center (BMC), LMU 💬 Young life scientists 📝 Abstract deadline: 24.02.2025 ➡️ lnkd.in/eKcwZJwV #interact #munich #interact2025 #conference #PhD #Master #Postdoc

Big congrats to the winners, including Marvin Reich, PhD student co-supervised by our lab in a nice collab with @haasslab.bsky.social

🚀 Record year for LMU spin-offs! 🚀 230 million euros in investments for startups from LMU Munich – from quantum computing to cancer therapies. A strong signal for research & innovation! 💡 You can read about the areas from which LMU's successful spin-offs originate here: www.lmu.de/en/newsroom/...

England's NHS approves a groundbreaking gene therapy for sickle cell disease, offering new hope to thousands. Known as Exa-cel or Casgevy and developed by CRISPR Therapeutics and Vertex Pharmaceuticals www.theguardian.com/society/2025... #Healthcare #Innovation #SickleCellDisease #GeneTherapy 🧬

What is Europe PMC? 🤷‍♀️ A platform that connects you to global life science publications and preprints from trusted sources. Developed by @ebi.embl.org it’s your gateway to open science and enhanced research visibility. Discover your next research tool: www.youtube.com/watch?v=2jyY...

Cool stuff: iPSC derived patches of heart cells to treat heart failure

🌟 <interact> 2025 Registration Now Open! 🌟 Prepare to meet our fantastic keynote speakers while enjoying inspiring networking with the participants 🧬✨ Explore and celebrate the impact of our research on the world around us alongside like-minded scientists. Let the <interact>ion begin!!

🫀A research team led by Martin Dichgans explored how HDAC9 influences vascular inflammation, discovering its role in regulating the NLRP3 inflammasome and creating a targeted anti-inflammatory treatment for treating atherosclerosis. 🔗 synergy-munich.de/news-events/...

A study led by ISD researchers suggests a key mechanistic link between Aβ and tau accumulation in Alzheimer’s disease, showing that Aβ induces neuronal hyperconnectivity, thereby promoting the spread of tau pathology across interconnected brain regions. 👍 www.science.org/doi/10.1126/...

www.cell.com/immunity/ful... - 👉ISD investigators now defined a mechanism whereby HDAC9 regulates activation of the NLRP3 inflammasome and developed a targeted anti-inflammatory approach for treating atherosclerosis. #HDAC9 #cell #immunity

Full-time position is available in the Laboratory of Associate Professor Agnieszka Wlodarczyk at the University of Southern Denmark in Neuroimmunology and Cell Therapy with bioinformatic expertise. Closing date: 25th February www.dementiaresearcher.nihr.ac.uk/job/postdoc-...

Many thanks @afi-ev.bsky.social for featuring and supporting our work on #microglia in #Alzheimer disease!

Great event in Munich!

AFI wishes all researchers a successful new year! We look forward to supporting you with your #dementia research: New applications for Travel Grants, Publication Grants and International Training Grants can now be submitted. (Open for phd candidates and post docs working at german public institutes)

One more day to apply for these neurodegeneration professorships!

🚨 Respurce alert: Human Microglia Atlas (HuMicA) unravels changes in disease-associated microglia subsets across neurodegenerative conditions

Happy to share our new preprint led by Johannes Gnörich and @matthiasbrendel.bsky.social, showcasing a full ATN staging approach using a single dynamic PI-2620 scan, leveraging advanced kinetic modelling techniques www.medrxiv.org/content/10.1...

Couple of opportunities up to join the group! One at postdoc level, but open to senior support path. One research assistant role. Please share, or drop a line if you want to learn more! Or just apply! Thanks! elxw.fa.em3.oraclecloud.com/hcmUI/Candid... elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Great meeting - will also be there. Looking forward!

2024 was an exciting year in the PaquetLab! In January, our project 'Towards druggable targets in #Alzheimer’s disease through characterization of PLCG2-related pathways in #neurons and #microglia was funded by #JPND! We look forward to collaborate with JC Lambert, G Juhasz and S. Lichtenthaler!

Very happy to announce that the PaquetLab is now on Bluesky. We are excited to connect with everyone interested in our research and present updates on our work and lab activities! Our lab engineers 3-dimensional models of #human-brain-tissue and the #BBB and applies them to investigate ...