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Kidney diseases often have systemic effects, particularly affecting the cardiovascular system. Kidney function deterioration can lead to serious cardiovascular complications. Read this Review of cardiovascular abnormalities associated w/primary kidney diseases. link.springer.com/article/10.1...

submitted 5 days ago • 0 comments

Proliferative lupus nephritis is associated w/increased risk of progression to kidney failure. After initial kidney biopsy, utility & timing of subsequent biopsies is unknown. Read this Original Article on the utility of a subsequent kidney biopsy. Open Access link.springer.com/article/10.1...

submitted 6 days ago • 0 comments

Silent lupus nephritis (sLN) is the histopathological presence of nephritis in systemic lupus erythematosus (SLE) w/o clinical or biochemical kidney manifestations. Read this Original Article on 3 cases of sLN & the role of baseline kidney biopsies. link.springer.com/article/10.1...

submitted 6 days ago • 0 comments

Membranous nephropathy & idiopathic nephrotic syndrome are 2 glomerular diseases that benefit from treatment w/B-cell depleting monoclonal antibody rituximab. Read this Original Article comparing B lymphocyte profile between MN & INS pediatric patients. link.springer.com/article/10.1...

submitted 7 days ago • 0 comments

Prior studies in the CKiD (Chronic Kidney Disease in Children) cohort have shown poor blood pressure control over time. Read this Original Article on interval healthcare provider contact & BP control in children w/CKD & hypertension. link.springer.com/article/10.1...

submitted 7 days ago • 0 comments

Children w/kidney failure may have gastrointestinal comorbidities requiring laparotomy, which can complicate peritoneal dialysis (PD). Read this Original Article on PD & survival outcomes following laparotomy in children w/kidney failure in Japan. link.springer.com/article/10.1...

submitted 8 days ago • 0 comments

Read these Clinical Insights on a 16-yr-old girl w/CKD, where biopsy revealed tubulointerstitial nephropathy w/granulomas. Genetic analysis (exome sequencing) led to the diagnosis of nephronophthisis. Open Access. link.springer.com/article/10.1...

submitted 8 days ago • 0 comments

Read this Original Article on dental caries, oral hygiene & salivary characteristics in children w/CKD compared to healthy peers - a case control study. Open Access. link.springer.com/article/10.1...

submitted 11 days ago • 0 comments

Prevalence of obesity in adolescents is rising, including in those w/kidney failure. Obesity increases the risk of complications during dialysis. Read these Clinical Insights on bariatric surgery as bridging therapy to kidney transplantation. Open Access. link.springer.com/article/10.1...

submitted 12 days ago • 0 comments

Body cell mass (BCM) is an ideal indicator of nutritional status, independent of hydration, when measured by the whole body potassium counter (WBPC). Read this Original Article on BCM estimation by WBPC & its association w/PEW in Indian children w/CKD. link.springer.com/article/10.1...

submitted 13 days ago • 0 comments

Cystic fibrosis (CF) is a life-shortening multisystem disease resulting from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Read this Review of CF–related kidney disease. Open Access. link.springer.com/article/10.1...

submitted 14 days ago • 0 comments

More than half of patients w/congenital nephrotic syndrome (CNS) or infantile nephrotic syndrome (infantile NS) have a monogenic etiology. Read this Original Article on differences in kidney prognosis between CNS & infantile NS. Open Access. link.springer.com/article/10.1...

submitted 15 days ago • 0 comments

Cardiorenal syndrome (CRS) refers to dysfunction of both the heart & kidneys, & its pathology is bidirectional. Read this Review of key features of CRS & opportunities for pediatric-specific research. Free access this month. bit.ly/3Xq0PpA

submitted 15 days ago • 0 comments

Hyperkalemia is an important issue in kidney failure. Read this Original Article on predictors of hyperkalemia in children receiving maintenance dialysis & the importance of non-dietary causes of hyperkalemia & bioavailability of K+. link.springer.com/article/10.1...

submitted 18 days ago • 0 comments

Childhood-onset systemic lupus erythematosus (cSLE) is a severe lifelong & life-threatening autoimmune disease with multi-organ involvement. Read this Educ Review of cSLE & LN patient challenges, & an individualized transitional care plan. Open Access. link.springer.com/article/10.1...

submitted 18 days ago • 0 comments

Glomerular filtration rate (GFR) can be measured directly, or estimated from biomarkers like serum creatinine & cystatin C, or both. Measuring GFR in children is cumbersome. Read this Review of recent advances in measuring & estimating GFR in children. link.springer.com/article/10.1...

submitted 19 days ago • 0 comments

Today is World Kidney Day. Read this Letter to the Editors on epidemiology & risk factors of CKD; early detection of CKD in children; underlying mechanisms; potential kidney protection strategies; & multidisciplinary management. link.springer.com/article/10.1...

submitted 19 days ago • 0 comments

Asymptomatic, mild urinary tract dilatation (UTD) that does not resolve can progress in severity. Read this Original Article on increased kidney length in mild UTD & its prognostic role in non-resolution. link.springer.com/article/10.1...

submitted 20 days ago • 0 comments

Very-low-birth-weight (VLBW) infants have significant risk factors for adverse health outcomes. Read this Original Article comparing kidney function between VLBW preterm & term infants at 5–6 years of age. link.springer.com/article/10.1...

submitted 20 days ago • 0 comments

Read this Original Article on the safety & efficacy of telitacicept in children w/immunoglobulin (Ig) A vasculitis nephritis (IgAVN). A case series of children w/biopsy-confirmed IgAVN who received glucocorticoid w/or w/o a 2nd immunosuppressant. link.springer.com/article/10.1...

submitted 21 days ago • 0 comments

AI is a transformative tool in healthcare. Read this Original Article evaluating 2 AI-based language models, GPT-3.5 & GPT-4, & their ability to provide accurate & reliable clinical information in pediatric nephrology. Open Access. link.springer.com/article/10.1...

submitted 21 days ago • 0 comments

IgA nephropathy in children may progress over decades of adult life. Read this Review of adult data useful for children, w/results of the TESTING Trial, using oral methylprednisolone, & the NEFIgArd Trial, using enteric release budesonide. Open Access. link.springer.com/article/10.1...

submitted 22 days ago • 0 comments

Alveolar hemorrhage & acute glomerulonephritis characterize pulmonary-renal syndrome, in which anti-GBM & ANCA are often assessed. Read this Mgmt Dilemma of anti-GBM disease & p-ANCA-associated vasculitis w/necrotizing skin lesions in a 7-yr-old girl. link.springer.com/article/10.1...

submitted 22 days ago • 0 comments

Peritoneal dialysis is a cornerstone treatment for children w/stage 5 CKD. Recent advances in care protocols have led to a reduction in peritonitis & other infectious complications in pediatric patients on PD. Read this Educ Review for more. Open Access. link.springer.com/article/10.1...

submitted 25 days ago • 0 comments

Idiopathic nephrotic syndrome in children is the most common glomerular disease & is characterized by recurrent relapses. Read this Original Article on the PIN’SNP cohort & research program & the TwiCs design adapted to INS research in France. Open Access. link.springer.com/article/10.1...

submitted 25 days ago • 0 comments

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disorder. Pathogenic variants in PKD1 and PKD2 genes are the main causes of ADPKD. Read these Clinical Insights on long-term tolvaptan therapy in very early-onset PKD. link.springer.com/article/10.1...

submitted 25 days ago • 0 comments

Pediatric patients on hemodialysis often require IV iron therapy to replenish iron stores. Ferric carboxymaltose has a favorable safety profile & corrects iron deficiency. Read this Original Article on ferric carboxymaltose as an alternative. Open Access. link.springer.com/article/10.1...

submitted 26 days ago • 0 comments

Steroid-resistant nephrotic syndrome (SRNS) is the 2nd leading cause of CKD in childhood. Read this Original Article on predictive factors of remission states & kidney survival comparing genetic & non-genetic SRNS. Open Access. link.springer.com/article/10.1...

submitted 26 days ago • 0 comments

Kidney genetic services are being created worldwide, revolutionizing the management of suspected monogenic kidney disease. Read this Educational Review of the global efforts to integrate genomics into nephrology. Open Access. link.springer.com/article/10.1...

submitted 26 days ago • 0 comments

Pediatric palliative care (PPC) aims to improve the quality of life for children w/life-limiting conditions, such as advanced CKD. Read this Original Article on healthcare providers' experiences & barriers to PPC integration for children w/advanced CKD. link.springer.com/article/10.1...

submitted 27 days ago • 0 comments

Emergency use of Paxlovid may prevent serious SARS-CoV-2 infections in high-risk patient populations. Read these Clinical Insights on a 16-yr-old male w/steroid-resistant nephrotic syndrome who developed tacrolimus toxicity after Paxlovid therapy. link.springer.com/article/10.1...

submitted 27 days ago • 0 comments

Podocyte infolding glomerulopathy (PIG) is a rare kidney disorder characterized by the infolding of podocyte processes into the glomerular basement membrane. Read these Clinical Insights on PIG in a school-aged child in India. link.springer.com/article/10.1...

submitted 27 days ago • 0 comments

Snakebites are a significant public health problem worldwide. AKI is the main complication of snakebites, but its incidence is not well established in the pediatric population. Read this Original Article on AKI in child victims of Bothrops snakebites. link.springer.com/article/10.1...

submitted 28 days ago • 0 comments

Febrile urinary tract infections (fUTIs) are among the most common severe infections in the pediatric population. Read this Educational Review of kidney involvement in fUTIs, along w/their clinical, radiological, & biochemical presentations. Open Access. link.springer.com/article/10.1...

submitted 28 days ago • 0 comments

AKI is a serious complication of pediatric cancer treatment that increases the risk of CKD. Read this Original Article on incidence & risk factors of AKI & its association w/CKD during pediatric kidney tumor treatment. Open Access. link.springer.com/article/10.1...

submitted 28 days ago • 0 comments

Rituximab-induced serum sickness (RISS) is a rare drug complication in patients w/steroid-dependent nephrotic syndrome (SDNS). Read these Clinical Insights on low-dose obinutuzumab for SDNS complicated by recurrent RISS & anti-rituximab antibodies. link.springer.com/article/10.1...

submitted 29 days ago • 0 comments

Read this Educational Review of key ethical principles in ethical dilemmas encountered in clinical pediatric nephrology. A stepwise decision-making framework is offered, consisting of 5 questions, to respond using an ethically defensible process. link.springer.com/article/10.1...

submitted 29 days ago • 0 comments

Cardiorenal syndrome (CRS) refers to dysfunction of both the heart & kidneys, & its pathology is bidirectional. Read this Review of key features of CRS & opportunities for pediatric-specific research. Free access this month. bit.ly/3Xq0PpA

submitted 29 days ago • 0 comments

Demand for kidney retransplants in the pediatric population is increasing as children are receiving their first transplants at a younger age. Read this Original Article on 2nd kidney transplant during childhood, including risk factors for graft survival. link.springer.com/article/10.1...

submitted 39 days ago • 0 comments

Microscopic hematuria (MH) is a common finding in childhood that can be a sign of underlying genetic kidney disease. Read this Original Article on an electronic medical record approach to early diagnosis of genetic kidney disease in children w/MH. link.springer.com/article/10.1...

submitted 39 days ago • 0 comments

Pyelonephritis is the most common serious bacterial infection in pediatric patients. Read this Original Article on frequency & clinical significance of metabolic acidosis in pediatric patients w/acute E. coli pyelonephritis. Open Access. link.springer.com/article/10.1...

submitted 39 days ago • 0 comments

Genetic & genomic testing has transformed the practice of clinical nephrology, but genetic literacy & access to genetic care models remain barriers. Read this Educ Review of genomic testing for kidney disease & how to understand & apply it. Open Access. link.springer.com/article/10.1...

submitted 40 days ago • 0 comments

CKD affects up to 40% of children diagnosed w/posterior urethral valves (PUV). Read this Original Article on a risk stratification tool based on clinical variables available at presentation to predict CKD progression in children w/PUV. link.springer.com/article/10.1...

submitted 40 days ago • 0 comments

Childhood obesity is a well-known risk factor for primary hypertension. Read this Review of arm characteristics in cuff selection & conical cuffs as an alternative to commonly used cylindrical ones in BP measurement in pediatric patients w/obesity. Open Access. link.springer.com/article/10.1...

submitted 40 days ago • 0 comments

Diarrhea is a common complication after pediatric kidney transplantation & can result from infectious & non-infectious causes. Read this Educ Review of the morbidity of diarrheal illness after transplantation, common causes, & insights into its management. link.springer.com/article/10.1...

submitted 41 days ago • 0 comments

Alport kidney disease presents one of the most prevalent genetic kidney disorders. Read this Original Article on clinical & genetic features of pediatric patients w/COL4A3–5 variants & novel genetic variants. Open Access. link.springer.com/article/10.1...

submitted 41 days ago • 0 comments

CKD has been associated previously w/a decline in oral health. Read this Original Article on the oral health of children w/CKD, nephrotic syndrome, & children who received kidney transplantation. Open Access. link.springer.com/article/10.1...

submitted 41 days ago • 0 comments

Read this Original Article on age & gender characteristics of 24-h urinary protein/creatinine ratio & urinary microalbumin/creatinine ratio among Chinese children. Cutoff values accounting for age, gender, & ethnicity can ensure sensitivity & specificity. link.springer.com/article/10.1...

submitted 42 days ago • 0 comments

Bilateral renal agenesis (BEA) is a fetal anomaly leading to anhydramnios & pulmonary hypoplasia. Read this Review of the pathophysiology of BRA & rationale for serial amnioinfusions to treat pulmonary insufficiency assoc w/BRA. Free access this month. bit.ly/4hnNN3G

submitted 42 days ago • 0 comments

Disasters pose significant risks to vulnerable populations, particularly children w/chronic health conditions such as kidney disease. Read this Review of challenges faced by children w/kidney disease during & after disasters. link.springer.com/article/10.1...

submitted 42 days ago • 0 comments