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priesgo.bsky.social
Bioinformatics Scientist @ BioNTech #bioinformatics #AI #immunology #cancer #vaccines Opinions my own
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Posts 22 Comments 8

Protein language models excel at generating functional yet remarkably diverse artificial sequences. They however fail to naturally sample rare datapoints, like very high activities. In our new preprint, we show that RL can solve this without the need for additional data: arxiv.org/abs/2412.12979

submitted 75 days ago • 1 comment

Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵

submitted 75 days ago • 22 comments

Cell is happy to connect (and re-connect) with scientists across all areas of biology on Bluesky! We aim to start posting in 2025. Until then, we'll be keeping an eye out for your exciting and interesting findings... 🔬👀

submitted 75 days ago • 1 comment

One of the biggest questions we get is when will our journals be here. We thank you for your patience. You can now follow our journals with this starter pack!

submitted 75 days ago • 20 comments

It took four days from submission to publication, and nearly five years from publication to retraction. After campaigning by many, many scientists, and an investigation by Elsevier, an infamous paper on hydroxychloroquine as a COVID-19 treatment has been retracted. 🧪 www.science.org/content/arti...

submitted 76 days ago • 38 comments

Hi Bluesky community! 👋 Are you looking forward to 2025 as much as we are? 👀 We just updated our 2025 Annual Poster to include even more events for you to join, so go and have a look! ➡️ s.embl.org/poster-bl #EMBLEvents #molecularbiology #lifesciencetraining

submitted 80 days ago • 1 comment

As I mentioned three weeks ago, Jevin West and I are developing a sort of followup course to Calling Bullshit. We've got the basic scrollytelling tech worked out and now need to choose a design. We're not designers and would like to simply buy an HTML5 template if only for the colors and fonts.

submitted 80 days ago • 21 comments

What if Eroom's law, the decreasing productivity of drug discovery, is a result of aggressive accounting whereby pharma companies consider as much stuff as possible as R&D to avoid taxes? I bet eroom's law holds in movies too - where losses are built to equal move revenue

submitted 84 days ago • 1 comment

This is possibly the last thing I was missing from R in python. Thanks for that!

submitted 86 days ago • 0 comments

🎉Thrilled that #GenePT is published! We show how to create #ChatGPT embeddings of genes and #singlecell --> improve gene function prediction + cell annotation/analyses🧬 📰 www.nature.com/articles/s41... 🌐 github.com/yiqunchen/Ge... Great job Yiqun Chen! #LLM for bio.

submitted 87 days ago • 0 comments

Out in time for the #ASCB meeting an @science.org Review from Jody Rosenblatt and friends www.science.org/doi/10.1126/...

submitted 87 days ago • 1 comment

www.frontiersin.org/journals/imm... An approach to stratify AML patients in two immune groups based on expression profiles. #paper #immunology

submitted 87 days ago • 1 comment

This is so arbitrary it's laughable in retrospective

submitted 89 days ago • 0 comments

Imagine your notebook surviving for centuries to be studied by historians. This happened to transcriptions by Nicholai Miklouho-Maclay, Russian of Ukrainian Cossack descent, of a palaeontology class delivered by Ernst Haeckel (1866) This unlikely record, captures the rise of race science in Germany🧵

submitted 89 days ago • 8 comments

What are shapley interactions and why should you care about them? This is a guest post by Julia, Max, Fabian and Hubert on my newsletter Mindful Modeler. I also learned a lot from this post and definitely recommend checking out the shapiq package. mindfulmodeler.substack.com/p/what-are-s...

submitted 90 days ago • 1 comment

Timescales in Cell Biology #Cell PDF download: www.cell.com/cell/pdf/S00...

submitted 90 days ago • 0 comments

A nice analysis of different tokenization strategies (BPE, wordpiece, sentencepiece) on protein sequences. arxiv.org/abs/2411.17669

submitted 91 days ago • 1 comment

In case some mentors may want to read this. #Nature #PhD #scisky #student #mentor Source: www.researchgate.net/publication/...

submitted 99 days ago • 5 comments

Design of high specificity binders for peptide-MHC-I complexes https://www.biorxiv.org/content/10.1101/2024.11.28.625793v1

submitted 95 days ago • 0 comments

Our Herpesfolds paper is out in Nature Communications! rdcu.be/d1uM7 Congrats to Timothy Soh, @sofiaaognibene , Saskia Sanders, Robin Schaeper and Benedikt Kaufer! Have a look at our database at herpesfolds.org by Malte Kansy

submitted 97 days ago • 2 comments

Immune cells change in proportions with age - naive go down, effector go up. www.science.org/doi/10.1126/...

submitted 95 days ago • 2 comments

The danger theory of immunity strikes back... rdcu.be/d1uQN

submitted 97 days ago • 1 comment