prof-clark.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Wow. An AAV8-delivered gene therapy helps children suffering LCA4 Retinal Dystrophy, legally blind from birth, to gain measurable improvements to visual acuity. https://buff.ly/41qvNzZ Study paper published in the Lancet - https://buff.ly/4gXYFEm

submitted 19 hours ago • 0 comments

Now, this is cool. Using a donated placenta to create amnion grafts to save a mans eye after an acid attack

submitted 3 days ago • 0 comments

Register for next weeks ECN online Symposium focus on age-related macular degeneration (AMD) on the 27th Feb. 2025 at 1500 hours CET (0900 hours EST). Great speakers and round-table discussion Registration required, but open to all interested parties! https://buff.ly/40UbElU #AMD #complement

submitted 4 days ago • 0 comments

Targeting the alternative complement pathway may offer a new treatment for carotid atherosclerosis and ischemic stroke. Notably, low plasma levels of properdin are linked to long-term cardiovascular mortality. #complement #properdin https://buff.ly/4hGkJUM

submitted 5 days ago • 0 comments

A new study shows memory T cells accumulating in the inner choroid during early AMD stages, suggesting that adaptive immunosenescence may lead to chronic inflammation and the progression to geographic atrophy. #AMD #immunology https://buff.ly/4hocCMW

submitted 6 days ago • 0 comments

Really neat to see the development of a fast and reliable detection method for FH auto-antibodies. This will have a significant impact, particularly on patients suffering from aHUS and C3G. #complement #aHUS #C3G #factorh https://buff.ly/4gF3kee

submitted 6 days ago • 0 comments

The intricate mechanisms employed by bacteria to recruit complement factor H and use it to evade the immune system still fascinates me. https://buff.ly/40XoBLv #complement #lymedisease

submitted 7 days ago • 0 comments

Great study characterising one of the mouse FHR homologues (FHR-B) with very interesting similarities, and more importantly differences, to human FHR proteins. Perhaps a cautious warning against relying on mice to model FHR protein biology in disease? #complement https://buff.ly/42TQnKg

submitted 10 days ago • 0 comments

Register now for our ECN online Symposium focus on age-related macular degeneration (AMD) on the 27th Feb. 2025 at 1500 hours CET (0900 hours EST). Four great speakers and round-table discussion Registration required, but open to all interested parties! https://buff.ly/40UbElU #AMD #complement

submitted 11 days ago • 0 comments

Understanding the genetic risk around ARMS2/HTRA1 genes in AMD pathogenesis is still complex. Research shows that both reducing and over-expressing HTRA1 in the eye cause AMD-like symptoms, indicating that a balance is essential as extremes can be harmful. https://buff.ly/4gE9iMz

submitted 12 days ago • 0 comments

Q32 Bio is retaining its Bempikibart asset but has lost its phase 2 tissue-targeted complement inhibitor. Shame, as the pre-clinical data showed promise for tissue targeting, particularly in kidney indications, though it was unlikely to be useful for ocular applications.

submitted 13 days ago • 0 comments

Pretty cool to see a potassium channel modulator effectively able to reduce intra ocular pressure in multiple indications - Qlaris sees double as drug reduces eye pressure in pair of phase 2 trials

submitted 13 days ago • 0 comments

AI is clarifying pegcetacoplan's effectiveness in GA, especially near the fovea, highlighting that patient stratification is going to play a major part of effective GA treatments. #complement #AMD #AI https://buff.ly/42JF9Ib

submitted 14 days ago • 0 comments

Another Angela Armento study showing iPSC-derived RPE cells with AMD genetic risk are more vulnerable to oxidative stress, highlighting the need for therapies targeting both complement activation and RPE metabolic health.#AMD #complement #RPE https://buff.ly/411f2LJ

submitted 17 days ago • 0 comments

Really interesting approach in targeting complement over-activation in disease - silencing of Factor B (FB) gene transcription in the liver. Leads to reduced blood levels of FB, but what about the local, organ-specific, production of FB? #complement https://buff.ly/4hkpp2Z

submitted 19 days ago • 1 comment

A systems approach to understanding the interplay and regulation of the hemostatic (coagulation) and complement pathways in response to COVID-19 infection and its treatment. Fair to say, it's a bit complicated 😵‍💫 #COVID19 #complement #coagulation https://buff.ly/4aH4TqK

submitted 20 days ago • 0 comments

This cross-sectional study supports the potential value of adaptive optics ophthalmoscopy (AOO) for providing information on intermediate AMD and the development of atrophic lesions that cannot be seen in conventional imaging modalities https://buff.ly/40mnLGN

submitted 21 days ago • 0 comments

I see things are running smoothly across the pond. Just a right wing zealot who openly admits talking with Vladimir Putin now controls all personal data on US civil servants. What could possibly go wrong….? https://www.reuters.com/world/us/musk-aides-lock-government-workers-out-computer-systems-us…

submitted 23 days ago • 0 comments

Whatever you think of disease pathogenesis and drivers, therapeutic targeting of multiple pathways simultaneously is very much the way forward in a number of indications, and is very much gaining momentum in the complement modulation field. https://buff.ly/42tpmgv

submitted 24 days ago • 0 comments

Register now for our ECN online Symposium focus on age-related macular degeneration (AMD) on the 27th Feb. 2025 at 1500 hours CET (0900 hours EST). Four great speakers and round-table discussion Registration required, but open to all interested parties! https://buff.ly/40UbElU #AMD #complement

submitted 25 days ago • 0 comments

UK academic institutions have been in a bit of a state for a while, but so many lost jobs and subjects does not bode well for its recovery - especially from institutions like Cardiff and Durham. Chronic underfunding and lack of job security were top reasons for me leaving.

submitted 25 days ago • 0 comments

This seems important - "The European Medicines Agency (EMA) said on Monday it would no longer post on X and would use rival Bluesky instead"

submitted 26 days ago • 0 comments

For all the focus of inducing complement inhibition in inflammatory diseases, its worth remembering that natural complement inhibitors themselves cause problems in cancer, dampening a natural- or therapy-induced targeting/killing of tumours #cancer #complement https://buff.ly/4hmTnmC

submitted 26 days ago • 0 comments

This really is a crazy situation. I'm not convinced the new Trump administration realise the full consequences of such an all encompassing freeze to NIH activities. 'No new studies are being launched': NIH explains impact of Trump administration’s freeze

submitted 27 days ago • 0 comments

Congratulations to the new Dr. Richard Scharff, passing his viva yesterday with a thesis investigating the ocular ECM interactions of ITIH3! Very well done and many thanks to the examiners. Looking forward to seeing the data in the public domain soon....!

submitted 27 days ago • 0 comments

Early diagnosis of dementia through regular eye exams? Early detection is key to successfully treating , almost all, disease, especially ocular disease. But without an effective treatment option, would you want to know?

submitted 28 days ago • 0 comments

Once more unto the breach old friend… Ready for a day of collaborative, and student meetings in my old stomping grounds. Can’t wait to catch up with the very latest in ECM biology and immunology #manchester

submitted 28 days ago • 0 comments

Fascinating article demonstrating sex- and age- dependent differences in the ocular inflammatory response to AAVs, having implications for therapeutic application of ocular gene therapy. #AAV #genetherapy #ophthalmology https://buff.ly/3ClzSfe

submitted 31 days ago • 1 comment

Fascinating idea, that the function of complement FH may change under shear stress. Shear forces may expose normally tolerated underlying genetic variants, altering function and potentially impacting inflammatory vasculopathies. https://buff.ly/3DQdXx8

submitted 32 days ago • 0 comments

Absolutely excited to have at IOR in Tübingen Patricia Boya ! Giving a seminar on "Aging Stings: Mitophagy at the Crossroads of Neuroinflammation" 👉Febr 6, from 2.30 to 4 p.m. at HNO Lecturehall. Join us and let´s welcome her ! @unituebingen.bsky.social @tueneurocampus.bsky.social bit.ly/3WxZxbA

submitted 32 days ago • 0 comments

Yesterday, I had the honor of giving a talk at UCL‘s Institute of Ophthalmology in London on the latest findings around complement-mediated ocular immunity. Fantastic hosts and great fun. Thanks to Prof Andrew Dick and Dr David Merle for hosting #ophthalmology #AMD #complement

submitted 32 days ago • 0 comments

The World really is a small place. Never ceases to amaze me - I can commute from Central Europe to London. I’ll be in the city by 9am local time ready for a day at the UCL Institute of Ophthalmology #talk #AMD #ophthalmology

submitted 33 days ago • 0 comments

Interesting to note this longitudinal clinical study showing the importance of RPE/BrM thickening in the pathological sequence of AMD. For a long time I've been convinced that the outer blood/retinal barrier is a major site of disease pathogenesis. https://buff.ly/4acNohC

submitted 34 days ago • 0 comments

I remember a day when throwing a Sieg Heil in front of thousands of baying supporters was considered somewhat……. risqué. And this fool says his support for the AfD is Business motivated 🤦‍♂️

submitted 34 days ago • 0 comments

Elevated FHRs assoc. with disease klaxon 🚨. This time, increased FHR-1 levels over FH levels coincide with alternative pathway complement activation in Shiga toxin-associated hemolytic uremic syndrome: FHR-1may represent a promising therapeutic target https://buff.ly/4abccqe

submitted 36 days ago • 0 comments

Another study characterising Sodium Iodate models of retinal degeneration. Systemic or local delivery? Both have value, but still a sledgehammer to crack a nut..... Systemic Sodium Iodate Injection as a Model for Expanding Geographic Atrophy https://buff.ly/3WeVhgT

submitted 38 days ago • 0 comments

New Year’s resolution to hit the gym—right up there with eating kale and learning ukulele. Funny how my excuse-making gets more exercise than I do. Who knew gym memberships came with guilt? At least I've mastered lifting... the papers I still need to read from 2024. #NewYearGoals #Procrastination

submitted 39 days ago • 0 comments

An interesting approach for ocular diseases: intravitreal administration of RNAi for gene silencing. As all things - rather depends on the target gene and target cells. Bausch + Lomb pens $485M-plus biobucks pact with City Tx for RNAi eye disease work

submitted 40 days ago • 0 comments

Of all the emerging papers investigating the incidence of neovascularisation in AMD patients receiving either avacincaptad pegol or pegcetacoplan, no one mentions that the PEG formulation of the drugs may be a contributing factor 👇 https://buff.ly/3DV8WU0

submitted 41 days ago • 1 comment

Another example of how changes in extracellular matrix has adverse effects on cell and barrier function, here in the kidney, but perhaps lessons for the outer blood/retinal barrier too? Loss of the Endothelial Glycocalyx Component EMCN Leads to Glomerular Impairment

submitted 41 days ago • 0 comments

The University of Tübingen joining the mass of German institutions leaving X for pastures new. The right decision to move towards a balanced, open conversation @unituebingen.bsky.social #unituebingen #bluesky

submitted 42 days ago • 0 comments