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richardbuka.bsky.social
Haem reg interested in thrombosis. Chair of HaemSTAR. Father of 3. Founder of pathquestionbank.com Blog: http://classicalcompass.substack.com. Pod: Don't Just Read the Abstract
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We have te remain vigilant on scientific fraud. It seems quite frequent in women’s health 😢 One way to mitigate this would be having more 👀 in multicenter studies retractionwatch.com/2025/01/24/p...

Extremely interesting! Antibodies against COVID-19 receptor binding domain are also anti-PF4/heparin antibodies - frequently platelet activating. 1st report I know of showing this phenomenon. Well done to authors @versitiresearch.bsky.social, reviewers, & editors @bloodportfolio.bsky.social

**NEW EPISODE** Pleased to release the latest episode of Don't Just Read the Abstract with Pip Nicolson. We discuss Kuhne et al.'s study in @bloodportfolio.bsky.social on the treatment of TTP without the use of plasma exchange. There will be a follow-up episode with an author interview.

Very cool study in @nature.com showing transfer of mutated mitochondria from cancer cells into tumour infiltrating T cells --> impaired T cell function and association with poor response to checkpoint inhibition. www.nature.com/articles/s41...

Pleased to share this perspective on andexanet alfa, now published in @rpth.bsky.social #openaccess🔓 rpthjournal.org/article/S2475-… I cover blinding, surrogate endpoints, clinical outcomes and thrombosis. A brief 🧵

Making a mirror image of organisms doesn't sound like a good idea... Organisms made out of left handed DNA and right handed amino acids could evade our immune systems and have profound effects on the survival of life on earth. www.science.org/doi/10.1126/...

Sitting at the front for the Ernest Butler prize lectures at #ASH24. Spent last 10 reading about this remarkable physician scientist who discovered G6PD deficiency, X inactivation, Gaucher disease, pioneered BMT and coded reference manager software en.m.wikipedia.org/wiki/Ernest_...

#Ash24 #hemesky Very large datasets suggest factor 12 haploinsufficiency substantially reduce venous #thrombosis. Suggest intravascular pathological clot formation is molecularly different than extra vascular hemostatic clot formation?

Abstract submission for #ISTH2025 is OPEN! Tag someone who should definitely submit an abstract below⏬

A large prospective study from Austria shows that bleeding is more frequent and is of more relevance than generally assumed. Paper is behind a pay wall. tinyurl.com/2tf8kfv6 #cancer #bleeding

The other day, I summarised the new data on thrombotic events with andexanet alfa, presented to/by the FDA. Now, let's focus on new efficacy data A🧵

Tons of NEW DATA about andexanet, presented as part of FDA hearing last week. If you couldn’t make it through the short 6h meeting, GOOD NEWS, I’ve watched it and highlighted the important points. A🧵