rnadavid.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Manipulation of coacervate droplets with an electric field doi.org/10.1073/pnas...

submitted 1 day ago • 0 comments

Happy to share our latest paper published in Science Advances @aaas.org. Congratulations to my incredible students, Sandeep @sandeeprai.bsky.social, Roopali @roopsiek.bsky.social (co-first author), Anusha @anushasarbahi.bsky.social & Ashish @ashishjoshi.bsky.social. www.science.org/doi/10.1126/...

submitted 2 days ago • 2 comments

An opportunity to run the greatest little RNA Databases that can, Rfam & RNAcentral: embl.wd103.myworkdayjobs.com/en-US/EMBL/j... The only downside is you have to live near Cambridge in the UK.

submitted 2 days ago • 0 comments

Cryogenic electron microscopy showed for the first time that large RNA complexes can assemble without the help of proteins, expanding our understanding of RNA folding and function. www6.slac.stanford.e...

submitted 4 days ago • 0 comments

Rapid, nanoscale dynamics of individual IDPs determine bulk properties of the entire condensate, such as viscosity. Amazing work by Nicola Galvanetto & the Schuler lab! www.pnas.org/doi/10.1073/...

submitted 4 days ago • 0 comments

Pileated woodpecker #birds #wildlife

submitted 6 days ago • 1 comment

Hooray. Yesterday, my very first #Hydra paper was accepted! An exciting time for a career #Drosophilist. Big congratulations to @anaisbailles.bsky.social, who set up the Hydra system from scratch. Thanks Carl Modes for the liquid crystal theory. @mpi-cbg.de Preprint: www.biorxiv.org/content/10.1...

submitted 4 days ago • 1 comment

🚨🚨 News from the @castello-lab.bsky.social and @shabazlab.bsky.social. Our work, led by Louisa Iselin, reveals pervasive changes in the RNA-bound proteome induced by interferon. #RNA, #immunity, #interferon, #host-virus www.biorxiv.org/content/10.1...

submitted 5 days ago • 1 comment

IDPSeminars is back with another seminar this week from @sarahshammas.bsky.social and @sonia-longhi.bsky.social! Come hear about transcriptional regulation and viral pathogenesis! Thursday June 5th! PST 10 am EST 1 pm CET 7 pm! Info: idpseminars.com Signup form: forms.gle/3yCHeYvuuqLh...

submitted 5 days ago • 1 comment

New method drop: HCR-Proxy, a modular proximity labelling approach to profile local proteome composition around RNA at nanoscale, subcompartmental resolution. Thereby we resolved nested nucleolar layers and uncovered the grammar of spatial protein partitioning. www.biorxiv.org/content/10.1...

submitted 6 days ago • 1 comment

Excited to share my postdoctoral research on how neuronal #aging contributes to RNA dysfunction is now online at Nature Neuroscience! Here we find that aged neurons suffer from chronic cellular stress that compromises resiliency to new stressors🧪 www.nature.com/articles/s41...

submitted 6 days ago • 4 comments

Tau filaments (magenta here) tether to the membrane of extracellular vesicles in Alzheimer's disease patient brains 📷 Stephanie L. Fowler & Tiana S. Behr et al Benjamin Ryskeldi-Falcon & Karen E. Duff @ukdri.ac.uk @mrclmb.bsky.social @nature.com Neuroscience ➡️ bpod.org.uk/archive/2025...

submitted 6 days ago • 0 comments

Very proud of David Staněk, my first postdoctoral fellow who helped me get my own lab off to a great start 🙏... and a wonderful scientist who has thrived since 🔬🧬!

submitted 6 days ago • 0 comments

It’s the attack of Bugwatching! Today I received a dozen copies from the publisher, @princetonupress.bsky.social, and you can preorder from them, too.

submitted 10 days ago • 5 comments

Sad that #RNA2025 is almost over? Join us in August in the UK for another fun meeting on RNA! #RNAsky #RNAdecay

submitted 8 days ago • 1 comment

It's an interesting phenomenon that some of the deepest questions about how life works have become what looks like impossibly obscure molecular biology stuck right at the back of Nature, which will never get covered by the science media. Like this. /1 www.nature.com/articles/s41...

submitted 8 days ago • 10 comments

Are you looking for homologous sequences but alignments do not seem to work? SHARK is available as a webserver: compare sequences or search against precomputed IDR datasets: bio-shark.org @narjournal.bsky.social @mpi-cbg.de @csbdresden.bsky.social @poldresden.bsky.social doi.org/10.1093/nar/...

submitted 11 days ago • 2 comments

Manu Prakash (@prakashlab.bsky.social) explored microscopic worlds and initiatives to democratize science in a recent #KITP Public Lecture 🔬 Watch Recreational Biology: Topological puzzles in cell biology at youtu.be/bZ_BlGbjhuU

submitted 9 days ago • 0 comments

Just published, expansion in situ genome sequencing, where you can sequence DNA while still inside the cell, mapping its organization relative to proteins and other markers, with the help of expansion microscopy! Led by @jbuenrostro.bksy.social. www.science.org/doi/10.1126/...

submitted 9 days ago • 3 comments

Two new #postLights are out! 1️⃣ @mohjalloh.bsky.social revisits a #preLight on how mRNA localization to P-bodies depends on the cell cycle—work now published in #MolecularCell. What’s changed, what held up, and what was added? Read the comparison ⬇️ prelights.biologists.com/highlights/c...

submitted 9 days ago • 1 comment

I made a new friend while taking a break from writing. Woods Hole, MA. May, 2025. #birds

submitted 19 days ago • 1 comment

We are looking for a postdoc to study biomolecular condensates and/or mechanosensitive membrane proteins. Please help spread the news 🙏 sites.rutgers.edu/shi-lab/look...

submitted 10 days ago • 2 comments

Boom!!! 💥💥💥💥 EpiSci - 🧬 - 🧪 - Expansion in situ genome sequencing links nuclear abnormalities to aberrant chromatin regulation @Zachary D. Chiang. @Ajay S.Labade @jbuenrostro.bsky.social www.science.org/doi/10.1126/...

submitted 10 days ago • 0 comments

🐦🦃🦉🦆🦢🦅🦜🕊️🐔🐤🦚🐥I like this week's cover @science.org Arctic bird nesting traces back to the Cretaceous | Science www.science.org/doi/10.1126/... #Paleontology #Evolution #Bird #Bluesky #Arctic #Cretaceous #Ecosystems

submitted 10 days ago • 0 comments

Nucleoli as biomolecular bubble tea! Congrats to former Princeton ugrad Holly Cheng (now GS @MIT) ->Holly's senior thesis work, a close collab w Roggeveen Wang & @zs-biophys.bsky.social‬ &Stone. Come for the cool movies & stay for the viscoelasticity! www.pnas.org/doi/10.1073/pnas.2407423122

submitted 11 days ago • 1 comment

The amazing Sofia Lövestam initiated the below project, when she became interested in the vault particles that we sometimes observe in #cryoEM images of brain-derived #amyloid filaments. www.biorxiv.org/content/10.1...

submitted 11 days ago • 2 comments

A protein-DNA surface hydrogel mechanically protects the cell nucleus https://www.biorxiv.org/content/10.1101/2025.05.21.655270v1

submitted 13 days ago • 0 comments

DNA channel fluorescence intensity with overlaid object segmentation labels of chromosomes / cell nuclei in a zebrafish embryo. Acquired by Süheyla Eroglu-Kayikci on @visitech.bsky.social iSIM, labeled by student assistant Philip Kohle and rendered by PhD student Nils Friederich using @napari.org

submitted 14 days ago • 1 comment

Very excited to share our latest work in #MolCell showing NPM1 stabilizing the association of nucleolus associated domains (NADs) and recruiting G9a to establish their repressive chromatin states. www.sciencedirect.com/science/arti...

submitted 15 days ago • 4 comments

🚨Our new paper is online🚨 We use zero-distance⚡photo-crosslinking⚡to reveal direct protein-DNA interactions in living cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale of minutes. #DNA #Chromatin #Proteomics www.cell.com/cell/fulltex...

submitted 17 days ago • 2 comments

🤯 Implications for OLE RNA as a natural integral membrane RNA from Ron Breaker's lab rnajournal.cshlp.org/content/earl...

submitted 16 days ago • 1 comment

New paper "Chromatin unfolding via loops can drive clustered transposon insertion" in @biophysj.bsky.social Former postdoc Roshan Prizak & predoc Aaron Gadzekpo find that a feedback between transposon insertion and chromatin accessibility can give clustering. www.cell.com/biophysj/ful...

submitted 16 days ago • 1 comment

Modern tree-dwelling sloths are dwarf morphs of (usually) ground dwelling giant sloths 😮 reminds me the evolutionary trajectories of dinosaurs into birds. www.science.org/doi/epdf/10.... 🧪 ⚒️ #Paleobio #EvoBio #Geology

submitted 16 days ago • 0 comments

Excited our paper is out in Cell @cp-cell.bsky.social! 🧬⚡ DNA photo-crosslinking proteomics in living cells 🎯 Pinpoints protein-DNA interactions to single amino acids 🌎 Globally quantifies DNA binding for >1800 proteins at a timescale of minutes 🔗 www.cell.com/cell/fulltex... 🧵

submitted 16 days ago • 3 comments

Insane resource - peptide-level resolution of DNA interaction sites of all human proteins!! Amazing work!

submitted 16 days ago • 0 comments

It's finally here! After almost 3 years of planning, I'm thrilled to discover the literal and figurative blue skies @kitp-ucsb.bsky.social @jerelleaj.bsky.social, @zwickergroup.bsky.social, Frank Jülicher and I will kick off our program on biomolecular condensates next week!

submitted 18 days ago • 1 comment

🎉 Postdoc Yuri Hong, in the @hymanlab.bsky.social @mpi-cbg.de, received a Cross-Disciplinary Fellowship from the @hfspo.bsky.social. With her project “Mesoscale and Microscale Organization in C. elegans embryo,” she joins 50 pioneering postdocs from 25 nations. 🎉 www.mpi-cbg.de/news-outreac...

submitted 18 days ago • 1 comment

Fantastic day of science discussing pond scum! (Just kidding) Bring on day 2! #protistsonsky

submitted 20 days ago • 1 comment

Every hear of Vaults? If not, read this preprint! New from the lab, exploring novel mechanisms of RNA trafficking in neurons and what they might mean for memory. Led by stellar PhD student Mason Musgrove. #RNAsky www.biorxiv.org/cgi/content/...

submitted 20 days ago • 2 comments

Semipalmated Plover. Bombay Hook, Smyrna, DE. May, 2025. #birds

submitted 23 days ago • 1 comment

Current situation at Harvard Medical School for NIH grants view.u.hms.harvard.edu?qs=3ed8c01b9...

submitted 25 days ago • 9 comments

Some small molecules modulate protein condensation in cells, but how? Our latest work shows a possible mechanism of action of the small molecule lipoamide. This molecule prevents condensation of stress granules whose components are found as protein aggregates in ALS. www.nature.com/articles/s41...

submitted 24 days ago • 2 comments

1/ Super excited to share my first preprint from @andersshansen.bsky.social Lab! We used MINFLUX to track chromatin (H2B-Halo and Fbn2 locus) at an unprecedented 200 μs, then combined it with SPT to span μs-minutes (H2B) or SPT & Super-Res Live-Cell Imaging (SRLCI) to span μs-hours (Fbn2)

submitted 25 days ago • 1 comment