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rthepple.bsky.social
Scientist, lifelong athlete, home cook, music lover and amateur musician, husband, father, brother, son. Research interests: aging, cancer cachexia, sepsis, skeletal muscle and mitochondria. Did I mention mitochondria?
26 posts 330 followers 166 following
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From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA

submitted 2 days ago • 756 comments

Attention mitochondriacs! Mitochondrial supercomplexes by cryo-electron tomography. How can you not be blown away by how beautiful this is? Fascinating that ATP synthase is largely organized as dimers since this is one of the putative configurations of mPT pore. www.science.org/doi/10.1126/...

submitted 3 days ago • 0 comments

Yet another report on the economic value of NIH investments The indiscriminate and large cuts are illogical and harmful I am angry www.forbes.com/sites/michae...

submitted 11 days ago • 1 comment

Fascinating new work from @abigailmackey1.bsky.social onlinelibrary.wiley.com/doi/full/10....

submitted 12 days ago • 1 comment

New article alert from our group! If you have ever wondered what circulating factors associate with extremes of physical function in advanced age in humans, this provides some insights and raises plenty of questions: pubmed.ncbi.nlm.nih.gov/40059508/

submitted 14 days ago • 0 comments

Our new review on longitudinal body comp in lung cancer is now in print! journals.physiology.org/doi/full/10....

submitted 28 days ago • 0 comments

Scientists are now organizing events, called Stand Up for Science, on 7 March in Washington, D.C., and state capitals. So far, they have attracted more than 100 volunteers from some 30 states who are hoping to rally support for research as a public good. scim.ag/4328LAD

submitted 33 days ago • 2 comments

www.nature.com/articles/s41...

submitted 32 days ago • 0 comments

A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb. https://go.nature.com/41a7Zzj

submitted 32 days ago • 5 comments

@DrJimmyBagley and I wrote this while he was fighting (and beating!) cancer. Grateful for him as my colleague and friend. “A primer on global molecular responses to exercise in skeletal muscle: Omics in focus”. Cutting edge! @JSHS_MedHealth #myoblue www.sciencedirect.com/science/arti...

submitted 36 days ago • 0 comments

When studying mitochondria, it is essential to consider the impact of physical activity. Some findings attributed to 'aging' might actually be the result of decades of physical inactivity. ⬇️ www.cell.com/cell-reports...

submitted 41 days ago • 1 comment

Polyamine metabolism dysregulation contributes to muscle fiber vulnerability in ALS www.cell.com/cell-reports...

submitted 41 days ago • 0 comments

www.nature.com/articles/s41...

submitted 40 days ago • 0 comments

Skeletal Muscle Innervation: Reactive Oxygen Species as Regulators of Neuromuscular Junction Dynamics and Motor Unit Remodeling www.sciencedirect.com/science/arti...

submitted 50 days ago • 0 comments

How cool is this?!

submitted 53 days ago • 0 comments

Ever wondered how #mitochondria fragmentation comes about during #ferroptosis ? Read our new paper on Drp1-mediated promotion of ferroptotic #celldeath. Great @cecad.bsky.social collaboration with Ana Garcia Saez! rdcu.be/d7L66

submitted 55 days ago • 0 comments

Fascinating new paper relating to motoneuron changes in muscles regulating swallowing with aging. This likely has implications for limb muscle too. physoc.onlinelibrary.wiley.com/doi/full/10....

submitted 55 days ago • 0 comments

Thank you for the awesome probe, and big shout-out to @lycasworks.bsky.social for the STED wizardry ✨

submitted 59 days ago • 1 comment

Want to come work with us to understand the role of mitochondrial permeability transition in skeletal muscle? Postdoc position available at UF on the BREATHE T32 (US citizens and permanent residents eligible). breathe.phhp.ufl.edu/training/bre...

submitted 61 days ago • 0 comments

Nice summary of our paper by #AdvancedScienceNews🤩 www.advancedsciencenews.com/exercising-e... @ismcopenhagen.bsky.social #BispebjergHospital

submitted 105 days ago • 0 comments

A renewed reminder to anyone applying for a PhD or postdoc position in a lab--indicate your interest in the email/cover letter by talking a bit about that lab's work and why it would be a good fit. I answer any query that includes this information but do not answer those that do not.

submitted 109 days ago • 6 comments

AMPK regulates the maintenance and remodelling of the neuromuscular junction by @ngseany.bsky.social @mikhaiai.bsky.social @stephmattina.bsky.social www.sciencedirect.com/science/arti...

submitted 121 days ago • 0 comments