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sabersaharkhiz.bsky.social
PhD-ing Neuroscience + Machine Learning (Computational Microscopy) @uOttawaMed @OttawaHospital 🇨🇦 || Molecular Cell Biologist 🧑🏻‍🔬using genes 🧬, microscopy🔬, computer science💻 & math📊 to understand 🧠 https://saberthesaharkhiz.github.io/
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Excited to share our latest paper in #NatureReviewsCardiology on why #women are more prone to #CardiovascularDisease due to #Autoimmunity & #SsensitiveHypertension! Read more: www.nature.com/articles/s41...

AI mirrors experimental science to uncover a novel mechanism of gene transfer crucial to bacterial evolution https://www.biorxiv.org/content/10.1101/2025.02.19.639094v1

SAMCell: Generalized Label-Free Biological Cell Segmentation with Segment Anything www.biorxiv.org/content/10....

After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool. www.nature.com/articles/s41...

Our paper, Moving toward a better understanding of renal lymphatics: challenges and opportunities, is now published in #PediatricNephrology and available on #pubmed! Read more: pubmed.ncbi.nlm.nih.gov/39899153/ Thanks, Dr. Kon, for including us in this! #Nephrology #RenalLymphatics #KidneyHealth

Fruit flies have a different type of blood to us, and their insulin comes from neurons instead of pancreatic cells. But important similarities mean scientists could use them to better understand human health. https://elifesciences.org/digests/98514/a-closer-look-at-insulin-producing-cells?utm_sour…

Our newest preprint is out: an automated code-free method developed for quantifying synapses in C. elegans (but also useful for other fluorescent puncta/organisms!) that we're calling "WormSNAP" www.biorxiv.org/content/10.1... #wormfeed #neuropapers

AlphaFold (the archetype): genAI to predict 3D protein structure from amino acid sequence New ChromoGen: genAI to predict 3D genome structure from DNA sequence www.science.org/doi/10.1126/...

Microscopy Nodes is now up on bioRxiv! 🚀 This is a Blender extension that seamlessly integrates and visualizes 3D microscopy data (TIF & @zarr.dev). High-quality volume rendering for anyone, in both EM and fluorescence, regardless of computational expertise! 🔬 www.biorxiv.org/content/10.1...

Our newest paper is out! Congratulations to lead author @elisafrankel.bsky.social! www.sciencedirect.com/science/arti... #Neuroscience #WormFeed #NeuroPapers #Celegans

What if… spontaneous neural activity 🧠 reflects the baseline rumblings of a brainwide dynamical system initialized for learning? We find that the rumblings have macroscopic properties like those emerging from linear symmetric, critical systems 🧵 #neuroscience #neuroAI www.biorxiv.org/content/10.1...

Our first preprint list for 2025 is focussed on research using microscopy tools to answer questions in biology. As always, please let us know if there are other preprints that you’d like to see on our list. focalplane.biologists.com/2025/01/10/m...

It's almost #FluorescenceFriday! Here is a ~E9.5 mouse neural tube section showing the signaling protein Sonic Hedgehog (SHH,green) and the SHH-specified floor plate (marked by FoxA2, magenta). We are interested in how SHH travels from signal-producing to signal-receiving cells. 🔬 Miriam Dillard 🧪 👩‍🔬

A previous study in @plosbiology.org found that Wnt receptors are housed in early endosomes and required for dendritic #microtubule nucleation. This Update Article shows that microtubule dynamics in #dendrites can be influenced non-autonomously by surrounding epithelial cells 🧪 plos.io/3DK0M0J

bHLH genes have diverse roles during the development of the nervous system; this functional study of five #Celegans bHLH genes shows that some of them can regulate #neuropeptide secretion & significantly expand lifespan when mutated 🧪 @plosbiology.org plos.io/3W7OQMs

New Year’s Gifts 🎁 #Rumi #Persian

#TIRFSIMThursday with a COS cell labeled for actin, clathrin and microtubules

Happy sum(i**3 for i in range(10)) !

Fluid mechanics of luminal transport in actively contracting endoplasmic reticulum.

I just created my personal website, linked below and in my Bio: saberthesaharkhiz.github.io

After years of #programming (Python & R) on Windows and remote Linux servers, I’ve moved completely to #Linux/#Ubuntu on my laptop. The difference in efficiency, speed, and lightweight performance is remarkable. Highly recommend Linux for coding and development! 🤝🏼👌🏽 @ubuntu-ls.bsky.social

If you disappeared from social media today, who would notice? Who would miss you? The truth is, most of us would be forgotten faster than we think. Likes and follows are fleeting, but real impact lasts. Are you building something worth remembering, or just feeding the algorithm?

JDLL: a library to run deep learning models on Java bioimage informatics platforms. @jytinevez.bsky.social @deepIcy_IP @deepImageJ www.nature.com/articles/s41...

VNC-Dist: A machine learning-based tool for quantification of neuronal positioning in the ventral nerve cord of C. elegans https://www.biorxiv.org/content/10.1101/2024.11.16.623955v1

New in Nature Methods from Wei, Poon, and Wang: BiomedParse, a biomedical foundation model that can jointly conduct segmentation, detection and recognition across nine imaging modalities. www.nature.com/articles/s41...

Just joined Bluesky with the first bit of my PhD work! Looking forward to connecting with amazing biologists and scientists here. #Neuroscience #Machine_learning #Molecular_Cell_Biology #Developmental_Biology #Systems_Biology #PhD

Just out! Exploring the Impact of Variability in Cell Segmentation and Tracking Approaches. Published in Microscopy Research and Technique. Thanks #BBSRC for funding. see: doi.org/10.1002/jemt... @laurawiggins13.bsky.social @globias.bsky.social @eurobioimaging.bsky.social

VNC-Dist: A machine learning-based tool for quantification of neuronal positioning in the ventral nerve cord of C. elegans https://www.biorxiv.org/content/10.1101/2024.11.16.623955v1