Profile avatar
saligramalab.bsky.social
#TCR and #human diseases “We are all smart. Distinguish yourself by being kind.”—Charles Gordon. Studying T cells in brain doesn't make me a neuroimmunologist!
235 posts 503 followers 326 following
Prolific Poster
Conversation Starter

3-year #postdoc position in Bioinformatics in @immunebjorn.bsky.social at the University of Oslo and collaboratively #our #lab focusing in rheumatoid arthritis. Please see details here -Candidate will get to experience #Norway #USA labs. Must apply by #May21st lds.easycruit.com/vacancy/3490...

"platform to demonstrate that the #quality of data used to #create TCR-pMHC #prediction models is #concerningly #low" A functionally validated TCR-pMHC database for TCR specificity model development www.biorxiv.org/content/10.1...

www.science.org/doi/10.1126/...

jitc.bmj.com/content/13/5...

A rare #good #news these days for #grants - #administrative #supplement for our #grant is #awarded

After a long time seeing a nice paper on #microglia -they #can #present #antigens -question would be do these #antigens elicit any #Tcell #response? www.biorxiv.org/content/10.1...

#Retroelement-Specific Tissue Resident #TCells Control Tissue Resilience and Predisposition to Inflammation @SSRN @cellpressnews Sneak Peek papers.ssrn.com/sol3/papers....

I haven't seen this much in #real #practice though! I have accepted the fact that I am on my own with my lab!

As far as I have seen, they don’t do it. We are on our own!!

Even the #reviewers don’t care -they simply state “this #PI is #unproductive”

continuing on #crossreactivity #TCR "TCRs expressed by naive T cells are required to respond to all foreign antigens despite never having encountered them before and being unable to adapt to them at the protein sequence level" www.pnas.org/doi/10.1073/...

Continuing on #crossreactivity Structural basis for #Tcell recognition of altered peptide ligands: a single #TCR can productively recognize a large continuum of related ligands. rupress.org/jem/article-...

"Questioning is an inherently subversive activity and deeply resented in most societies"

I do not know how to #interpret this www.biorxiv.org/content/10.1...

Learn from this picture below!!

Intriguing #paper #Virus and #Dementia www.nature.com/articles/s41...

I guess it doesn’t matter if people die with #infectious #disease, #cancer and #neuro #degeneration-that’s the #message from #current #administration and #policies

Gotta #love seeing and listening to #elite and #famous #scientists all the time in #every conference. Bonus -same #story heard over and over again. Gotta #love it though!

I very happy with this restoration….lets not forget all other grants and research in every field that is being halted or dismantled

Here it is …one of our previous #tech just accepted to be in a #graduate #program. This makes me immensely #happy.

Even in #darkest #hours -there is nothing #wrong being #optimistic and #positive. Losing #HOPE is a #death #sentence

Another international student detained…why? Why? Why? Please stop.

Just F*ing watch this ...incredibly moving www.youtube.com/live/JofqSdW...

Dear #NIH #reviewers -"the #PI is #unproductive and have #not #secured an #R01 or #published #recently" -if you write these kind of reviews think again!

Clearly @thedemocratsmv.bsky.social @housedemocrats.bsky.social @senatedems25.bsky.social #Incompetence is in full #display Clearly they dont know how to fight @schumer.senate.gov @rep-jeffrieshakeem.bsky.social @kenmartin.bsky.social

Thanks to Andy and Jane Bursky and the entire Bursky Center for Unanue Prize burskycenter.wustl.edu

Perhaps also fund research/researchers all across rather than #few #elite #institutes! Talent is everywhere

Stress eating is out of control these days

Hearing from a source: "A friend at NCI lost 3 outstanding staff (their words) and tweeted about it. She was suspended for 2 days. No idea how her tweet was flagged." This is for all the people asking us why it's hard to tell what's happening at NIH. Retaliation is real.

If anything and wants to make science efficient -I would propose to get rid of #NH #reviewer #comments like this -this is essentially hilarious "The approach, conceptually, has been previously proposed"

"While our data are significant, the overall ORs are modest and range from an OR of 3.27 (EBNA1 AA381-410) and an OR of 2.63 (GlialCAM AA385-416) to an OR of 9.40 (combination of HLA-DRB1*15:01, anti-EBNA1 AA381-410, anti-GlialCAM AA365-394)"

plot thickens in a good way! www.nature.com/articles/s41...

"While our data are significant, the overall ORs are modest and range from an OR of 3.27 (EBNA1 AA381-410) and an OR of 2.63 (GlialCAM AA385-416) to an OR of 9.40 (combination of HLA-DRB1*15:01, anti-EBNA1 AA381-410, anti-GlialCAM AA365-394)"

Tomorrow is the five year anniversary of the official start of the COVID-19 pandemic

This is the exact moment when first amendment went to trash www.gsa.gov/about-us/new...

DOJ, HHS, ED, and GSA Announce Initial Cancellation of Grants and Contracts to Columbia University Worth $400 Million (government press release) www.gsa.gov/about-us/new...

60th anniversary of Bloody Sunday in #Selma #JohnLewis #necessary #trouble

Changing my writing -from TCR #diversity to #breadth of TCR repertoire

#Freedom to #succeed always involves #freedom to #fail -it’s funny and even sad that I have to mention it #outloud

How to debunk a masterclass of lies and deflection? @sanders.senate.gov x.com/sensanders/s...