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samwill.bsky.social
NNF Postdoctoral Fellow at DTU in the Weber lab Hunting for new antibiotics by hunting for novel resistance #metabolomics #genomemining #secmet
38 posts 660 followers 764 following
Prolific Poster

journals.plos.org/plosbiology/...

Important paper. This could be the missing link that mediates the effects of nitric oxide gas on sporulation and antibiotic production in Streptomyces species.

GATOR-GC preprint is live! If you haven't already, check out our new tool for targeted gene cluster mining. @jcedielbecerra.bsky.social doi.org/10.1101/2025...

BBSSRC NE England Doctoral Landscape in Biosciences (NEEDL) funded PhD studentship in my lab co-supervised by @thecopperdoctor.bsky.social & Dr James Connolly. Antibiotics from the abyss – assessing the impact of deep-sea mining on biodiscovery www.findaphd.com/phds/project... deadline 31st March!

Hello BlueSky community 👋 You can now find us @natprodreports.rsc.org Join the Natural Product Reports conversation for high impact, critical reviews in natural products research and related areas #ChemSky #natprod

I'm happy to share a correspondence in @naturemetabolism.bsky.social in which I was involved. #metabolomics #lipidomics www.nature.com/articles/s42...

It’s not every day one gets to publish an article with NASA astronauts. This journey started in 2019 and withe the goal to understand the microbial and chemical make-up of the space station. We had lots of experience with analysis from swabs on earth.

Microbiology and Metabolomics but in SPACE. The International Space Station has a unique and extreme microbial and chemical environment driven by use patterns: Cell www.cell.com/cell/fulltex...

Our minireview on BGC evolution being shaped by genomic & ecological context is now live on mSystems: journals.asm.org/doi/10.1128/... #secmet #MEvoSky

Continued Atlantic overturning circulation even under climate extremes www.nature.com/articles/s41... #jcampubs 🌊

New pre-print!!! What types of genes end up on plasmids and why? The take home message of this paper is that beneficial genes move from plasmids to chromosome, causing the ecological value of plasmids to decay over time. www.biorxiv.org/content/10.1...

🚨Postdoc position(s) alert🚨 If you like to develop new bioinformatic tools for *human* microbiome analysis, are interested by virus/phages, we (JGI Viral Genomics and Microbiome Data groups) may have a great position for you ! No official job posting yet, but email or DM if you are interested !

MassSpecGym - the first comprehensive benchmark for the discovery and identification of molecules from MS/MS data. @roman-bushuiev.bsky.social @anton-bushuiev.bsky.social @josef-sivic.bsky.social @pluskal-lab.org NeurIPS 2024 paper: arxiv.org/abs/2410.23326 #ChemSky #MassSpec #AI4Science

We will be hosting the first @mzmine.bsky.social Community Meeting at @iocbprague.bsky.social. Please register if you wish to learn about the latest developments in mzmine. More info: docs.google.com/document/d/1...

ASM stands firm in its commitment to diversity, equity and inclusion, as such efforts are critical to advancing the microbial sciences for everyone. Read our statement: asm.org/Press-Releas...

Well that’s interesting www.reuters.com/world/us/fda...

There are many large language models to choose from; some excel at coding, whereas others are better for synthesizing information https://go.nature.com/4hGYf6q

🚨 New Preprint Alert 🚨 Biosynfoni: a light-weight biosynthesis inspired molecular fingerprint! 😎 #ProudPI #CompMetabolomics www.linkedin.com/posts/jjjvan...

Cool new paper in Nature with implications for biofuel generation: A metagenomic ‘dark matter’ enzyme catalyses oxidative cellulose conversion www.nature.com/articles/s41...

📣📣Genomic data sharing: you don’t know what you’ve got (till it’s gone) www.nature.com/articles/s41... A comment @natrevgenet.bsky.social from @katholt.bsky.social and me

Interesting paper on microbial species "recombination was shown to be genome-wide and have two times or greater impact on sequence evolution than point mutations" www.nature.com/articles/s41...

Hello everyone on Bluesky! 🧪 We are EMBO, the organization of more than 2,100 leading researchers that promotes excellence in #lifesciences in Europe and beyond. Read more: www.embo.org/about-embo/m...

☎️ Calling #MEvoSky ☎️ 2x 5-year research associate / research assistant positions in experimental evolution ERC-funded project: How do mobile genetic elements and defence systems shape bacterial genome evolution? Join the friendly and exciting @mermanchester.bsky.social community in Manchester!

🚨We have a PhD position open in the Molecular Microbial Ecology group! 🚨 If you are passionate about marine natural products and novel cultivation methodologies, this will likely be of interest to you. Please apply or share far and wide 😀 efzu.fa.em2.oraclecloud.com/hcmUI/Candid...

Dorado v0.9.1 now includes a bacterial model for genome polishing, so I put it to the test! How does it compare to Medaka? And does move-table data improve polishing accuracy? Read my analysis here: rrwick.github.io/2025/02/07/d...

Machine Learning-Based Bioactivity Classification of Natural Products Using LC-MS/MS Metabolomics #JNatProd pubs.acs.org/doi/10.1021/...

If you're a non-UK scientist who wants to come to the UK for a postdoc, this year's Newton Fellowships are now open. You'll need a lab to host you (which could be me, but truly, could be any PI, so get in touch with someone you'd like to work with!) royalsociety.org/grants/newto...

Dot plots are an effective (if old school!) way to visualise the pairwise comparison of genomes. For our recent pangenomics project (rdcu.be/d8PZ7), I wrote a small Python package to produce publication ready dot plots. Check it out! github.com/drboothtj/do... pypi.org/project/dotp... 🧪🧬🦠

We are looking for a postdoc in bioinformatics interested in broad questions about the ecology and evolution of host-associated microbiomes using social bees as model. Please share with potential candidates and if interested apply here: career5.successfactors.eu/career?caree...

We have an exciting bilateral PhD scholarship between @st-andrewschem.bsky.social and Kekule Institute for Organic Chemistry at University of Bonn. In collaboration with @profphilp.bsky.social @vkrbek.bsky.social and Prof. Arne Luetzen. More info: tinyurl.com/4p3s8m4s #ChemSky #nanosky #PhD

Jobs of the year claxon

We're delighted to announce Fidele Ntie-Kang (University of Buea) as the winner of the 2025 Natural Product Reports Emerging Investigator Lectureship! 🎉 Read more about Fidele and his research here: blogs.rsc.org/np/2025/02/0... #NatProd #PlantScience

#MicroSky a whole swath of new prokaryotic genomes from soil samples...

In case you missed it. My colleague sneaked out a @biorxivpreprint.bsky.social just before Christmas with an insane amount of HQMAGs from soil using a looooot of @nanoporetech.com data. Data should be public already. Have fun 🎉 www.biorxiv.org/content/10.1...

Our mSCAPE project has been formally announced to the world by @smhopkins.bsky.social at #FOG2025 today: www.gov.uk/government/n... - a really exciting academic-public health collaboration to build a surveillance platform leveraging NHS metagenomic diagnostic data. @meerac.bsky.social

getphylo is finally official! Build phylogenetic trees directly from genbank files - at breakneck speed! I'd like to thank everyone who provided feedback and encourage you to continue. Improving getphylo doesn't stop now the paper is out! 1/5 🧪 bmcbioinformatics.biomedcentral.com/articles/10....

📢 Check out this new tool from @thombooth.bsky.social, @wemakemolecules.bsky.social and @tilmweber.bsky.social! Build phylogenies of BGCs to primates! 🙊 All you need are Gbk files of your chosen sequences. It's super fast and in my regular rotation of bioinformatic tools #phylo #secmet #micro

We began monitoring for mentions of research items on Bluesky in late October 2024. Tomorrow we will have found our millionth mention of research posted here. Here’s some brief context. 1/4

Two very nice applications of molecular networking published this week. One for natural compounds doi.org/10.1021/jacs... and one for #PFAS doi.org/10.1038/s414... @gnps2.bsky.social #teammassspec

Complete genome sequences of two actinomycetes containing abyssomicin-like gene clusters: Kutzneria buriramensis DSM 45791 and Streptomyces sp. NL15-2K by @samwill.bsky.social et al journals.asm.org/doi/10.1128/...

New online! Microbial secondary metabolites: advancements to accelerate discovery towards application

www.science.org/doi/10.1126/...

1/4 📢Now published in @ASM #MRA! Complete genomes of two actinomycetes containing abyssomicin-like gene clusters: #Kutzneria buriramensis DSM 45791 and #Streptomyces sp. NL15-2K journals.asm.org/doi/10.1128/... #secmet #microsky

Have a look at our latest study on large-scale #Streptomyces BGC mining / pangenome analysis: genomebiology.biomedcentral.com/articles/10....

Feeding 9 billion people will take lots of creativity and the best scientists. Check how Dr. Loes van Dam is working on new fungal foods are DTU biosustain. #DTU_BRIGHT www.euronews.com/health/2025/...