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sandrobottaro.bsky.social
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Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

submitted 4 days ago • 10 comments

We have a job opening at Peptone.io for an ML researcher. Come help us find new ways to understand and drug intrinsically disordered proteins (IDPs), it's a very interesting and important problem! Link in the reply ↓

submitted 32 days ago • 1 comment

Check out our recent preprint 👇on counting particles to estimate populations in #cryoem: noise can bias the estimates; with Luke Evans & a great team.

submitted 72 days ago • 0 comments

Delighted to announce that our paper "Predicting absolute protein folding stability using generative models"(lnkd.in/dZJMiY4r) has been awarded the Protein Science BEST PAPER 2024 by @proteinsociety.bsky.social.

submitted 75 days ago • 1 comment

We are sill accepting applications for poster presentations at the CECAM conference 'RNA Modelling Across Scales". Join us in the beautiful Trieste ☀️🏖️🏰! Apply now: www.cecam.org/workshop-det... Co-organized with @bussigio.bsky.social @marcodevivo.bsky.social

submitted 75 days ago • 0 comments

Our paper on prediction of phase-separation propensities of disordered proteins from sequence is now published: www.pnas.org/doi/10.1073/... The paper has been substantially updated compared to the preprint including new experimental data and using the neural network to finetune CALVADOS. 1/n

submitted 77 days ago • 1 comment

This is the moment we've worked toward for a long time: First public disclosure of the @asapdiscovery.bsky.social pan-coronavirus antiviral aiming to help keep humanity safe from future pandemic threats like MERS-CoV and other bat coronaviruses.

submitted 77 days ago • 4 comments

We’re looking for fellow nerds to help us make disordered proteins druggable. Love #IDPs, #MD, #NMR, #AI, #DrugDiscovery, or #MassSpec? Let’s talk. @bindresearch.org is hiring across the board: bindresearch.org/careers/ #compchem #compbio #NMRChat #TeamMassSpec #chemjobs @chemjobber.bsky.social

submitted 79 days ago • 0 comments

📌 Don't miss our Research Nodes #seminar this week, with Dr. @lindorfflarsen.bsky.social, from the #LinderstrømLang Centre for Protein Science (Denmark)👇 🤝 Hosted by Dr. @xsalvatella1.bsky.social   Register now! ➡️ shorturl.at/Q1LVA #BarcelonaBiomed 🧪

submitted 156 days ago • 0 comments

Conclusion of RNA assessors in #CASP16 - we are still in the “template” phase. Prediction of nucleic acids structure is still challenging for targets without templates, often relying on intuition. No big leap in accuracy since CASP15. AI based methods have not (yet?) made a major difference.

submitted 189 days ago • 0 comments

Our research presented at the @cecamevents.bsky.social workshop www.cecam.org/workshop-det...! Ivan Gilardoni will show a poster about our #python package MDrefine. See also arxiv.org/abs/2411.07798

submitted 191 days ago • 0 comments

Meet the CALVADOS RNA model Ikki Yasuda, Sören von Bülow & Giulio Tesei have parameterized a simple model for disordered RNA. Despite it's simplicity (no sequence, no base pairing) we find that it captures several phenomena that depend on the charge, stickiness and polymer properties of RNA 🧬🧶🧪

submitted 194 days ago • 4 comments