sarah-ashley.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Interesting - murine data shows that TSLP can also act on Tregs and thereby limit T2 inflammation www.science.org/doi/10.1126/... #ImmunoSky #Immunology

submitted 44 days ago • 0 comments

ANNOUNCEMENT: It is that time of the year when I start filling the guest list for @einstein_agogo on @3RRRFM. Last year we had some 150 guests from all areas of research. So if you are interested, DM me the details! PhD students and ECR/MCRs most welcome! Must be Melbourne based.

submitted 43 days ago • 0 comments

What immune (gene) pathways and cells are involved in retraining the body from active food allergy to remission (clinical unresponsiveness to allergen) during oral immunotherapy? For your reading pleasure, I present a review of the literature answering this question in patient derived samples:

submitted 43 days ago • 0 comments

Precursors of exhausted T cells are preemptively formed in acute infection At that stage early precursors show diversity; memory T cells but also cells with a phenotype, gene-expression, and epigenetic profile that resembles precursors of exhausted T cells. #ImmunoSky www.nature.com/artic... 1/3

submitted 48 days ago • 1 comment

We are here 🦋. Save the date for Oz Single Cell 2025, 23-25 May in Sydney

submitted 50 days ago • 0 comments

How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3) doi.org/10.1038/s415...

submitted 53 days ago • 7 comments

Elegant work by Jason Cyster's group "Our study demonstrates that the canonical chemoattractant receptor-ligand systems well-established for lymphocyte homeostatic trafficking to LNs are no longer the major contributors in the inflamed setting." #ImmunoSky

submitted 52 days ago • 2 comments

Happy new year folks! I've made some more free vector art at scidraw.io hope these help with your fresh presentations and figures 🤓 #SciArt #immunosky #immunology #microbiology 🧪

submitted 51 days ago • 4 comments

Delighted to share a 🧵on our recent papers: 1. Allergen-specific IgE as the main predictor of remission following 🥜 #peanut oral immunotherapy (#OIT) in kids. Younger age association primarily driven by ⏬lower levels of IgE in younger children (1/6)

submitted 51 days ago • 1 comment

#Immunology by First release now @science.org Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection https://buff.ly/3DjNQ1e By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.

submitted 68 days ago • 0 comments

#Immunology by first release now @science.org Plasma cells producing high-affinity antibodies dominate the plasma cell population through increased proliferation. https://buff.ly/3BzpLmL By Andrew MacLean, Michel Nussenzweig et al.

submitted 68 days ago • 0 comments

In the 20 years since the term “microplastics” was first coined, a growing body of research has consistently shown how pervasive and problematic the pollutants have become. A recent #ScienceReview provides an overview and the progress made in understanding #microplastics.

submitted 68 days ago • 0 comments

Calling all B and T cell enthusiasts!!!! Get in touch with @precisionvaxlab.bsky.social if you are looking for a job! She’s an incredible scientist and mentor, who really fosters a positive work environment with exciting projects that have health impact. #immunosky #academicchatter

submitted 84 days ago • 1 comment

👀⤵️ - @altmetric.com further cementing Bluesky as a platform for sharing and quantifying academic discussions. ⭐ And, as this thread demonstrates, it's been achieved with a good dose of humour, which never goes amiss in life or academia! 👏 #AcademicSky #IDSky #ImmunoSky #clinmicro

submitted 85 days ago • 0 comments

BLUESKY MEGA-THREAD Altmetric is thrilled and also LITERALLY RELIEVED to officially announce: We are now tracking research attention as it happens on Bluesky! We have been picking up posts on the site since late Oct. Our team is on Bluesky all day answering questions. Let's get into it!

submitted 85 days ago • 39 comments

An amazing opportunity to be the Nossal Professor of Immunology @wehi-research.bsky.social An adventure of a lifetime! Bonuses: Vegemite at morning tea and chocolate Tim Tams last Friday of the month. Not a bad place to live either 🌞🏖️ Additional bonus unique 🇦🇺creatures 🦘🐍🕷️🐨

submitted 86 days ago • 1 comment

More #evidence for the existence of #CD8 #Regulatory #Tcells www.nature.com/articles/s41... Check our previous paper also> #KIR+CD8+ #T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19 | Science www.science.org/doi/10.1126/...

submitted 87 days ago • 1 comment

"Fecal microbial load is a major confounder in microbiome studies." Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations. #Cell @cellpress.bsky.social Open Access www.cell.com/cell/fulltex...

submitted 87 days ago • 0 comments

EasyPubPlot: a shiny web application for rapid omics data exploration and visualization. #EasyPublishablePlotting #Shiny #R #DataExploration @biorxivpreprint.bsky.social 🧬 🖥️ www.biorxiv.org/content/10.1...

submitted 86 days ago • 0 comments

Now in #Science #Immunology: Ziang Zhu, Tuoqi Wu, Chen Yao et al at UT Southwestern show that #NRF2 suppression mediated by the #redox sensor #KEAP1 is required for optimal expansion of #CD8 #TCells during chronic antigen exposure!

submitted 88 days ago • 0 comments

Critical role for HIF2α in driving the transition from stem-like to pathogenic Th2 cells in airway inflammation www.cell.com/immunity/ful...

submitted 88 days ago • 1 comment

Infectious disease as art. Revealing label-free imaging of Borrelia burgdorferi. #MicroSky #ImmunoSky #ChronicIlnness #Lyme

submitted 90 days ago • 3 comments

Scholars of the immune system.... Nature Reviews Immunology is now here! ⚡ #ImmunoSky 🧪 #journal

submitted 91 days ago • 1 comment

We are proud to announce a collaboration with UK Biobank to create the world’s first large-scale #epigenetic dataset of 50k participants. The dataset will unlock crucial insights into how #epigenetics drives disease & the breakthroughs to treat them. Read more: nanoporetech.com/news/oxford-...

submitted 91 days ago • 1 comment

ICYMI: earlier this year in #Science #Immunology, Josh Gray, Donna Farber & al. analyzed the phenotype, transcriptome, function, & repertoire of #gdTcells in mucosal & lymphoid tissues & blood from 176 #human donors across the life span! Subjects ranged in age from just a few days to over 80 years!

submitted 90 days ago • 0 comments

Thunderstorm Asthma Alert Due to increased thunderstorm activity the @VicGovDH has increased the forecast risk of thunderstorm asthma to high in some weather districts. For current warnings and advice: emergency.vic.gov.au/prepare/?utm... . #asthma #thunderstormasthma #pollen #allergies

submitted 91 days ago • 1 comment

www.nature.com/articles/s41... 1.1 million cell reference across the #gut #scrnaseq

submitted 96 days ago • 0 comments

Computational toolbox from Human Cell Atlas. #scrnaseq #humancellatlas https://www.nature.com/articles/d41586-024-03762-y

submitted 97 days ago • 0 comments

If your #NHMRC ideas grant was unsuccessful and you have a story to share about the impact of this on your #biomedicalresearch, career, team - get in touch. Federal DOH have asked #NARF to collect stories of impact of low funding. #SaveOzScience #DiscoveriesNeedDollars #EMCRs

submitted 92 days ago • 1 comment

A must read ! 💯 Protocol explained with great analogy. 👍 "But if X was built on an open network like Bluesky is, you could easily switch providers and keep your whole audience. This is why we like to say that Bluesky is the last social account you’ll ever have to create" 🤩 #BlueSky #ATProtocol #X

submitted 93 days ago • 0 comments

Atlas of the plasma proteome in health and disease in 53,026 adults. #Cell #medBsky #SciBsky #scisky #proteome These results provide an open-access comprehensive proteome-phenome resource (proteome-phenome-atlas.com). Open Access www.cell.com/cell/fulltex...

submitted 93 days ago • 0 comments

New study with detailed phenotyping of total and allergen-specific CD4+T cells in peripheral blood and esophageal biopsies in milk allergy vs EoE. TFH13 predominant in milk allergy but not EoE #Allergy #allergyresearch #EoE #Tcells

submitted 93 days ago • 0 comments

#rstats #StatSky Want to understand/explain the results of multivariate tests for linear models? The {heplots} 📦 visualizes these as ellipsoids for hypothesis end error matrices for an lm(). V 1.7.1 now on #CRAN {candisc} 📦 shows these in simpler canonical space 🔗See: friendly.github.io/heplots/

submitted 93 days ago • 1 comment

www.nature.com/articles/s41... Single-molecule states link transcription factor binding to gene expression Deep insights into multiple facets of TF binding, accessibility & expression with biophysical models of single molecule data by Ben Doughty, Michaela Hinks, Bintu & Greenleaf labs

submitted 97 days ago • 0 comments

This week, researchers at The University of Melbourne have been awarded the Gordon Bell Prize. "The team’s breakthrough in HPC and quantum chemistry... will enable scientists to simulate drug behaviour with an accuracy that rivals physical experiments." #gordonbellprize #hpc #simulation 🧪

submitted 94 days ago • 0 comments

#cop29 - @GretaThunberg says the people in power 'about to agree to a death sentence' Liveblog 👇 www.theguardian.com/environment/...

submitted 95 days ago • 2 comments

A multi-regional human brain atlas of chromatin accessibility and gene expression facilitates promoter-isoform resolution genetic fine-mapping www.nature.com/articles/s41...

submitted 95 days ago • 0 comments

Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling https://www.nature.com/articles/s41587-024-02475-x 🧬🖥️🧪 https://gitlab.com/sanjanalab/mps (read free: https://rdcu.be/d1aiz)

submitted 95 days ago • 0 comments

Tidyplots empowers life scientists with easy code-based data visualization https://www.biorxiv.org/content/10.1101/2024.11.08.621836v1 #rstats

submitted 97 days ago • 6 comments