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scottsoderling.bsky.social
Neuroscientist-cell biologist, proteomics developer, deep learning collaborator, tackling brain disorders. PI @Duke. Chair of Cell Biology and Biochem. Founder, Triangle Protein Design. http://soderlinglab.cellbio.duke.edu
10 posts 246 followers 184 following
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Science under siege: protecting scientific progress in turbulent times journals.biologists.com/dev/article/...

submitted 9 days ago • 2 comments

Nice News & Views on our recent paper from Tim Saunders. www.nature.com/articles/s41...

submitted 9 days ago • 0 comments

Yes, everything is on fire, but also we did some neat science. Read @schreinerdrew.bsky.social’s excellent breakdown here. tl;dr: we can track learning of birdsong on a syllable-by-syllable basis, and yes, dopamine tracks better-than-recent performance, but it’s more interesting than you’d think!

submitted 9 days ago • 0 comments

Excited to share exciting new work from my former postdoc, Il Hwan Kim. His study reveals that SHANK3, an ASD-risk gene, is expressed in brain endothelial cells and plays a crucial role in maintaining tight junction integrity at the blood-brain barrier. www.nature.com/articles/s41...

submitted 10 days ago • 0 comments

A nation that turns its back on science risks losing its humanity, today’s funding cuts are tomorrow’s crises.

submitted 13 days ago • 0 comments

www.americanprogress.org/article/how-...

submitted 22 days ago • 0 comments

Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence

submitted 37 days ago • 299 comments

Our paper, led by @argo-mkhrji.bsky.social and @woonyunghur.bsky.social, on cortical migration of nuclei in drosophila embryos came out today in @naturephysics.bsky.social. Argo wrote a comprehensive thread below. A great collaboration with Massimo Vergassola and @streichan.bsky.social.

submitted 24 days ago • 1 comment

Folks are always surprised to learn that NVIDIA has been working on a foundation model for cell segmentation called Vista 2D that can be trained on a variety of cell imaging outputs, including brightfield, phase-contrast, fluorescence, confocal, or electron microscopy. Blog in thread 🧵

submitted 56 days ago • 1 comment

Two major life updates: - I'm moving to Senior Applied Research Scientist in Digital Biology at NVIDIA (Jan '25) - I'm starting a new lab at Duke as Visiting Assistant Prof (early '25) Both roles focus on tackling hard problems in biological machine learning through collaborative research. Long 🧵

submitted 88 days ago • 16 comments

AbMAP, our work on adapting PLMs for antibodies, is now out in @pnas.org A veritable zoo of PLMs now exists, so why should you care? Well, AbMAP reflects an opinionated design philosophy about antibody representation. And based on your needs, it may be a great fit! 1/ www.pnas.org/doi/10.1073/...

submitted 78 days ago • 1 comment

Truly honored that our work was highlighted as one of many applications where #Alphafold has had an enormous impact

submitted 102 days ago • 3 comments

Google’s quantum computer chip called Willow, needed less than five minutes to perform a mathematical calculation that one of the world’s most powerful supercomputers could not complete in 10 septillion years, a length of time exceeding the age of the known universe. www.nytimes.com/2024/12/09/t...

submitted 102 days ago • 0 comments

Amazing AI tool by Rohit Singh's lab at Duke. Shrink or Supersize your protein and retain functions- all based on protein language models.

submitted 103 days ago • 0 comments

We are hiring a Director for the Carolina Institute for Neurodevelopmental Disorders. This is a highly prestigious position and a great opportunity for a leader! This could be you! unc.peopleadmin.com/postings/286...

submitted 117 days ago • 1 comment

Been talking about exploring active learning for some projects. EVOLVEPro suggests we really should. www.science.org/doi/10.1126/...

submitted 120 days ago • 0 comments

The big one is out! So over the moon to see our latest work with Stéphane Vassilopoulos published in Science. Check out how we reveal the unique architecture of clathrin-coated pits and endocytosis at the axon initial segment: www.science.org/doi/10.1126/...

submitted 211 days ago • 2 comments

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!

submitted 124 days ago • 18 comments

🚀 Big updates from our lab! We’re diving into deep learning for protein design and proteomics. For a glimpse of what’s ahead, check out our recent collab with Rohit Singh’s lab, which used AI to shrink proteins! 😱 Read more: www.biorxiv.org/content/10.1... @rohitsingh8080.bsky.social

submitted 125 days ago • 0 comments

Bsky only: 🌟 Excited to share our latest research, now out in eLife! Using advanced mass spectrometry and genetic engineering, we demonstrate presynaptic Rac1's crucial role in working memory. 🧠 Dive into the details here: doi.org/10.7554/eLif... #Neuroscience

submitted 125 days ago • 0 comments

🚨 Exciting news from our lab! Our latest paper is out in Nature Communications ↪️We developed a scalable CRISPR-based method to map native protein-protein interactions in the brain, revealing new insights into the molecular networks underlying autism. Read more here: doi.org/10.1038/s414...

submitted 125 days ago • 0 comments