sergiuppasca.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Outstanding conference at the @humantechnopole.bsky.social Many thanks to the host-organizers!

submitted 3 days ago • 1 comment

Thank you!

submitted 4 days ago • 0 comments

Fabulous #neurogen25 keynote lecture by @sergiuppasca.bsky.social in Milan this evening. Sergiu weaved a truly inspiring narrative of progress in the field of brain organoids, crediting many brilliant students & postdocs in his lab, and highlighted key questions on the horizon for psychiatry 👏👏 🧪🧫🧠

submitted 4 days ago • 2 comments

Time to celebrate two more postdocs from the Pasca lab who are departing this month to start their own groups– at Johns Hopkins and in Shanghai. Warmest congratulations Xiao & Jin, and all the best! Traditional selfie at our lab party with a now classical #assembloid cake (not shown).

submitted 4 days ago • 0 comments

A superb discovery! Congratulations!

submitted 10 days ago • 1 comment

This is a bittersweet week as we say goodbye to a phenomenal postdoc in the lab— Xiangling Meng—who is leaving to start her own independent lab at Baylor College of Medicine.

submitted 11 days ago • 1 comment

Great overview of recent work from the lab on assembloids and applications to studying sensory dysfunction in neurodevelopmental disorders. Thank you BBRF for your support over the years!

submitted 16 days ago • 0 comments

This week we welcome on campus 2025 class of students for our hands-on Stanford Brain Organogenesis course. With students joining from across the globe, this is our most international class yet—diving into cutting-edge neural #organoid and #assembloid methods, ready to bring them back to their labs.

submitted 17 days ago • 1 comment

Honored to work with @sergiuppasca.bsky.social on this review of methods to model neuropsychiatric disorders

submitted 18 days ago • 1 comment

What human experimental models do we currently have to study brain disorders—and where do they fall short? In our recent @annualreviews.bsky.social, @rebeccalevymdphd.bsky.social and I examine the landscape of human stem cell models—2D systems, 3D #organoids, #assembloids, and transplantation.

submitted 18 days ago • 1 comment

The de-extinction of the dire wolves? "Colossal Baloney"— @stemcells.bsky.social www.latimes.com/business/sto... @latimes.com by @hiltzikm.bsky.social

submitted 27 days ago • 5 comments

New from Dr. @sergiuppasca.bsky.social's lab: four-part #assembloids that model the neural sensory pathway! Read the @nature.com paper from Drs. Ji-il Kim, Kent Imaizumi, and the team: go.nature.com/3RLmd56 Listen to the episode: bit.ly/42QHFvW

submitted 36 days ago • 0 comments

Thank you for the great summary and outlooking perspective on our recent work!

submitted 36 days ago • 0 comments

The deadline for the @cshlmeetings course on #autism spectrum disorder is approaching. This was my entry into the field more than 15 years ago. While this will be my final year co-organizing it, I am looking forward to the stimulating discussions in the beautiful Banbury Center. More details 👇

submitted 37 days ago • 2 comments

It has taken decades to get to this point, but stem cells for Parkinson's disease showing promise in 2 clinical trials nature.com/articles/d41... nature.com/articles/s41... nature.com/articles/s41...

submitted 38 days ago • 6 comments

Great summary on @npr.org by Jon Hamilton discussing the recent reconstruction of the sensory neural pathway in #assembloids reported this week by our Director @sergiuppasca.bsky.social lab at @stanfordmedicine.bsky.social www.npr.org/sections/sho...

submitted 43 days ago • 0 comments

Brief overview in @data.ft.com of recent work to build four-part assembloids as a model of the human somatosensory neural pathway www.ft.com/content/f8d5...

submitted 44 days ago • 0 comments

The @sergiuppasca.bsky.social group functionally assembled the essential components of the human sensory pathway in a compound organoid "assembloid." The model could accelerate our understanding of sensory circuits and facilitate therapeutic development. ow.ly/BZ4R50VxSfy 🧪 @gregscherrer.bsky.social

submitted 44 days ago • 0 comments

Item 1 in Science in Action this week - some formidable stem-cell engineering unpicking the way pain gets transmitted through our nervous systems. Future work will test better painkillers and hyper/hypo-pain sensitivity @sergiuppasca.bsky.social tells me.

submitted 44 days ago • 1 comment

Thank you 🙏

submitted 45 days ago • 0 comments

In @nature.com today we report sensory #assembloids comprising four parts to recapitulate aspects of the pathway that processes pain stimuli and we use it to study genetic syndromes. Work pioneered by the brilliant Ji-il Kim & Kent Imaizumi in close collab with @gregscherrer.bsky.social ! Link 👇

submitted 45 days ago • 3 comments

As we approach the limits of what can be modeled in vitro, we’ll learn how much of brain organogenesis is influenced by factors outside the human body and how complex human circuits can be created in live organisms, writes @sergiuppasca.bsky.social. www.thetransmitter.org/human-neurot...

submitted 46 days ago • 0 comments

Thank you for providing this needed clarifying perspective!

submitted 46 days ago • 0 comments

It's not a dire wolf. It's a gray wolf clone with 20 dire-wolf gene edits, and with some dire wolf traits. And here's my story! Gift link: www.nytimes.com/2025/04/07/s...

submitted 47 days ago • 71 comments

Honored to be giving a Plenary in Edinburgh at the @ukdri.ac.uk on human stem cell models of disease. Such an enthusiastic group of students and trainees 🙏

submitted 48 days ago • 0 comments

As stem cell-based modeling of the human nervous system and disease advances, we recently shared a group-effort framework in @nature.com on designing experiments with #organoids, #assembloids, and transplantation Here a few key takeaways in 6 slides👇

submitted 50 days ago • 1 comment

Grateful to my amazing lab and collaborators whose dedication makes this work possible. Thrilled to continue advancing human stem cell models of the nervous system to develop effective therapeutics.

submitted 53 days ago • 0 comments

Check out this brief overview of human stem cell models and their promise in the @thetransmitter.org.web.brid.gy #hipscells #stemcells #organoids #assembloids #braindisorders

submitted 54 days ago • 2 comments

The best 2024 article about evolution, medicine and public health will win the $5000 Omenn Prize. Nominate an article now. It is easy. And the winner-and all of us- will REALLY appreciate it! isemph.org/Omenn-Prize 🧪E. #EvMed @evmed.bsky.social @tricem.bsky.social @sse-evolution.bsky.social

submitted 69 days ago • 0 comments