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shihcheng.bsky.social
Data Science | Computational Biology | Drug Discovery | Passionate about advancing genomics and biobank research through collaboration. Opinions are my own. Previously on X: x.com/ShihchengGuo
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Repurposed drugs offer new hope for Alzheimer's (AD) & other neurodegenerative disorders (NDDs). Computational tools & "omics" aid in finding candidates. #NeuroInnovation PMID:39971900, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56690-4 🧪

submitted 5 hours ago • 0 comments

Scalable cultured fish fillets: Edible porous microcarriers, muscle SCs, and adipose ASCs boost 3D tissue growth. Revolutionizing protein with cellular agriculture! #FoodTech PMID:39966507, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-57015-1 🧪

submitted 6 hours ago • 0 comments

Discover the role and regulation of bioactive lipids: FAHFAs! Key for metabolic health, measured in samples, with a focus on gene regulation. #LipidScience PMID:39875587, Nat Chem Biol 2025, @nchembio https://doi.org/10.1038/s41589-024-01827-7 🧪

submitted 7 hours ago • 0 comments

New study: METTL14 regulates m<sup>6</sup>A in brown vs. white fat, impacting metabolism divergently. Key findings in insulin resistance! #AdiposeResearch 🌟 PMID:39788955, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-024-55694-w 🧪

submitted 8 hours ago • 0 comments

Discover how a conformation strengthening antibody targeting P-cadherin can trigger cadherin endocytosis using biophysical, biochemical, & cell biological methods! #CancerScience PMID:39881179, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56478-6 🧪

submitted 9 hours ago • 0 comments

Intratumour oxidative hotspots drive cancer cell spread. T-AP1 probe reveals H₂O₂ microenvironments as key to tumour heterogeneity. New insights into metastasis! #CancerResearch PMID:39984655, Nat Cell Biol 2025, @NatureCellBio https://doi.org/10.1038/s41556-025-01617-w 🧪

submitted 10 hours ago • 1 comment

Explored 14M fragments via docking for DNA repair target OGG1, surpassing traditional limits of fragment screening. Innovation in drug discovery! #DrugDiscoveryRevolution PMID:39966348, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56893-9 🧪

submitted 11 hours ago • 0 comments

Introducing MUSK: a novel AI model integrating multimodal data for precision oncology. Transforms clinical notes and pathology data. Revolutionizing clinical care! #PrecisionOncology PMID:39779851, Nature 2025, @Nature https://doi.org/10.1038/s41586-024-08378-w 🧪

submitted 11 hours ago • 5 comments

New algorithm OM2BFB deciphers BFB-driven oncogene amplification via optical genome mapping, revealing impact on heterogeneity, treatment, survival in cancer. #CancerResearch PMID:39929823, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56670-8 🧪

submitted 11 hours ago • 1 comment

Unlocking cancer treatments: language models reveal potent kynureninases to target L-kynurenine, improving immune response #CancerImmunotherapy PMID:39777462, Nucleic Acids Res 2025, @NAR_Open https://doi.org/10.1093/nar/gkae1245 🧪

submitted 12 hours ago • 0 comments

Engineered Cas9-BD revolutionizes Streptomyces genome edits! With N- & C-terminal polyaspartate tags, off-target effects plunge, boosting metabolite yield! 🔬 #BiotechBreakthrough PMID:39833194, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56278-y 🧪

submitted 12 hours ago • 0 comments

Charged substrates boost T cell cancer therapy! Electrically stimulated CD8<sup>+</sup> T cells show enhanced persistence and tumor suppression. 1 study, infinite potential! #Immunotherapy PMID:39939595, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56858-y 🧪

submitted 13 hours ago • 0 comments

New study: An mRNA vaccine with a truncated pre-F protein enhances RSV protection! Young & old models show promise. #InnovationInVaccines PMID:39910047, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56302-1 🧪

submitted 14 hours ago • 1 comment

Study on a Neural Conversational Agent for weight loss shows potential in delivering Motivational Interviewing (MI) support without costly provider training, targeting obesity, a costly chronic disease. #WeightLossTech PMID:39303273, JMIR Res Protoc 2024 https://doi.org/10.2196/60361 🧪

submitted 15 hours ago • 1 comment

Cohesin and CTCF's chromatin binding becomes more efficient, aiding 3D chromatin architecture in zebrafish embryogenesis. Insights via live imaging! #ZebrafishResearch PMID:39979259, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56889-5 🧪

submitted 16 hours ago • 0 comments

Defining synucleinopathies: #AlphaSynuclein aggregates define diseases like Parkinson's, but diagnosis is clinical & postmortem. New insights aim for better early detection! PMID:39885358, Nat Med 2025, @NatureMedicine @Stanford https://doi.org/10.1038/s41591-024-03469-7 🧪

submitted 17 hours ago • 0 comments

Discover how splice-switching ASOs enhance TRA2β-PE inclusion to lower TRA2β in cancer models. Boost survival across tumors with lncRNA's anti-tumor effects. #CancerResearch PMID:39955311, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56913-8 🧪

submitted 18 hours ago • 0 comments

New #NatureCellBiology: Cells release huge (up to 20µm) vesicles, "blebbisomes," with organelle-rich content. Discover their role in communication! 🧬🧫 #ScienceNews PMID:39984653, Nat Cell Biol 2025, @NatureCellBio https://doi.org/10.1038/s41556-025-01621-0 🧪

submitted 1 day ago • 0 comments

Study reveals phospho-tau S₂₆₂ & S₃₅₆ as key biomarkers of soluble tau assemblies in early-stage Alzheimer's. Potential targets for new treatments! #AlzheimersResearch PMID:39930142, Nat Med 2025, @NatureMedicine https://doi.org/10.1038/s41591-024-03400-0 🧪

submitted 1 day ago • 0 comments

Zenocutuzumab shows promise in phase 2 trial for advanced NRG1 fusion-positive cancers: targets HER2 & HER3 drivers. Results to watch! #CancerResearch PMID:39908431, N Engl J Med 2025, @NEJM https://doi.org/10.1056/NEJMoa2405008 🧪

submitted 1 day ago • 0 comments

5M DNA variants in human genomes show that loss-of-function mutations may disrupt proteostasis, affecting disease outcomes variably. #GeneticsInsights PMID:39753117, Am J Hum Genet 2025, @AJHGNews https://www.cell.com/ajhg/fulltext/S0002-9297(24)00444-0 🧪

submitted 1 day ago • 0 comments

Depression treatments like ketamine & ECT enhance prefrontal cortex plasticity rapidly within days, aiding synapse recovery. #Neuroscience PMID:39558048, Nat Rev Neurosci 2025, @NatRevNeurosci @Cornell https://doi.org/10.1038/s41583-024-00876-0 🧪

submitted 1 day ago • 1 comment

KRAS-driven ADM in PDAC is a key step, with PCD regulators upregulated, priming cells for death. TAK1 involvement confirmed using transgenic models. #PancreaticCancer PMID:39971907, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56493-7 🧪

submitted 1 day ago • 0 comments

Discover a novel CRISPR/Cas9 cytosine base editor using SsdA, a DYW-like deaminase! The G103S mutation boosts C-to-T efficiency & cuts toxicity. Small but mighty #GenomeEditing. PMID:39901278, Genome Biol 2025 @OTSociety https://doi.org/10.1186/s13059-025-03478-w 🧪

submitted 1 day ago • 0 comments

Hippo and MAPK pathway crosstalk leads to resistance against TEAD inhibition with GNE-7883 in cancers via AP-1 upregulation and YAP/TEAD activity. #CancerResearch PMID:39966375, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56634-y 🧪

submitted 1 day ago • 0 comments

Exploring 40+ yrs of research, GHRH goes beyond pituitary roles with diverse biological effects. Fascinating insights! #Endocrinology PMID:39537825, Nat Rev Endocrinol 2025, @NatureRevEndo https://doi.org/10.1038/s41574-024-01052-1 🧪

submitted 1 day ago • 0 comments

Mapping lesion-induced psychosis: 23 cases linked to a brain circuit. Could guide neuromodulation for schizophrenia. #NeuroScience PMID:39937525, JAMA Psychiatry 2025, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2024.4534 🧪

submitted 1 day ago • 0 comments

Biguanide metformin may boost TNBC growth via low-dose AMPK-ACC-FAO signaling activating Src. Potential implications arise! #CancerResearch PMID:39933530, Cell Rep Med 2025 https://www.cell.com/cell-reports-medicine/fulltext/S266637912500014X?rss=yes&utm_source=dlvr.it&utm_medium=twitter 🧪

submitted 1 day ago • 0 comments

Targeted management of CKD is vital for reducing global burden. Advances in risk prediction and data show promise. Join the conversation! #KidneyHealth PMID:39885336, Nat Rev Nephrol 2025, @NatRevNeph https://doi.org/10.1038/s41581-025-00931-8 🧪

submitted 1 day ago • 1 comment

Unveiled: Bacillus subtilis can sense stress #WithoutStressosomes! Discovery shows RsbT's crucial role in stress response, challenging old beliefs. #Microbiology PMID:39939311, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56871-1 🧪

submitted 1 day ago • 0 comments

Explore human organoids! 3D models boosting disease insights, outperforming animals, tackling climate threats & pollutants. Revolutionize health #OrganoidsRevolution PMID:39901045, Nat Med 2025, @NatureMedicine https://doi.org/10.1038/s41591-024-03489-3 🧪

submitted 1 day ago • 0 comments

Intercellular bridges, crucial for meiosis in male mice, prevent transposon activity. TEX14 deficiency causes infertility, revealing critical reproductive roles. #GeneticResearch PMID:39929837, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56742-9 🧪

submitted 1 day ago • 0 comments

Glutathione-deficient Arabidopsis mutants show high glutamate and calcium-based defense signaling. Plants communicate long-distance! 🌿 #PlantDefense PMID:39994230, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-57239-1 🧪

submitted 1 day ago • 1 comment

Discover the 903kb synthetic yeast chromosome synXVI! Built via CRISPR D-BUGS to boost genetic function and mimic wild-type growth. #SyntheticGenome PMID:39833175, Nat Commun 2025, @NatureComms @OTSociety https://doi.org/10.1038/s41467-024-55318-3 🧪

submitted 2 days ago • 0 comments

Unveiling Meibomian gland stem cells! 🧪 Using snRNA-seq, lineage tracing, and imaging in mice, new markers and aging mechanisms exposed. #DryEyeSolution 🔍 PMID:39955307, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56907-6 🧪

submitted 2 days ago • 0 comments

Study compares abelacimab (150mg or 90mg monthly) vs. rivaroxaban (20mg daily) in AF patients at moderate-high stroke risk. Key findings set to reshape AF care! #CardioInnovation PMID:39842011, N Engl J Med 2025, @NEJM https://doi.org/10.1056/NEJMoa2406674 🧪

submitted 2 days ago • 0 comments

Unlocking enzymatic catalysis! This study leverages ML to map reactive conformations of enzyme:substrate complexes, overcoming complex energy landscapes. Major breakthrough for drug discovery! #Bioinformatics PMID:39589882, Proc Natl Acad Sci U S A 2024 https://doi.org/10.1073/pnas.2416621121 🧪

submitted 2 days ago • 0 comments

Up to 70% of cirrhosis patients develop HE, linked to gut microbiota. Study finds a 10x increase in PDC genes, mainly from R. gnavus, in these patients. #LiverHealth PMID:39779925, Nat Med 2025, @NatureMedicine https://doi.org/10.1038/s41591-024-03405-9 🧪

submitted 2 days ago • 0 comments

Pathogen effector HaRxL10 targets Arabidopsis clock gene CHE, disrupting plant development & immunity. Plants vs pathogens: 1 more twist! #PlantImmunity 🌿 PMID:39934132, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56787-w 🧪

submitted 2 days ago • 0 comments

Discover how AHR-ARNT complex senses small molecules for gene programs. Intriguing structure insights power cellular detox & immune response! #StructuralBiology PMID:39900897, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56574-7 🧪

submitted 2 days ago • 0 comments

New paper in Nat Rev Cardiol warns that cannabinoids, despite potential benefits, can cause major heart issues. Balance is key! #CardioCannabis PMID:39849111, Nat Rev Cardiol 2025, @NatRevCardiol @Stanford https://doi.org/10.1038/s41569-025-01121-6 🧪

submitted 2 days ago • 0 comments

Rpl12 acts as a conserved ribophagy receptor across species. Disruption in Rpl12-Atg8 binding results in ribosomal protein and rRNA accumulation. #RibophagyDiscovery PMID:39934334, Nat Cell Biol 2025, @NatureCellBio https://doi.org/10.1038/s41556-024-01598-2 🧪

submitted 2 days ago • 0 comments

New insights into #AorticDissection! GMRSP, encoded by lncRNA H19, reprograms VSMC metabolism. Tests: mice & viral vectors reduce damage. A potential therapy! 🚀🔍 PMID:39966416, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-57011-5 🧪

submitted 2 days ago • 0 comments

Discover: roX RNAs impact not only X-chromosome balance but also autosomal repression in Drosophila. Crucial for male development. 🧬 #Epigenetics PMID:39747148, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-024-55711-y 🧪

submitted 2 days ago • 0 comments

Epigenetic aging speeds up in Huntington's disease, with polycomb repressive complex 1 involved. Analysis in 2 mouse models & 3 disease stages reveals neuronal gene changes. #Huntingtons PMID:39934111, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56722-z 🧪

submitted 2 days ago • 0 comments

Obeldesivir, an oral drug, shows promise for #Marburg virus postexposure protection with up to 90% mortality prevention in nonhuman primates. Let's fight MARV! 🚀 PMID:39805309, Nat Med 2025, @NatureMedicine https://doi.org/10.1038/s41591-025-03496-y 🧪

submitted 2 days ago • 0 comments

Boosting gene therapy! 🎯 Dual AAV vectors hit the jackpot by exploiting host double-strand break repair pathways, doubling delivery size! 🚀🔬 #GeneTherapyRevolution PMID:39934106, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-56738-5 🧪

submitted 2 days ago • 0 comments

What is vip-protection?

submitted 2 days ago • 0 comments

Exploring cancer drug resistance: YAP activation linked with methionine shows resistance. Study shows methionine deprives YAP-TEAD!📉🧬 #CancerResearch PMID:39747898, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-024-55769-8 🧪

submitted 2 days ago • 0 comments