shiva251993.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Unfortunately, I was one of the thousands of new USDA scientists let go yesterday. It was an absolute honor to work there. If anyone in the southeastern Michigan area knows of a role that might match my background, I would really appreciate it. Thank you for your support!

submitted 10 days ago • 61 comments

Strong background in genomics and bioinformatics education and community engagement. Currently located in Bethesda, MD. Updated CV: app.box.com/s/hg5g6z05cz...

submitted 9 days ago • 10 comments

Many universities can not cover the cost of doing research on indirect costs alone, even with negotiated rates >50%. This will result in massive job losses across the country and many smaller programs will cease research activities entirely.

submitted 16 days ago • 2 comments

Apologies for this long post I put together to explain to non-scientists the impact of NIH cuts: Last night, an “atomic bomb” was dropped on the biomedical science community. We were informed that effective immediately, indirect costs on NIH grants (both current and future) would be fixed at 15%.

submitted 16 days ago • 20 comments

"dazzling" "it enlightens and amazes". Fabulous prepublication review of ENDS OF THE EARTH in Publisher's Weekly. 💙📚 #arctic #antarctica #science www.publishersweekly.com/9780593186527

submitted 96 days ago • 5 comments

Copper-controlled gene expression via transmembrane-induced ribosomal stalling https://www.biorxiv.org/content/10.1101/2025.02.05.636593v1

submitted 19 days ago • 0 comments

"... I ended up being reluctant to work with undergraduate researchers at all—until a new student helped me realize what is required to mentor undergraduates, and the rewards it can bring." #NationalMentoringMonth https://scim.ag/3E1bAYj

submitted 30 days ago • 1 comment

www.nature.com/articles/s41...

submitted 52 days ago • 0 comments

The end of an era. @brandontwchen.bsky.social brought us kicking & screaming into cell biology, and what an exciting journey it’s been. We are so very proud of everything he’s accomplished! Join us 1/17 for his defense. Thereafter… watch out NYC, here he comes!!

submitted 52 days ago • 0 comments

The 3 hardest things to learn as a scientist: 1. Trust the data, even when it’s not what you expected, 2. Trust the data, allowing it to change your direction, 3. Trust the data, but not too much: test with new data at every turn.

submitted 56 days ago • 3 comments

Metformin targets mitochondrial complex I to lower blood glucose levels www.science.org/doi/10.1126/...

submitted 65 days ago • 2 comments

I guess it's already a weakness for me! Noted. 😂 www.science.org/content/arti...

submitted 66 days ago • 0 comments

Nutrient-driven histone code determines exhausted CD8+ T cell fates ACLY-deficient CAR T cells targeting the tumor-associated antigen disialogangliosi www.science.org/doi/10.1126/...

submitted 74 days ago • 2 comments

Immunologists, time to embrace your inner neuroscientist 🧠🧪 Macrophages (yes, #macrophages) release glutamate (yes, #glutamate) to sensory neurons engaging in the muscle stretch reflex. Very cool paper! #neuroscience #immunology www.nature.com/articles/s41...

submitted 76 days ago • 2 comments

Although tricky to target, #ProstateCancer cells that lack p53 still depend on the integrated stress response and can be killed with inhibitors of the enzyme GCN2 that disrupt purine synthesis. Read more in #ScienceSignaling: scim.ag/3D6Lyme

submitted 75 days ago • 0 comments

Liver metabolizes high fructose corn syrup to fructose, which leads to increase production of LPC lipids that promote tumor growth. #Glycotime www.nature.com/articles/s41...

submitted 76 days ago • 1 comment

Well this is interesting. No more F32 at NCI. Replaced with K32. Anyone know why?

submitted 76 days ago • 4 comments

Science takes time - a lot of time. Time that is more and more difficult to make available because of increased workloads. Time that exceeds the temporary contracts of postdocs and PhDs. I'll illustrate this using our paper published in Nature yesterday. 🧵 (1/x) www.nature.com/articles/s41...

submitted 89 days ago • 22 comments

Inhibition of microtubule polymerization and dynein impairs the nuclear localization of the ependymoma-associated ZFTA-RELA fusion protein and NF-κB activation https://www.biorxiv.org/content/10.1101/2024.11.26.625308v1

submitted 89 days ago • 0 comments

Opinion piece: Federal #research programs should support the most talented scientists at the nation’s top universities. Caps on the number of applications allowed from a single institution risk undermining that mission: www.pnas.org/doi/10.1073/... #grants #DepartmentOfEnergy #FederalFunding

submitted 89 days ago • 3 comments

super interesting. thank you!

submitted 89 days ago • 0 comments

Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition 🧪 Congrats @richpossemato.bsky.social & team for the very cool work! www.nature.com/articles/s42...

submitted 90 days ago • 0 comments

Mitochondrial Nicotinamide Nucleotide Transhydrogenase: Role in Energy Metabolism, Redox Homeostasis, and Cancer | Antioxidants & Redox Signaling 🧪https://www.liebertpub.com/doi/10.1089/ars.2024.0694

submitted 91 days ago • 1 comment

Evolving cell states and oncogenic drivers during the progression of IDH-mutant gliomas - Nature Cancer 🧪 www.nature.com/articles/s43...

submitted 93 days ago • 0 comments

The science version of “what doesn’t kill me makes me stronger”: Scientists with ‘near misses’ early in their careers outperform those with ‘narrow wins’ in the longer run. www.nature.com/articles/s41...

submitted 92 days ago • 2 comments

Grant agency: "In the end, despite some initial enthusiasm, the panel was not convinced [...], and expected that the impact in the field is likely to be low." Despite evidence to the contrary, funding bodies remain confident they can predict the success of a project. elifesciences.org/articles/13323

submitted 92 days ago • 3 comments

A very interesting and important read for future academics! 😊 www.pnas.org/doi/10.1073/...

submitted 92 days ago • 0 comments

Listen up 👂 It's hard to over-hype this paper from Michelle Monje and Crystal Mackall on cellular therapy for #DIPG, a fatal childhood brain cancer. It's not a perfect therapy; doesn't always work. By goodness, what progress we are making! #CanSky #MEDsky #PedCanSky www.nature.com/articles/s41...

submitted 103 days ago • 0 comments