sjenkinsmd.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

New episode! We talk about REMAP-CAP’s hydrocortisone trial, intensive BP control in diabetes, aldosterone synthase inhibitors for HTN, and reduced dose apixaban for cancer associated thrombosis. podcasts.apple.com/us/podcast/l...

submitted 9 hours ago • 0 comments

20,000 in ruby red Utah on their feet, in community, and ready to organize for a better world. A better world is possible.

submitted 11 days ago • 1643 comments

Patients were randomized to FIT vs colonoscopy for colon cancer screening. Participation in any form of screening was 31.8% in the colonoscopy group and 39.9% in the FIT group. 10-year colon cancer mortality risk was 0.22% in colonoscopy arm and 0.24% in FIT arm. www.thelancet.com/journals/lan...

submitted 26 days ago • 0 comments

Among persons with type 2 diabetes and atherosclerotic cardiovascular disease, chronic kidney disease, or both, oral semaglutide was associated with a significantly lower risk of major adverse cardiovascular events than placebo #MedSky #CardioSky #NephSky www.nejm.org/doi/full/10....

submitted 26 days ago • 0 comments

In this RCT of patients with cancer-associated VTE, reduced dose apixaban was non-inferior to full dose apixaban at preventing recurrent VTE over a median duration of 11.8 months, and had a significant reduction in clinically relevant bleeding. #MedSky #Thrombosis www.nejm.org/doi/full/10....

submitted 26 days ago • 0 comments

The SPRINT trial showed cardiovascular benefits for intensive blood pressure lowering, but did not include patients with diabetes. This new trial of 12,000 patients with type 2 diabetes in China found that targeting BP<120 is better than BP<140 #MedSky #CardioSky www.nejm.org/doi/full/10....

submitted 28 days ago • 0 comments

New episode of our podcast! We tackle low dose DOACs for VTE prevention, biomarkers for antibiotic duration (not great), GPT-4 for physician performance, and a lot more! Check it out! #MedSky podcasts.apple.com/us/podcast/l...

submitted 29 days ago • 0 comments

In patients with spontaneous intracerebral hemorrhage and atrial fibrillation, DOACs vs no AC significantly reduced risk of ischemic stroke (0.83 vs 8.6 per 100 patient years) but increased risk of recurrent hemorrhage (5 vs 0.82 per 100 patient years). #MedSky www.thelancet.com/journals/lan...

submitted 37 days ago • 0 comments

Compared with noninvasive ventilation, high-flow nasal oxygen met prespecified criteria for noninferiority for the outcome of endotracheal intubation or death within 7 days in 4 of the 5 patient groups with acute respiratory failure. #MedSky #PulmCrit #PulmSky jamanetwork.com/journals/jam...

submitted 37 days ago • 0 comments

New clinical practice update from AGA on portal vein thrombosis in cirrhosis #cirrhosis #thrombosis #LiverSky www.gastrojournal.org/article/S001...

submitted 47 days ago • 0 comments

Last night SLFS was showing Life Aquatic with Steve Zissou. One of my all time favorites. #FilmSky

submitted 54 days ago • 0 comments

In this non-inferiority trial of 2800 patients with unprovoked VTE, reduced dose DOAC did not meet non-inferiority criteria, but rates of recurrent VTE were low in both groups, and there was significantly less bleeding in the reduced dose group. #MedSky #Thrombosis www.thelancet.com/journals/lan...

submitted 55 days ago • 0 comments

In this RCT of critical care patients with suspected sepsis, procalcitonin-guided protocol led to shorter duration of antibiotics, with no difference in mortality. There was no difference in antibiotic duration when CRP-guided protocol was used. #MedSky #Sepsis jamanetwork.com/journals/jam...

submitted 55 days ago • 0 comments

Of 46 patients with H5N1, 42 patients (93%) had conjunctivitis, 22 (49%) had fever, and 16 (36%) had respiratory symptoms; 15 (33%) had conjunctivitis only. No hospitalizations and no deaths. There was no human-to-human transmission. #MedSky www.nejm.org/doi/full/10....

submitted 55 days ago • 1 comment

New guidelines for management of acute coronary syndromes from @ahajournals.bsky.social #MedSky #CardioSky www.ahajournals.org/doi/10.1161/...

submitted 55 days ago • 0 comments

RIP to one of the greatest. I loved him in The Conversation too.

submitted 56 days ago • 0 comments

Does gabapentin increase risk of falls in elderly? When compared to incident use of duloxetine, there was no increase in fall-related visits. In fact gabapentin users had a lower hazard of having a fall-related visit. Not an RCT, but an interesting study #MedSky www.acpjournals.org/doi/10.7326/...

submitted 59 days ago • 0 comments

This systematic review "found no moderate- or high-level evidence to support that compliance with or implementation of CMS Severe Sepsis and Septic Shock Management Bundle (SEP-1) was associated with sepsis mortality." www.acpjournals.org/doi/10.7326/...

submitted 59 days ago • 0 comments

In this SMRA, moderate-intensity statin + ezetimibe or treating to target was associated with significantly lower LDL cholesterol levels and reduced risk of new-onset diabetes and intolerance compared to high dose statin. No difference in mortality #MedSky #CardioSky jamanetwork.com/journals/jam...

submitted 59 days ago • 0 comments

In addition to a lower risk of MI, HF, and stroke, "patients who took GLP-1 drugs had a modest reduction in substance use and psychotic disorders, poor mental health outcomes, neurocognitive illnesses like dementia and Alzheimer disease, and seizures." #MedSky www.nature.com/articles/s41...

submitted 59 days ago • 0 comments

Many hospital pulse oximeters routinely read falsely higher in individuals with darker skin color than in those with lighter skin color and are less precise. Fixing this problem will require better regulation and financial incentives. #MedSky jamanetwork.com/journals/jam...

submitted 59 days ago • 0 comments

Inhalers for asthma and COPD contribute a significant amount of carbon to the atmosphere. Manufacturers are developing low-carbon inhalers, and that means new patents and extended monopolies. Inhalers aren't going to get cheaper anytime soon. #MedSky www.nejm.org/doi/full/10....

submitted 59 days ago • 0 comments

In patients with previous MI and clinically significant ventricular tachycardia, early catheter ablation was more effective than anti-arrhythmic therapy (amiodarone or sotalol) alone at reducing ICD shocks and sustained VT. #MedSky #CardioSky www.nejm.org/doi/full/10....

submitted 62 days ago • 1 comment

In patients with post-thrombotic syndrome receiving venous stent recanalization of iliofemoral veins or IVC, there was no difference in stent patency with aspirin + rivaroxaban compared to rivaroxaban alone. #MedSky #Thrombosis www.ahajournals.org/doi/10.1161/...

submitted 62 days ago • 0 comments

In this subgroup analysis of the ARTESiA trial, treatment with apixaban in people with subclinical atrial fibrillation and a history of stroke or transient ischemic attack led to a 7% absolute risk reduction in stroke or systemic embolism over 3.5 years. #MedSky www.thelancet.com/journals/lan...

submitted 62 days ago • 0 comments

This RCT assessed whether GPT-4 improves physician performance on open-ended management reasoning tasks compared to conventional resources. Physicians using the LLM scored significantly higher compared to those using conventional resources. #MedSky www.nature.com/articles/s41...

submitted 62 days ago • 1 comment

We often stop metformin when eGFR < 30 (CKD stage 4). In this observational study of 4,278 patients with type 2 diabetes and CKD stage 4, stopping metformin (40.1% of patients) was associated with lower 3-year survival (63.7% vs 70.5%). Time for an RCT? #MedSky #NephSky www.ajkd.org/article/S027...

submitted 62 days ago • 1 comment