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skleinstein.bsky.social
Computational immunologist; Professor at Yale School of Medicine; Co-Director, Computational Biology & Biomedical Informatics; B cell receptor sequencing analysis, http://immcantation.org + multi-omics signatures of infection, vaccination & autoimmunity.
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Regular Contributor

Next week, we are hosting an international scientific workshop focused on the pathogenesis of #LongCovid at @yalemed.bsky.social. Please join us on May 15th to learn about what we know and what we need to investigate next to get to the root causes to accelerate therapies 👇🏼👇🏼

Don’t forget! 🌺🧪 Our HIPC symposium is happening tomorrow — join us for a great lineup of talks from @bjoernpeters.bsky.social, @lungdrc.bsky.social, @settelab.bsky.social, Victoria Zyulina & Thomas Hagan Tues May 6th | 8:30-10:30 am | Room 313C #Immunology #AAI2025 #HIPC

Come get our #immune data, free #FAIRsharing is at @immportdb.bsky.social - from @columbiauniversity.bsky.social @icahn.bsky.social @yalemedicine.bsky.social @stanfordimmunology.bsky.social @benaroyaresearch.bsky.social @lji.org MIT, Seattle Children's #AAI2025 #ImmuneSky #IDsky

What if LLMs could “read” & “write” biology? 🤔 Introducing C2S‑Scale—a Yale and Google collab: we scaled LLMs (up to 27B!) to analyze & generate single‑cell data 🧬 ➡️ 📝 🔗 Blog: research.google/blog/teachin... 🔗 Preprint: biorxiv.org/content/10.1...

Below, from earlier today, confirmed @statnews.com www.statnews.com/2025/04/18/n...

Exciting news!! We are happy to announce that we will have a HIPC Symposium at @aai.org on Tues, May 6th. HIPC will also have a Super Booth at #AAI2025 along with @iedb.bsky.social and the iAKC Project. Check out the full Symposia list, and see you there! 🔗: immunology2025.aai.org/guest-sympos...

Great to have our latest review "The cellular factors that impair the germinal center in advanced age" out @jimmunol.bsky.social. Work led by @wsfoster.bsky.social and Edith Marcial-Juárez. With @sanmarti92.bsky.social creating the beautiful GC images in figure 2. doi.org/10.1093/jimm...

WHERE WILL YOU BE ON MARCH 7TH!? Head to www.standupforscience2025.org/local-event-information/ or the link in our bio to find your closest event—or add one if you're hosting one! #standupforscience2025

🚨☀️ Hey Bluesky! Know anyone near the following cities that would be willing to help us Stand Up for Science? ☀️🚨 Annapolis, MD Bismarck, ND Boise, ID Charleston, WV Dover, DE Jackson, MS Anchorage or Juneau, AK Montpelier, VT Richmond, VA Send them our way! #standupforscience2025

Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence

Scientists are now organizing events, called Stand Up for Science, on 7 March in Washington, D.C., and state capitals. So far, they have attracted more than 100 volunteers from some 30 states who are hoping to rally support for research as a public good. scim.ag/4328LAD

Presentations from the 2025 Immcantation Users Group Meeting are now available on the Immcantation YouTube channel! Thank you to our speakers and participants! www.youtube.com/playlist?lis... #immcantation #airrseq #immunosky

Our collaborators identify multi-omic factor that predicts #LongCovid Among 50+ authors include @sesmalab.bsky.social @joanndarce.bsky.social @bjoernpeters.bsky.social @slimfourati.bsky.social @droferlevy.bsky.social @leying2024.bsky.social #IDsky #MedSky www.biorxiv.org/content/10.1...

Our collaborators @rgottardo.bsky.social and Ken Stuart (+ others) describe tagtango, an application to compare #single-cell annotations. #bioinformatics academic.oup.com/bioinformati...

Unlocking new insights with nipalsMCIA. This tool speeds up data analysis for big datasets by clustering and visualizing info faster than before. Check it out for both bulk and single cell data on Bioconductor with how-to guides and extras online.

nipalsMCIA: Flexible Multi-Block Dimensionality Reduction in R via Nonlinear Iterative Partial Least Squares https://www.biorxiv.org/content/10.1101/2024.06.07.597819v1

Interested in B cell receptor repertoire analysis? We have a great set of speakers lined up for the “2025 Immcantation Users Group Meeting!” Check out the UPDATED program and register for this free virtual meeting taking place on 1/30/25 10AM-1:40PM (ET) at: immcantation.github.io/users-meetin...

Don’t miss the “2025 Immcantation Users Group Meeting” on 1/30/25 10AM-1:40PM (ET) to learn how AIRR-seq can be used to study infection, vaccination, clonal lineages, and more. **UPDATED PROGRAM** and registration: immcantation.github.io/users-meetin... #immcantation #AIRRseq #immunosky #immunology

Looking forward to hearing from the great speakers lined up for the “2025 Immcantation Users Group Meeting!” Check out the program and register for this free virtual meeting 1/30/25 10AM-1:40PM (ET) at: immcantation.github.io/users-meetin... @immcantation.bsky.social

Find some of our over 50 investigators in Starter Pack. If you are one in our collaboration - please reply OR write a DM to @rgottardo.bsky.social to ask to be added. (Know you need adding - @camilacoelho.bsky.social and @joanndarce.bsky.social ) bsky.app/starter-pack...

Investigators, if your name does not appear on the Starter Pack of HIPC investigators, please send a message to @rgottardo.bsky.social and ask to be added, or write a reply to him. We will be reminding you about this in meetings in the next few weeks. bsky.app/starter-pack...

Immcantation.org user or interested in B cell repertoire analysis? Register now for “2025 Immcantation Users Group Meeting”. FREE virtual meeting 1/30/25 10AM-1:40PM (ET). Info at: immcantation.github.io/users-meetin... #immcantation #AIRRseq #immunosky

Our collaborators designed an #immune health metric, a way of calculating the state of the #system. Study from earlier this year. Authors include @tsanglab.bsky.social @skleinstein.bsky.social #IDSky #MedSky @naturemedicine.bsky.social www.nature.com/articles/s41...

I’ve tried to put together a starter pack of immunologists/scientists exploring B Cell Repertoires and Antibody Affinities. Please feel free to share/join! go.bsky.app/4P64DmM

Thanks @tsanglab.bsky.social for putting this together! #immunology #datascience go.bsky.app/PjH2Fuj

Ok, I tried to create my own list of people working on developing statistical or machine learning models applied to omics data. I am sure I missed a lot of cool people. If you'd like to be added, let me know. #Stats #ML #Omics go.bsky.app/73rcuJn

Save the date! It may be a while to go yet, but I’m very excited for our B-cellapalooza in 2026!

Inspired by @rodrahimi.bsky.social 's noble efforts linking immunologists together over here, let's try and get more specifically TCR/BCR/AIRR/repertoire chat going with this starter park go.bsky.app/Gi2dcGd Drop me a beep to get added or suggest others!

Are you an Immcantation.org user or interested in B cell repertoire analysis? Register now for the 2025 Immcantation Users Group Meeting! The meeting will feature talks from users showcasing how they use Immcantation in their research. Info and registration at: immcantation.github.io/users-meetin...