slefkopoulos.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

🥂Congratulations to Luo & co for their new study in our journal showing that, upon intrahepatic biliary duct damage, gallbladder smooth muscle cells migrate to the common hepatic duct, where they promote #regeneration of the intrahepatic biliary duct. www.nature.com/articles/s41...

submitted 6 days ago • 0 comments

💫NEW: Luo & co show in zebrafish and mouse that, upon intrahepatic biliary duct damage, gallbladder smooth muscle cells migrate to the common hepatic duct, where they promote regeneration of the intrahepatic biliary duct. 👉https://rdcu.be/eacNY www.nature.com/articles/s41...

submitted 8 days ago • 0 comments

🥂Congratulations to @valentatormenta.bsky.social, Perry & co for their new study in @naturecellbiology.bsky.social proposing that maintaining a robust redox ratio is key to clonal prevalence in the skin. www.nature.com/articles/s41...

submitted 9 days ago • 0 comments

👋Our February issue's out! Cover: #glioblastoma 👉🏼Review on #mitochondria #ProteinImport 👉🏻Viewpoint on #LipidMetabolism 🔬 #HumanEmbryos #NuclearSpeckles #PhaseSeparation #autophagy #mitosis #pluripotency #hematopoiesis #LipidDroplets & more! www.nature.com/ncb/volumes/...

submitted 11 days ago • 0 comments

Nature research paper: Engineered heart muscle allografts for heart repair in primates and humans https://go.nature.com/4hdLyzN

submitted 27 days ago • 0 comments

🥂Congrats to @brumbaugh-lab.bsky.social & co for their new study in @naturecellbiology.bsky.social showing that H3K36 methylation maintains #intestinal epithelial fate commitment and is involved in #regeneration. rdcu.be/d8awu www.nature.com/articles/s41...

submitted 25 days ago • 0 comments

For new followers! A pack on professional journal editors in the life sciences. go.bsky.app/Lj5TDXn

submitted 27 days ago • 1 comment

People around us voted for elimination of every tiny portion of their huge pie that we managed (not to earn but) to have a slight chance of claiming; for elimination of our right to existence and decency. Do you expect us to go back to our closets? Well, that’s NOT gonna happen.

submitted 29 days ago • 0 comments

Our new paper defining the role of H3K36 methylation in regulating cell fate and plasticity is available online: rdcu.be/d5AEc Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!

submitted 46 days ago • 1 comment

NEW: Zhang & co identify the transcription factor GABPA as a regulator of #ZygoticGenomeActivation, epiblast formation and naive #pluripotency establishment. www.nature.com/articles/s41...

submitted 46 days ago • 0 comments

🎄Our last issue for 2024 is out! Cover: #CellDivision in #embryos 👉🏿Comment on the 'Women in #Autophagy' initiative 🔬on: #bone #EmbryoDevelopment #senescence #mitochondria #diabetes #PhaseSeparation #metastasis #sequencing & more! www.nature.com/ncb/volumes/...

submitted 69 days ago • 0 comments

💫NEW by Lu, Bartek, Kanu & Swanton & co: analyses of data from the TRACERx cohort of #LungCancer patients delineate how FAT1 regulates homologous recombination repair, chromosomal instability & whole-genome doubling with distinct mechanisms. www.nature.com/articles/s41...

submitted 55 days ago • 0 comments

☕This year Granath-Panelo and Kajimura reviewed evidence of #mitochondria heterogeneity in different contexts and discussed how mitochondrial malleability contributes to cell fate determination and tissue remodeling. 👉https://rdcu.be/d5gHT www.nature.com/articles/s41...

submitted 57 days ago • 0 comments

☕This year, in our #CellDeath focus: Toshitaka Nakamura & Marcus Conrad reviewed the susceptibility of #tumors to #ferroptosis, which could be exploited to treat #cancer. 👉https://rdcu.be/d493Q www.nature.com/articles/s41...

submitted 58 days ago • 0 comments

☕This year, in our #CellDeath focus: Glover, Schreiner, Dewson & Tait reviewed the intersection of #mitochondria and cell death. #pyroptosis #ferroptosis #necroptosis #apoptosis 👉https://rdcu.be/d46gt www.nature.com/articles/s41...

submitted 59 days ago • 1 comment

Happy new year everyone and I 've an exciting announcement to make: @naturecellbiology.bsky.social is now open to considering #preclinical studies & #ClinicalTrials, including #CellTherapy or #genetherapy, among others. Feel free to contact the handling editor for more info (yes, that 'd be me!)

submitted 55 days ago • 0 comments

☕This year, in our #CellDeath focus: Kaiwen W. Chen & Petr Broz reviewed recent work highlighting the regulation of gasdermins and emerging biological roles, including in non-lethal pore formation and host defence. #pyroptosis 👉https://rdcu.be/d4BME www.nature.com/articles/s41...

submitted 64 days ago • 0 comments

Aaaaand finally: #NCB2024 In November, @ralfhadams.bsky.social & co identified a distinct subset of post-arterial #capillaries, termed type R, which contribute to trabecular #bone formation in the diaphysis and respond to anti-#osteoporosis treatments. www.nature.com/articles/s41...

submitted 56 days ago • 0 comments

☕This year, in our #CellDeath focus: Man & Kanneganti reviewed how pattern-recognition sensors in innate #ImmuneCells recognize and respond to cell-death signatures, and highlight molecular targets for potential therapeutic development. 👉https://rdcu.be/d4uDO www.nature.com/articles/s41...

submitted 65 days ago • 0 comments

#NCB2024 In November, Klein & co showed that blocking #CellDivision does not affect differentiation of major cell types during #gastrulation and segmentation. rdcu.be/d5gI8 www.nature.com/articles/s41...

submitted 57 days ago • 0 comments

#NCB2024 In October, Inoue & co showed that JARID2-#PRC2 initiates H3K27me2 deposition during the 8-cell-to-morula transition, following H2AK119 mono-ubiquitylation deposition; and it is required for H3K27me3 deposition at the #blastocyst stage. rdcu.be/d491q www.nature.com/articles/s41...

submitted 58 days ago • 0 comments

#NCB2024 In October, Schuh & co devised a #LiveImaging approach to spatiotemporally dissect mouse #ovulation ex vivo. www.nature.com/articles/s41...

submitted 59 days ago • 0 comments

Average German person speaks English at WHAT level? As a non-German individual living in Germany, I can 100% assure you this is NOT what I ‘ve experienced (far from it). So, either this statement is false or Germans actually can speak English, but don’t wanna do it. There are always exceptions ofc.

submitted 62 days ago • 3 comments

#NCB2024 In October, Zweigerdt, Dardano, Drakhlis & co generated human pluripotent stem cell-derived #cardiac #organoids capable of undergoing endothelial-to-hematopoietic transition and producing #hematopoietic cells. www.nature.com/articles/s41...

submitted 64 days ago • 0 comments

#NCB2024 In October, @toettch.bsky.social, McNamara & co reported that, in #gastruloids, cell sorting rearranges patchy domains of Wnt activity into a single pole, which defines the anterior–posterior axis. rdcu.be/d4vk5 www.nature.com/articles/s41...

submitted 65 days ago • 0 comments

#NCB2024 In September, @maitrejl.bsky.social, Schliffka, Mukherjee & co showed that in the early mouse #embryo inverse blebs grow into cells at cell–cell adhesion sites in response to luminal fluid accumulation and pressure build-up. rdcu.be/d4uCu www.nature.com/articles/s41...

submitted 65 days ago • 0 comments

#NCB2024 In August, @jshendure.bsky.social, Hamazaki & co reported that an early pulse of retinoic acid robustly induces human #gastruloids with a #NeuralTube, segmented #somites and more advanced cell types than conventional gastruloids. www.nature.com/articles/s41...

submitted 66 days ago • 1 comment

#NCB2024 In July, Liang, Yan, Long, Ji et al. found that the origin and dynamics of 5-hydroxymethylcytosine (5hmC) during early development are not conserved between humans and mice and that 5hmC contributes to the activation of human embryonic genes. www.nature.com/articles/s41...

submitted 66 days ago • 0 comments

We've just joined Bluesky 🎉 Follow us for research, news, comment and opinion from Nature journal 🧪

submitted 68 days ago • 36 comments

#NCB2024 In July, @tamraogilvie.bsky.social, Taylor, @olivier-saulnier.bsky.social & co reported a noncanonical role for OTX2 in regulating #AlternativeSplicing and a stem cell and pro-tumorigenic splicing program in group 3 #medulloblastoma. www.nature.com/articles/s41...

submitted 66 days ago • 1 comment

#NCB2024 In July, in 2 independent studies, Sun, Liu et al. and Sun et al. developed SPATAC-seq to map the #chromatin accessibility landscape of zebrafish #embryogenesis and mouse #organogenesis, respectively; they identified transcription regulators that determine cell fate. 👇

submitted 67 days ago • 1 comment

Hi there, my wonderful authors! From today, I will be on annual leave to return on January 8. I will try to attend to matters/questions/submissions as soon as possible upon my return. I hope you can all get some time to relax and thank you for your patience. Happy holidays! 🎄 ⛄️ ❄️

submitted 68 days ago • 0 comments

Every December, Nature puts together a list of the 10 people who helped shape science that year. This year's Nature's 10 list includes: a fraud buster, a nuclear-clock maker and a virus hunter. Find the full list of remarkable figures: www.nature.com/immersive/d4... 🧪

submitted 68 days ago • 2 comments

#NCB2024 In June, Schuh & co analyzed #proteostasis in mammalian #oocytes and ovaries: found that the maintenance of oocytes involves exceptional protein #longevity, and many of the extremely long-lived proteins decline as the ovary ages. www.nature.com/articles/s41...

submitted 68 days ago • 0 comments

Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵

submitted 69 days ago • 21 comments

#NCB2024 In June, Meissner & co reported a lineage-tracing strategy to track #extraembryonic gut #endoderm cells over development; showed these cells are eventually eliminated in a p53-dependent manner and neighboring embryonic cells clear their remnants. www.nature.com/articles/s41...

submitted 69 days ago • 0 comments

#NCB2024 In June, Liu, Xie & co profiled putative cis-regulatory elements in mouse #oocytes and pre-implantation #embryos. They further identified the transcription factors TCF3 and TCF12 as key regulators of #folliculogenesis. rdcu.be/d3NiG www.nature.com/articles/s41...

submitted 71 days ago • 0 comments

#NCB2024 In May, @knoblich-lab.bsky.social & co performed whole-tissue lineage tracing in human #cerebral #organoids to reveal that a subpopulation of symmetrically dividing cells can adjust its lineage size depending on tissue demands. #CellBio2024 www.nature.com/articles/s41...

submitted 71 days ago • 0 comments

Anyone else here identifying as LGBTQIA+ in STEM? Advocating for LGBTQIA+ rights, diversity and inclusion in STEM is one of my main goals as a scientist, editor and non-binary individual. Let’s connect!

submitted 73 days ago • 3 comments

My pick this month: a study by Daley, Jing & co published by Cell Stem Cell and generating CAR iPSC-T cells with enhanced antitumor activity. rdcu.be/d3rH2 www.nature.com/articles/s41...

submitted 74 days ago • 0 comments