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soh.am
I run @popvax.com (https://popvax.com). We develop mRNA vaccines using computational protein design, including a broadly-protective COVID-19 vaccine candidate to preempt new variants that will soon enter Phase I. I used to build robots (https://soh.am).
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It is indeed striking how much AF3-based methods struggle to generalize to novel protein-ligand interfaces. It is also interesting that there remains a meaningful delta between AF3 and other reproductions at the most difficult generalization task (~25% vs ~13% success rate, so roughly double).

submitted 20 days ago • 2 comments

It's long seemed that molecular biology is a natural home for ML interpretability research, given the maturity of human-constructed models of biological mechanisms—permitting direct comparison with their ML-derived counterparts—unlike vision and NLP. Our first foray below👇.

submitted 18 days ago • 0 comments

I'm delighted to announce that PopVax (@popvax.com) has been awarded $2M by the US Biomedical Advanced Research and Development Authority (@bardagov.bsky.social) as a winner of the first stage of BARDA’s Patch Forward Prize for our seasonal influenza vaccine, along with our partner LTS. (1/12)

submitted 18 days ago • 1 comment

Rare bird flu strain #H5N9 found in California flock infected with #H5N1, reports @washingtonpost.com. "Culling flocks is costly," says @jennifernuzzo.bsky.social . "We see that in the price of eggs, and the continued infection of cows will only add to the economic burden." Read more ⤵️

submitted 30 days ago • 0 comments

So here's an interesting development... It's been observed that shingles vaccination with the live attenuated vaccine Zostavax: www.medrxiv.org/content/10.1... and also with the (much more effective) recombinant vaccine: www.nature.com/articles/s41... But, though the study designs are strong...

submitted 52 days ago • 7 comments

I've written a short piece about the potent, broadly-protective flu vaccines we're developing at PopVax to protect against both seasonal influenza strains and potential pandemic influenza such as the H5N1 strains currently circulating in cows chronicles.popvax.com/p/potent-bro... (thread below)

submitted 56 days ago • 1 comment

I'm co-hosting the first Builders in Biology meetup with Samarth Jajoo in Hyderabad on Jan 7 at the @popvax.com lab. It's an informal gathering to discuss research ideas people are excited about. Please feel free to register here if you're interested: lu.ma/po606g0h

submitted 57 days ago • 0 comments

I recently spoke at Ethereum Devcon about PopVax (@popvax.com)'s work developing novel mRNA vaccines to save 1 million lives each year, as part of a series of talks organized by Vitalik Buterin (@vitalik.ca) around his d/acc vision – defensive, differential, and decentralized accelerationism. (1/4)

submitted 68 days ago • 2 comments

Hey folks, I'll be in NYC Sunday & Monday -- would love to catch up with folks working on any subset of vaccines, ML for bio, robotics, and public policy. Feel free to comment here or email me at my_first_name [at] popvax dot com.

submitted 83 days ago • 0 comments

PopVax (@popvax.com) is pleased to announce that NIAID (@niaidnews.bsky.social), part of the US National Institutes of Health, will conduct & sponsor the Phase I clinical trial of PopVax’s next-generation mRNA COVID-19 vaccine as part of the U.S. Government’s Project NextGen. (1/5)

submitted 100 days ago • 1 comment