soundgmh.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Early in life, secondary bile acids are generated by colonizing microbes, associated with risks of immune-mediated diseases and act as immunomodulatory substances. Great collaborative study now online!

submitted 3 days ago • 0 comments

UFMylation of NLRP3 Prevents Its Autophagic Degradation and Facilitates Inflammasome Activation advanced.onlinelibrary.wiley.com/doi/10.1002/...

submitted 2 days ago • 0 comments

Out today in Nature Genetics: Using MS-based proteomics, we mapped 1,200+ plasma proteins in 2,100+ children, showing how genetics & development shape blood protein levels during childhood. nature.com/articles/s41588-025-02089-2 #PediatricProteomics #pQTL First author @liliniu.bsky.social explains ⬇️

submitted 10 days ago • 1 comment

Neutrophil extracellular traps promote the activation of the NLRP3 inflammasome and PBMCs pyroptosis via the ROS-dependent signaling pathway in Kawasaki disease pubmed.ncbi.nlm.nih.gov/39647285/

submitted 6 days ago • 0 comments

Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation h/t Jonathan Kagen www.nature.com/articles/s42...

submitted 6 days ago • 0 comments

A large dataset we hope is helpful for patients who may have CAPS, an #autoinflammatory condition associated with genetic variants in NLRP3. Lots of "variants of uncertain significance" now have a specific readout from our in vitro assay which can help with clinical diagnosis. rdcu.be/d9iRG

submitted 18 days ago • 6 comments

Going into the OR - Time moves so slow in the waiting room.

submitted 17 days ago • 1 comment

How can we clear persistent viruses and cure patients with #LongCOVID - led by @michaelpelusomd.bsky.social, Amy Proal @polybiorf.bsky.social www.sciencedirect.com/science/arti...

submitted 18 days ago • 0 comments

So excited about this new journal. This will become THE journal for human-relevant immunology

submitted 29 days ago • 0 comments

Phenotypic Classification of Multisystem Inflammatory Syndrome in Children Using Latent Class Analysis | MIS-C cases clustered into 3 subgroups with distinct clinical phenotypes, severity, and distribution over time jamanetwork.com/journals/jam...

submitted 31 days ago • 1 comment

There’s so much to learn not only about children’s developing immune systems but also from them. This research underscores how understanding this process could transform our knowledge of human immunology & shape the way we approach treatments for children as they grow and develop. Fantastic work!!

submitted 38 days ago • 0 comments

The identification of a SARS-CoV2 S2 protein derived peptide with super-antigen-like stimulatory properties on T-cells www.nature.com/articles/s42...

submitted 40 days ago • 1 comment

the recording of the 1st int meeting on pediatric #longcovid are FREELY available online (youtube & substack). The 1st meeting where the scientific community clearly talked of LC in kids as a real organic disease needing urgent treatments danilobuonsenso.substack.com/p/presentati... 1/

submitted 48 days ago • 5 comments

With the new year, @bogunoviclab.bsky.social and others uncover new understandings in human genetics and its variability of expression—shaping biological and immunological processes in the human body.

submitted 58 days ago • 0 comments

Diagnostic challenges of long COVID in children: a survey of pediatric health care providers’ preferences and practices @laelyonker.bsky.social www.frontiersin.org/journals/ped...

submitted 60 days ago • 1 comment

wisdom comes in many shapes and sizes. I’ve learned a lot from a lot of different people. I continue to learn the most from you, my son.

submitted 64 days ago • 0 comments

A study from Richmond, CA, reveals BAL-0028, a new inhibitor targeting human NLRP3 inflammasomes, shows promise for inflammatory diseases and resistant mutations, with a unique mechanism unlike current treatments. www.biorxiv.org/content/10.1...

submitted 67 days ago • 0 comments

The N-degron pathway mediates the autophagic degradation of cytosolic mitochondrial DNA during sterile innate immune responses www.cell.com/cell-reports...

submitted 65 days ago • 1 comment

Happy Holidays from our family to yours! May this season bring warmth, joy, and countless moments to cherish with the ones you love. Wishing you all the best as we step into the new year!

submitted 66 days ago • 0 comments

Platelet–Monocyte Aggregate Instigates Inflammation and Vasculopathy in Kawasaki Disease onlinelibrary.wiley.com/doi/full/10....

submitted 67 days ago • 0 comments

#JanuaryIssue | Emerging concepts and treatments in autoinflammatory interferonopathies and monogenic systemic lupus erythematosus Goldbach-Mansky and colleagues propose a pathogenesis-based classification of #autoinflammatory interferonopathies in this #Review bit.ly/4gLCpOx

submitted 71 days ago • 0 comments

Open Access UCL Research: Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency discovery.ucl.ac.uk/id/eprint/10...

submitted 71 days ago • 0 comments

Long−term health outcome and quality of life in children with multisystem inflammatory syndrome: findings from multidisciplinary follow−up at an Italian tertiary−care paediatric hospital link.springer.com/article/10.1...

submitted 67 days ago • 1 comment

Fourteenth International Kawasaki Disease Symposium: Learning From the Past, Looking to the Future - www.cjcpc.ca/article/S277...

submitted 67 days ago • 1 comment

Pediatric SARS-CoV-2 long term outcomes study: cross sectional analysis at baseline US study (654 kids) found that those w COVID had worse scores in fatigue, pain, mobility, & sleep disturbances v uninfected Highlights the need for long-term pediatric studies www.nature.com/articles/s41...

submitted 72 days ago • 0 comments

Another piece to the puzzle of IEI linked to the development of multisystem inflammatory syndrome in children link.springer.com/article/10.1...

submitted 72 days ago • 1 comment

The Central Role of Interleukin-1 Signalling in the Pathogenesis of Kawasaki Disease Vasculitis: Path to Translation Great review from @marditimd.bsky.social onlinecjc.ca/article/S082...

submitted 72 days ago • 0 comments

Single-cell RNA sequencing uncovers molecular mechanisms of intravenous immunoglobulin plus methylprednisolone in Kawasaki disease: attenuated monocyte-driven inflammation and improved NK cell cytotoxicity www.frontiersin.org/journals/imm...

submitted 72 days ago • 0 comments

Exploring the Role of Neutrophil Extracellular Traps in Systemic Lupus Erythematosus www.the-rheumatologist.org/article/expl...

submitted 72 days ago • 0 comments