surojitsural.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Today in #journalclub, we looked at this fantastic new method from the @doudna-lab.bsky.social in Nature Biotechnology! They show how CRISPR–Csm enables single-molecule live-cell imaging of endogenous RNAs. Super cool! www.nature.com/articles/s41...

submitted 6 days ago • 0 comments

AFD Thermosensory Neurons Mediate Tactile-Dependent Locomotion Modulation in C. elegans https://www.biorxiv.org/content/10.1101/2025.02.19.639001v1

submitted 3 days ago • 0 comments

Sources of behavioral variability in C. elegans: Sex differences, individuality, and internal states www.sciencedirect.com/science/arti...

submitted 3 days ago • 0 comments

The neuron-intrinsic membrane skeleton is required for motor neuron integrity throughout lifespan https://www.biorxiv.org/content/10.1101/2025.02.23.639536v1

submitted 3 days ago • 0 comments

PREPRINT OUT ✨ "hack" your microscope to work as a 3D printer! print micrometer sized features at cm scale. a method for easy and cheap microfabrication, with a focus on biological applications. THREAD ↓ www.biorxiv.org/content/10.1...

submitted 4 days ago • 9 comments

DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistance https://www.biorxiv.org/content/10.1101/2025.02.17.638677v1

submitted 6 days ago • 0 comments

Nominations for the 2025 John Maddox Prize are now open. The prize recognises researchers who stand up and speak out for science and evidence-based policy, advancing public discussion around difficult topics, despite challenges or hostility. https://go.nature.com/4194lp6

submitted 5 days ago • 2 comments

Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties 🔘 Form with functional mitochondria. 🔘 Are distinct from large oncosomes. 🔘 Contain multiple organelles. 🔘 Secrete exosomes and microvesicles. www.nature.com/articles/s41...

submitted 6 days ago • 0 comments

This is an excellent article and a must-read ⏬. It also made me curious—have there been past examples of scientists/institutions from well-funded countries actively building such global networks in response to funding crises elsewhere?

submitted 6 days ago • 2 comments

www.theguardian.com/us-news/2025...

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Nervous system–wide analysis of all C. elegans cadherins reveals neuron-specific functions across multiple anatomical scales www.science.org/doi/10.1126/...

submitted 6 days ago • 0 comments

The forkhead transcription factor FKH-7/FOXP acts in chemosensory neurons to regulate developmental decision-making https://www.biorxiv.org/content/10.1101/2025.02.17.638733v1

submitted 6 days ago • 0 comments

Peroxisomal Dysfunction Drives Loss of Dynamic Nutrient Responses to Initiate Metabolic Inflexibility During Aging https://www.biorxiv.org/content/10.1101/2025.02.14.638340v1

submitted 11 days ago • 0 comments

In vivo pulse-chase in C. elegans reveals intestinal histone turnover changes upon starvation https://www.biorxiv.org/content/10.1101/2025.02.13.638128v1

submitted 11 days ago • 0 comments

Happy to share our latest work led by grad student Priyanka Das. Using a genome-wide bacterial screen, we identify that dietary iron limitation extends C. elegans lifespan via its oxidative stress response pathways. www.biorxiv.org/content/10.1...

submitted 11 days ago • 1 comment

Our cross-journal call for paperss on targeted protein degradation is still open for submissions! We welcome submissions focusing on the design, development, and application of targeted protein degradation modalities. @commschem.bsky.social @naturecomms.bsky.social www.nature.com/collections/...

submitted 14 days ago • 0 comments

A dendritic guidance receptor functions in both ligand dependent and independent modes https://www.biorxiv.org/content/10.1101/2025.02.11.637350v1

submitted 15 days ago • 0 comments

Context-specific interaction of the lipid regulator DIP-2 with phospholipid synthesis in axon regeneration and maintenance. https://www.biorxiv.org/content/10.1101/2025.02.06.636954v1

submitted 19 days ago • 0 comments

Discovery of the specialized brain cells that convey and regulate satiety The cells integrate input of food (visual, smell, texture) and gut hormone circuitry. Another jump forward through spatial omics. @cellcellpress.bsky.social www.cell.com/cell/fulltex...

submitted 22 days ago • 4 comments

Check out our latest paper from Cory Pender...A pathogen producing a toxic gas is detected by its possible host and alarm signal is generated to protect the host and its next generation! Much thanks to our Nick Burton and his lab!! Read more here: pubmed.ncbi.nlm.nih.gov/39721586/

submitted 55 days ago • 0 comments

Pathogen-derived cyanide in the environment is detected and detoxified by C. elegans parents, generating a byproduct that acts as an intergenerational signal to protect progeny from infection @cellcellpress.bsky.social @dillinlab.bsky.social www.cell.com/cell/fulltex...

submitted 63 days ago • 0 comments

Loss of an uncharacterized mitochondrial methionine tRNA-synthetase induces mitochondrial unfolded protein response in Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.02.03.636310v1

submitted 22 days ago • 0 comments

A genetic barcoding system lets scientists tag and track cells, making it easier than ever to map gene expression (#transcriptomics) and decode behaviour. https://buff.ly/4hGreqD

submitted 24 days ago • 1 comment

Dafadine Does Not Promote Dauer Development in Pristionchus pacificus www.micropublication.org/journals/bio...

submitted 24 days ago • 0 comments

Dopamine signaling drives skin invasion by human-infective nematodes https://www.biorxiv.org/content/10.1101/2025.01.29.635547v1

submitted 28 days ago • 0 comments

Dr. Qili Liu is the inaugural award recipient of The Hugo Bellen and Catherine Tasnier Drosophila Neurogenetics Lecture. The award recognizes early career scientists and faculty in a key space of Drosophila research—genetics as applied to neuroscience in Drosophila genestogenomes.org/hugo-bellen-...

submitted 27 days ago • 0 comments

In less than a day, over 30 mentors joined the C. elegans Mentor Match Program! Mentors can sign up here: tinyurl.com/37msvdm7 We will start signing up mentees and peer-mentors soon. And please spread the word! You can share this QR code with your lab and encourage them to sign up as mentors.

submitted 28 days ago • 0 comments

Our newest preprint is out: an automated code-free method developed for quantifying synapses in C. elegans (but also useful for other fluorescent puncta/organisms!) that we're calling "WormSNAP" www.biorxiv.org/content/10.1... #wormfeed #neuropapers

submitted 29 days ago • 1 comment

Integrating bulk and single cell RNA-seq refines transcriptomic profiles of individual C. elegans neurons https://www.biorxiv.org/content/10.1101/2025.01.26.634951v1

submitted 31 days ago • 0 comments

Optimising Age-Specific Insulin Signalling to Slow Down Reproductive Ageing Increases Fitness in Different Nutritional Environments onlinelibrary.wiley.com/doi/10.1111/...

submitted 31 days ago • 0 comments

Besides host defense, the immune system contributes to homeostasis within and between tissues regulating blood glucose levels in mice. Fasting, innate ILC2 lymphoid cells proliferated increasing glucagon in the pancreas, and improved gut glucose sensing. #Medsky www.science.org/doi/10.1126/...

submitted 42 days ago • 0 comments

A single-chain antibody-based AID2 system for conditional degradation of GFP-tagged and untagged proteins https://www.biorxiv.org/content/10.1101/2025.01.21.633519v1

submitted 34 days ago • 0 comments

Inhibition of cytosolic translation mitigates mitochondrial dysfunction in C. elegans https://www.biorxiv.org/content/10.1101/2025.01.22.634344v1

submitted 35 days ago • 0 comments

Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing www.sciencedirect.com/science/arti...

submitted 34 days ago • 0 comments

Ergothioneine improves healthspan of aged animals by enhancing cGPDH activity through CSE-dependent persulfidation: Cell Metabolism www.cell.com/cell-metabol...

submitted 35 days ago • 0 comments

Our paper on WormID is out. Moral: building a multi-lab data corpus boosts generalization and performance of ML labeling algorithms. We extended the Neurodata Without Borders format to support this. Resource at wormid.org. www.focolab.org/post/our-pap...

submitted 37 days ago • 0 comments

Functionally diversified BiP orthologs control body growth, reproduction, stress resistance, aging, and ER-Phagy in Caenorhabditis elegans. https://www.biorxiv.org/content/10.1101/2025.01.14.633073v1

submitted 39 days ago • 0 comments

Alternative splicing controls pan-neuronal homeobox gene expression genesdev.cshlp.org/content/earl...

submitted 41 days ago • 0 comments

After a long wait, our paper is out! We show that differences in learning between the sexes are modulated by the NPY receptor, which gates sensory perception. Great work by PhD student, soon to be Dr, Sonu Kurien www.nature.com/articles/s41...

submitted 41 days ago • 7 comments

Development of a size separation technique to isolate Caenorhabditis elegans embryos using mesh filters https://www.biorxiv.org/content/10.1101/2025.01.14.632944v1

submitted 41 days ago • 0 comments

We're returning to TReND-CaMinA! Students and early career researchers across Africa can now apply to join us on July 7-23 at the University of Zambia for an intensive, entry-level course on the basics of comp neuroscience and machine learning. More info: alleninstitute.org/events/trend... 🧠📈

submitted 42 days ago • 0 comments

The old worm people at NYAWM!!! @cswormlab.bsky.social

submitted 43 days ago • 2 comments

Abstract submission and registration for #Worm25 are OPEN! 🪱📣 Don't miss the premier event for Worm researchers this Summer! Submit an abstract on a variety of topics including cell biology, development, gene regulation & genomics, and more: buff.ly/40arx5W 1/2🧵

submitted 43 days ago • 1 comment

by now you probably know that #giantviruses have #histones, but some also have histone variants! Check out our latest preprint on an essential H2B-H2A histone variant in Melbournevirus - a fantastic collaboration with the Abergel Lab, spearheaded by Ale Villalta. www.biorxiv.org/content/10.1...

submitted 42 days ago • 0 comments

Modulation by NPY/NPF-like receptor underlies experience-dependent, sexually dimorphic learning www.nature.com/articles/s41...

submitted 42 days ago • 0 comments

Genomes of the entomopathogenic nematode Steinernema hermaphroditum and its associated bacteria https://www.biorxiv.org/content/10.1101/2025.01.09.632278v1

submitted 47 days ago • 0 comments

As a female academic in her 40s, I think it is extremely important to pay attention to ways in which you get worn down by the constant mini-struggles. As you age, it accumulates and you get to a point where you just can't anymore. This is not just about the extra mentoring or household labor.

submitted 46 days ago • 5 comments