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tomfialab.bsky.social
Senior Scientist and Branco Weiss Fellow at @ethzurich.bsky.social Incoming Assistant Professor at Masaryk University, Brno, Czechia Alumnus of @columbiauniversity.bsky.social, NY Chemical Biology and Supramolecular Chemistry
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Selectively assembling collagen heterotrimers is a challenge. But not for us! Aminopropline-aspartate salt bridges drive the assembly of a hyperstable, a minimal-length, and a special blunt-ended collagen heterotrimer. Now out in @angewandtechemie.bsky.social! onlinelibrary.wiley.com/doi/10.1002/...

submitted 2 days ago • 0 comments

TWeeP (This Week's Paper): A very nice review on the role of water in collagen structure and folding has been published in Biomacromolecules by Giubertoni and coworkers. Check it out! pubs.acs.org/doi/full/10....

submitted 27 days ago • 0 comments

TWeeP (This Week's Paper): In Biomacromolecules, Mukherjee et al. present a neat way of stabilizing collagen triple helices and inducing their fibrillation via terminal aromatic capping groups. (Plus check out the fun TOC graphic!!) pubs.acs.org/doi/abs/10.1...

submitted 42 days ago • 0 comments

Oslo-based Tribune Therapeutics has raised $40 million to advance its way of inhibiting the formation of scar tissue in disease. cen.acs.org/pharmaceutic... #chemsky🧪 #biosky

submitted 45 days ago • 0 comments

TWeeP (This Week's Paper): Protecting groups for proteins? The Barnardes lab brilliantly uses a "lock"-PNA as a protein PG and the complementary "key"-PNA for deprotection via proximity-driven trans-thioesterification. Now out in @angewandtechemie.bsky.social. onlinelibrary.wiley.com/doi/10.1002/...

submitted 56 days ago • 0 comments

TWeeP (This Week's Paper): Congratulations to my colleague Bartosz and Zibi on the nice work on glucose-derived bis-crownether receptors for photo-controlled binding of amino acid esters in water via isomerization of azobenzenes. Now out in @commschem.bsky.social. www.nature.com/articles/s42...

submitted 77 days ago • 0 comments

Voltage sensitive dyes are great tools for visualizing neuronal firing. Want to learn more about these sensors and how to target them to specific neurons in the brain? Read our Perspective (with Dali Sames and Dave Sulzer), now out in @pubs.acs.org ACS Chem. Neurosci. pubs.acs.org/doi/10.1021/...

submitted 87 days ago • 0 comments

TWeeP (This Week's Paper): Proline is a unique amino acid due to the thermodynamics and kinetics of the Xaa-Pro amide bond. In @pubs.acs.org JACS, @frederiktheisen.bsky.social et al. map out the role of cis-Pro in an intrinsically disordered region of the 14-3-3 protein. pubs.acs.org/doi/10.1021/...

submitted 91 days ago • 0 comments

TWeeP (This Week's Paper): In @pubs.acs.org J. Am. Chem. Soc., Zuo et al. disclosed an innovative two-step tyrosine labeling–IEDDA reaction cascade: Tyrosine Triazine Ligation (YTL). PoC application in synthesis of a library of peptide-based dual-mode imaging probes. pubs.acs.org/doi/abs/10.1...

submitted 98 days ago • 0 comments

TWeeP (This Week's Paper): Is Europe Running out of Chemistry Teachers? ...a nice commentary by Vanessa Zainzinger from @cenmag.bsky.social in @pubs.acs.org ACS Central Science. pubs.acs.org/doi/10.1021/...

submitted 104 days ago • 0 comments

TWeeP (This Week's Paper): Selective protein cleavage under physiological conditions with a synthetic probe and no enzymes involved... sci-fi? No! Now a reality thanks to the cysteine formylation technology by Ojida, Hamachi and coworkers in JACS. pubs.acs.org/doi/10.1021/...

submitted 114 days ago • 0 comments

TWeeP (This Week's Paper): In @angewandtechemie.bsky.social Rai et al. disclosed a tripeptide with an N-terminal azide and C-alkyne that can undergo topochemical polymerization in its crystalline form. The material is good at gluing together biological matter. onlinelibrary.wiley.com/doi/epdf/10....

submitted 119 days ago • 0 comments

TWeeP (This Week's Paper): Happy new year! I'm back with my weekly highlights after the holiday break. Let's kick off 2025 with some nice bioconjugation work by Esteve, Koniev, Lehn et al. in #JACS. Dynamic imine formation triggers proximity-driven SNAr on proteins. pubs.acs.org/doi/abs/10.1...

submitted 126 days ago • 0 comments

TWeeP (This Week's Paper): Challenging peptide sequence? Fear no more! SynTag from @ninahartrampf.bsky.social and coworkers is here to save the day! Read now, in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/...

submitted 154 days ago • 0 comments