topherhuebel.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Measles are contagious. Measles cause 1 in 4 people to be hospitalized. Measles can be deadly especially in children. Measles can cause blindness & deafness. Measles can cause brain damage yrs later. Measles can cause "immune amnesia". Measles are preventable with MMR vaccine. #medsky #IDsky 🛟 😷🧪

submitted 5 days ago • 26 comments

A four-year-old paper claiming conversion therapy reduced same-sex thoughts in gay men has been retracted after criticism from other researchers prompted further review of the work.

submitted 5 days ago • 0 comments

The likelihood to recall a dream in the morning and the ability to remember its content are modulated by a combination of stable individual traits and dynamic night-by-night and seasonal change, according to a study in Communications Psychology. https://go.nature.com/3EKJaCd 🧪

submitted 5 days ago • 1 comment

My lab has a position for a programmer--if you have programming skills and have recently left the NIH please contact me.

submitted 8 days ago • 1 comment

“ERC succeeds because it’s different. Its simple, tailored procedures allow Europe’s best researchers to thrive. Bureaucratic processes designed for other programmes should not be imposed on it.” @marialep.bsky.social spoke up for an independent ERC with a doubled budget today @europarl.europa.eu

submitted 8 days ago • 3 comments

Inter individual variability in the child and adolescent proteome is influenced by genetic variants, age, sex and body mass index @naturegenet.bsky.social #proteomics #genetics www.nature.com/articles/s41...

submitted 8 days ago • 0 comments

Using national registry data from Denmark, 30 maternal diagnoses linked to offspring autism were identified with most associations attributable to family-level factors rather than direct causal effects of maternal diagnoses, according to a paper in Nature Medicine. 🧪

submitted 19 days ago • 1 comment

I want to read you an email that I was asked to keep confidential because I think it explains some of my worries about academia. www.youtube.com/watch?v=shFU...

submitted 12 days ago • 26 comments

GWAS sample sizes are officially in the 7-digit realm🧬 New GWAS for eGFR in 2.2 million (!) individuals @science.org 👉1,026 genomic loci 👉8,901 putative causal variants in 1,818 credible sets in fine-mapping 👉convergence across 1,060 genes in multi-omic integration

submitted 19 days ago • 1 comment

What brain regions are involved in causing psychotic symptoms? Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients! 1/n🧵

submitted 15 days ago • 4 comments

Our paper on Efficient regression for population-scale genome sequencing studies is published and online 1.5 minutes on a single machine academic.oup.com/bioinformati...

submitted 14 days ago • 1 comment

This is another way how you can avoid overlapping axis labels in #tidyplots 🧐 Just swap x-axis and y-axis 🚀 #rstats #dataviz #phd

submitted 14 days ago • 2 comments

Don’t write for the critics. Or the haters. Write because you just remembered the deadline you agreed to 11 months ago.

submitted 22 days ago • 5 comments

Write every day for 1 hour. If you miss a writing day add 1 hour to the next. It’s incredible! Tomorrow I’m writing for 7 years.

submitted 19 days ago • 104 comments

Two moods while writing: 1) this is actually pretty good 2)

submitted 18 days ago • 3 comments

In response to the emergence of H5N1 influenza A viruses as a novel pathogen of cattle, a study in Nature Communications shows that pasteurisation of cows’ milk should effectively inactivate the virus, but that it remains infectious in unpasteurised milk. https://go.nature.com/3WRQ8fb 🧪

submitted 18 days ago • 6 comments

Mitochondria may hold the key to curing diabetes "Researchers at the University of Michigan used mice to show that dysfunctional mitochondria trigger a response that affects the maturation and function of β-cells." www.science.org/doi/10.1126/...

submitted 18 days ago • 3 comments

Here's our latest work on proteome profiling of self-sampled dried blood spots to gain insights into the heterogeneity of the immune response against infections and vaccinations. We enrolled random citizens by postal mail to learn more about the molecular effects beyond those seeking medical care.

submitted 43 days ago • 1 comment

🧵 Why are workflow languages like Snakemake essential for bioinformatics? Let’s explore their power in streamlining genomic data analysis.

submitted 19 days ago • 1 comment

Principal Component Analysis (PCA) before Linear Regression can greatly enhance your data analysis process. I've developed an in-depth course on PCA theory and its application in R programming. Further details: https://statisticsglobe.com/online-course-pca-theory-application-r #pythontraining#d…

submitted 28 days ago • 0 comments

Avoiding text overlap in plots is essential for clarity, and R offers a great solution with the ggplot2 and ggrepel packages. Video: https://www.youtube.com/watch?v=5lu4h_CPhi0 Website: https://statisticsglobe.com/avoid-overlap-text-labels-ggplot2-plot-r More: https://statisticsglobe.com/online-c…

submitted 24 days ago • 0 comments

Remember when the US federal government wrote things like: "One of the justifiable criticisms of human genetic studies is the underrepresentation of participants from diverse populations" It's from the MVP GWAS I keep mining, recently added to the gwas catalog www.science.org/doi/10.1126/...

submitted 19 days ago • 1 comment

Peter Gleick @petergleick I'll be giving a zoom seminar at the University of Arizona: the WRRC Water Webinar: The Three Ages of Water: Prehistoric Past, Imperiled Present, and a Hope for the Future Date: Tuesday, March 4, 2025 Time: 12:00 pm – 1:15 pm Arizona Time Register here:

submitted 21 days ago • 2 comments

Just re-upping this given the news about the measles outbreak in unvaccinated Texas.

submitted 19 days ago • 1 comment

A 𝗻𝗲𝘂𝗿𝗮𝗹 𝗰𝗿𝗲𝘀𝘁 is a group of ectodermal cells that are pinched off during neural tube closure. The neural crest migrates to various locations to contribute to diverse tissues, including melanocytes, craniofacial bones, and peripheral-nerve ganglia. #MedSky #ScienceSky

submitted 19 days ago • 1 comment

The 'PRISMA2020' R package can used to make both static and interactive 'PRISMA' Flow Diagrams. Thanks to @heeminkang.bsky.social for the tip! cran.r-project.org/web/packages...

submitted 22 days ago • 0 comments

Can human genetic evidence can improve drug development success? The latest @hggadvances.bsky.social article by @brent-richards.bsky.social & co. uses IntAct, a protein interaction database, to explore this question: www.cell.com/hgg-advances... #ASHG #HumanGenetics #GeneticsDiscoveries

submitted 27 days ago • 1 comment

It’s a privilege to announce Solve-RD’s latest manuscript based on years of work: “Genomic reanalysis of a pan-European rare-disease resource yields new diagnoses” www.nature.com/articles/s41... A thread (1/n)

submitted 41 days ago • 1 comment

Peer review is fundamental to science and reviewers should be paid, as our new open access and open peer review Journal of the Academy of Public Health does. If you agree, check it out and sign up to review! publichealth.realclearjournals.org

submitted 22 days ago • 1 comment

Out now in Psychol Med 🍪 We show that depression-related changes in food wanting and liking are associated with the macronutrient content of the food. #neuroskyence 🩺 Work w/ @corcerebrum.bsky.social www.cambridge.org/core/journal...

submitted 22 days ago • 0 comments

I am excited to share our latest paper @Nature where we construct a hi-res spatial map of the human hypothalamus, the brain region central in appetite control. It is a collaboration between @IMS_MRL @Cambridge_Uni & @MPI_Metabolism www.nature.com/articles/s41...

submitted 22 days ago • 5 comments

Taking non-invasive glucose tracking to the next level, using Raman spectroscopy, without any needles www.nature.com/articles/s42...

submitted 22 days ago • 11 comments

Eating disorders can take over your whole identity and make you feel like it’s all you are. I had anorexia on and off since I was 12, so I had very little concept of who I was outside of being ‘sick’, ‘in treatment’, ‘tiny’, and ‘disciplined’. Here’s how I found myself again: 🧵

submitted 22 days ago • 2 comments

How the PICAR framework Can Benefit Guideline Systematic Reviews: A Call for Greater Attention (Letter commenting on: J Clin Epidemiol. 2019; 108:64-76) - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

submitted 22 days ago • 0 comments

Curious about muscle metabolism? 🚴‍♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue

submitted 52 days ago • 2 comments

🧠 Daily Feed of Brain Damage 🧠 Cøvid isn't your best friend www.nejm.org/doi/full/10....

submitted 23 days ago • 4 comments

AlphaFold (the archetype): genAI to predict 3D protein structure from amino acid sequence New ChromoGen: genAI to predict 3D genome structure from DNA sequence www.science.org/doi/10.1126/...

submitted 26 days ago • 4 comments

Main outcomes of 29 psychotherapy university outpatient clinics in Germany (N=6624). After therapy, 55% recovered and 8% deteriorated when looking at Brief Symptom Inventory (BSI) scores. Recovery was less frequent in Borderline PD (39%) and more frequent (68%) in specific phobias.

submitted 23 days ago • 2 comments

Evidence has shown that gentle initiation of communication about weight loss supported more positive and well-received conversations. JAMA Insights author @charlottealbury.bsky.social shares techniques that can support effective conversations about weight loss. ja.ma/4gi1yzr #MedSky

submitted 23 days ago • 0 comments

petition.parliament.uk/petitions/70...

submitted 24 days ago • 0 comments

I am excited to share a new paper that is out in PDTRT. We developed an Antagonism scale for the MMPI-3. As @jdmiller.bsky.social and @drlynam.bsky.social remind us, antagonism is an under-appreciated but important construct. We can now measure it via the MMPI-3. psycnet.apa.org/fulltext/202...

submitted 25 days ago • 2 comments

In a global first, Uganda’s Ministry of Health, the World Health Organization (WHO) and other partners today launched a first-ever vaccine trial for Ebola from the Sudan species of the virus, and at an unprecedented speed for a randomized vaccine trial in an emergency.🧵

submitted 24 days ago • 171 comments

Handedness and brain asymmetry have always fascinated neuroscientists and neurologists🫲🫱 With a heritability of ~25%, GWASs have provided key insights into the biology of handedness highlighting the role of microtubules🧬 A nice review on handedness genetics

submitted 23 days ago • 2 comments

American health workers looking to relocate? Doorway to practice medicine in Canada 🇨🇦 We have job openings nationwide. www.canada.ca/en/immigrati...

submitted 24 days ago • 139 comments

This JAMA Insights explores effective communication strategies for clinicians who do not specialize in treating obesity in how to introduce conversations about weight loss with their patients and offer them support and treatment. ja.ma/3EodTF4 #MedSky #MedEd

submitted 24 days ago • 1 comment

Having stupidly agreed to give a talk on polygenic scores - which I know nothing about - have read a stack of PGS papers. As a participant in UK biobank it's annoying to see us described as "patients" in many papers. A pet peeve: except in rare cases study participants are NOT primarily "patients"

submitted 29 days ago • 1 comment

Welcome immigrants from X interested in science to the friendlier skies of @bsky.app, as documented by a new @nature.com survey (but you already knew that 😉) "Bluesky is much better for science. There is much less toxicity, misinformation, and distractions." www.nature.com/articles/d41...

submitted 34 days ago • 252 comments