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worthamlab.bsky.social
Assistant Professor at the Barbara Davis Center for Diabetes at University of Colorado Anschutz Medical Campus. The Wortham lab studies how nutrients govern adaptive and maladaptive responses by pancreatic beta cells in health and metabolic disease.
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Functional #insulin secretory defects occur in the remaining mass of beta cells during human #T1D pathogenesis not strictly correlated with the extent of insulitis #islets www.biorxiv.org/content/10.1...

submitted 7 days ago • 0 comments

Abstracts for #METPHYS2025 are due this Friday! There are multiple short talks available! FEB28 is also the deadline for the Vanderbilt Vibrant program This initiative will provide several awards of $2000 to help new investigators attend www.sablesys.com/metphys2025-...

submitted 8 days ago • 0 comments

We link molecular and functional phenotypes of islet cells from donors with type 1 diabetes to understand impaired insulin and glucagon secretion. Immune signalling, nuclear exclusion, mTOR and lysosomes in alpha cell dysfunction. https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1

submitted 11 days ago • 1 comment

Excited to share our publication in @cp-iscience.bsky.social Islet single-cell transcriptomic profiling during obesity-induced beta cell expansion in female mice #IMM @uthealthhouston.bsky.social @bcmhouston.bsky.social 🧵 www.cell.com/iscience/ful...

submitted 12 days ago • 3 comments

Cutting NIH funds hurts all Americans. Why? Three main reasons: #1: These funds support a huge industry in all states. For every $1 of NIH funding generated, there is a short-term return of ~$2.46 in economic activity. $4B in cuts will take away $10B from the economy.

submitted 23 days ago • 1 comment

Looking forward to discussing this technique for single cell spatially resolved metabolic tracing in BDC journal club today at 10AM MT—don’t miss it! www.nature.com/articles/s42...

submitted 47 days ago • 0 comments

Looking forward to journal club tomorrow where we will discuss this fantastic paper from Zong Wei's lab describing how diet-induced obesity impacts enhancer-associated histone modifications in islets www.nature.com/articles/s41...

submitted 76 days ago • 0 comments

Cool paper, congrats! Beta cells do not tolerate intermittent fasting (24h every third day) during adolescence, which contrasts with beneficial effects in old mice. Might there be a very high sensitivity of beta cells to altered feeding rhythms during a late stage of functional maturation?

submitted 82 days ago • 0 comments

What a pleasant surprise for our recent paper by Dr. Jessica Huang to feature in the 'Year in Review' issue of Nature Reviews Endocrinology - courtesy of Prof. Carmela Evans-Molina. ;-) doi.org/10.1038/s415...

submitted 89 days ago • 0 comments

A comprehensive and much-needed assessment of donor/islet features (and potential confounders) associated with hormone secretion by isolated human islets. Delta cell abundance is anti-correlated with several aspects of beta cell function and seemingly influenced by T2D genetic risk score (!)

submitted 90 days ago • 0 comments

The only thing I am missing here is Epigenetic Hulk account.

submitted 102 days ago • 0 comments

go.bsky.app/3wdSpdi It can be difficult to recreate your following list here, please comment/tag any other islet/panc people I am missing and I will edit the pack.

submitted 113 days ago • 7 comments