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Sequencing by Expansion (SBX) -- a novel, high-throughput single-molecule sequencing technology https://www.biorxiv.org/content/10.1101/2025.02.19.639056v1

submitted 5 days ago • 0 comments

PREPRINT OUT ✨ "hack" your microscope to work as a 3D printer! print micrometer sized features at cm scale. a method for easy and cheap microfabrication, with a focus on biological applications. THREAD ↓ www.biorxiv.org/content/10.1...

submitted 7 days ago • 9 comments

Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15) www.biorxiv.org/content/10.1...

submitted 18 days ago • 12 comments

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy www.biorxiv.org/content/10.1...

submitted 20 days ago • 15 comments

Made some slides for scientists to talk about what's been happening & what we should do next. There are probably many people better qualified than me to talk about these issues. If that's you, please, please, please consider holding some virtual advocacy training sessions for researchers this week.

submitted 20 days ago • 18 comments

Hi all, I am very excited to share two positions (PhD and PostDoc) in my group on a EU-funded project ProAct. More about the positions below. Please share with your colleagues! This will be a great project to work on and also we offer a great environment at the BIOS group

submitted 72 days ago • 1 comment

Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation www.cell.com/cell/fulltex...

submitted 27 days ago • 4 comments

Seeing ribosomes in action? Thanks to researchers from the @marvintanenbaum.bsky.social lab this is now possible. They created a technology to track individual ribosomes during mRNA translation. The team found that ribosomes ‘help’ each other in difficult situations www.hubrecht.eu/ribosomes-te...

submitted 29 days ago • 0 comments

#Jobs We are looking for a new colleague! Tenure Track Assistant Professor in Biophysics in the domains of functional imaging and biophysics. More info here: www.wur.nl/en/vacancy/a...

submitted 32 days ago • 0 comments

🧬🖥️ www.science.org/doi/10.1126/...

submitted 36 days ago • 1 comment

Time to leave Bolzano, and I do that with a sense of great admiration for the field of single molecule protein sequencing #SMPS2025. A superfast moving field, and I’m asked looking forward to the next edition in Thailand. Hopefully I can present our contributions then as well!

submitted 36 days ago • 1 comment

Great #SMPS4 conference dinner last night. Very last minute, we organized an impromptu band (@xiuqichen.bsky.social AmitMeller, JavierAlfaro, me) and rented musical instruments to play -as requested by the organizers- some tango music, where conference participants were invited to dance.

submitted 38 days ago • 3 comments

Our editor, Raghav Palankar @palankar.bsky.social, is at the Single Molecule Protein Sequencing 2025, Bolzano, IT. www.smps2025.com/program Raghav will be happy to discuss all things single-molecule and nano or chat over a coffee about what professional editors do at scientific journals. #SMPS4

submitted 40 days ago • 1 comment

Over the moon at #SMPS4 in Bolzano. Photographer @jritmejeris.bsky.social

submitted 40 days ago • 0 comments

Follow by Chirlmin Joo: Decoding protein-peptide interactions with a sequencing platform #SMPS4

submitted 41 days ago • 0 comments

Sonja Schmid from University of Basel talking about: Nanopore trapping for protein identification & beyond #SMPS4

submitted 41 days ago • 0 comments

New discovery from our #CDlab reported in Cell @cp-cell.bsky.social today: SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion! www.sciencedirect.com/science/arti... 1/

submitted 45 days ago • 2 comments

Day-1 workshop started #SMPS4

submitted 43 days ago • 0 comments

In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:

submitted 44 days ago • 7 comments

What a way to start 2025! Our review on the Known Unknowns of the Hsp90 Chaperone has been published! Huge thanks to Laura Silbermann and Benjamin Vermeer for all of their efforts, and to @scisonja.bsky.social for the great collaboration :) You can read it here: elifesciences.org/articles/102...

submitted 60 days ago • 2 comments

🚨 ANOTHER JOB OPENING 🚨 We are looking for a Chief Editor for a new @natureportfolio.bsky.social journal launching in 2026: Nature Sensors 🧪 📍 Berlin or New York 🗓️ Closing date: Jan 05, 2025 🙏 Re-posts very much appreciated! springernature.wd3.myworkdayjobs.com/SpringerNatu... #Chemsky

submitted 85 days ago • 0 comments

Pod5Viewer: a GUI for inspecting raw nanopore sequencing data. #Nanopore #SequencingData #Bioinformatics #Genomics @nanoporetech.com 🧬 🖥️ academic.oup.com/bioinformati...

submitted 87 days ago • 0 comments

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

submitted 88 days ago • 33 comments

Reply below if you want to be included in the #nanopore starter pack! go.bsky.app/VCoo6T

submitted 92 days ago • 14 comments

How are mRNAs recruited to the ribosome small subunit in bacteria? Super cool story highlighting the role of bS1. Long standing basic questions answered there 🔬 www.science.org/doi/10.1126/...

submitted 93 days ago • 1 comment

Hey @blueskystarterpack.com please add: go.bsky.app/VCoo6T

submitted 94 days ago • 1 comment

Who should you nominate as reviewers for your manuscript? After a long chat with a post-grad it appears that there's a lot of misguided advice out there. Thread 👇

submitted 100 days ago • 18 comments

Happy to share our latest review of #nanopore protein sequencing in Nature Reviews Bioengineering🎉! Fascinating breakthroughs in nanopore technology have emerged recently. We highlight these game-changing advances & envision the future of protein sequencing. Access link: rdcu.be/d0Zzu

submitted 101 days ago • 0 comments

First attempt in a (loosely defined) Single-Molecule Biophysics starter pack. Please share and (self-) nominate. go.bsky.app/CteFZM5

submitted 109 days ago • 66 comments