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yuvalsim.bsky.social
Assistant professor at the University of Chicago. Studying the population genetics of complex traits (mainly) and interested in using math to understand biology. Join my lab, where science is fun and traits are complex!
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My most recent preprint, currently working on revising (some review suggestions were very helpful!). This comes from my NSF PRFB postdoc project in Annalise Paaby’s lab, on C. elegans regulatory rules from doing the first (we think) ASE study in this system. www.biorxiv.org/content/10.1...

submitted 46 days ago • 0 comments

www.biorxiv.org/content/10.1... Smart study to test whether lower prediction accuracy in non-Europeans is due to between-population differences in population structure, genetic nurture, or assortative mating.

submitted 73 days ago • 0 comments

New work by Andy Dahl and Michal Sadowski on using GxE to study genetics of drug response now out in Cell Genomics www.cell.com/cell-genomic...

submitted 84 days ago • 0 comments

Excited to share a new preprint with @jnovembre.bsky.social ! We use a combination of population genetic theory, simulation, and data analysis to ask: how does study design in genetic studies (including biobanks) impact the discovery of rare, deleterious variants?

submitted 84 days ago • 2 comments

Very interesting work by Tade Souaiaia et al on the non-polygenic architecture of the extremes of complex traits. For many traits, polygenic scores show "regression to the mean" around the tails, as extreme traits are mostly due to rare alleles. www.biorxiv.org/content/10.1...

submitted 94 days ago • 1 comment

We are accepting applications for the 2025 Evolution Seminar Series Early Career Award here at UW-Madison. Deadline November 30. evolution.wisc.edu/seminars/ear... Please share with grad students and postdocs working in evolutionary biology!

submitted 104 days ago • 0 comments

Supplemental Figure 3. The demographic model

submitted 94 days ago • 0 comments

Optimist: The cup is half full. Pessimist: The cup is half empty. Population geneticist: The cup is either a quarter full or overflowing and I can never remember whether there's a factor of two for haploids or diploids. bsky.app/profile/hutc...

submitted 95 days ago • 2 comments

A reminder for new folks. BlueSky does not have an algorithm to raise posts of interest. It is incumbent upon you to do so via reposting. Liking things only provides feedback to the poster but does not promote the post. The signal to noise ratio is taking a brief beating, so great to help curate.

submitted 96 days ago • 5 comments

Going Blue feels like taking a fresh breath after a long nasty cold... Happy to have a place to read, share, and talk about science. Welcome home!

submitted 101 days ago • 0 comments