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zeinabrekad.bsky.social
Exploring RNA & RBPs in cancer: from cell edges to the chromatin. Microscopy lover, proteomics newbie. Likes computer sciences, physics & photography. Also an illustrator and graphic designer for Science and Biology (see: @Zeikad)
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Prolific Poster

Using public info, here's what we know about the soon to be released Orbitrap Excedion (most likely name thus far) at ASMS 2025: - ETD-enabled enhanced MS² - eDR for expanded MS1 dynamic range - up to 12,000 m/z detection - faster LC compatibility - improved low-abundance analyte detection

Using public info, here's what we know about the Orbitrap Astral Zoom (most likely name) for ASMS 2025: ⚡270Hz MS/MS acquisition speed with ion pre-accumulation 🔄Fast m/z switching with 2.5ms settling time 🔍TMT High Res mode 📊Up to 29% more ions per peptide detected vs old Astral

Delighted to share our latest work deciphering the landscape of chromatin accessibility and modeling the DNA sequence syntax rules underlying gene regulation during human fetal development! www.biorxiv.org/content/10.1... Read on for more: 🧵 1/16 #GeneReg 🧬🖥️

Interested in chromatin architecture?
 Checkout our new method - PCP - that can map genome organization as multi-way interactions as well as nucleosome footprint and nucleosome spacing at very high resolution. www.biorxiv.org/content/10.1...

Another super paper came out this week from Amit Kohli and Laura Waller on Ring deconvolution microscopy. This one is fairly technical, but essentially it's a computational approach that lets you do deconvolution when there is a spatially varying PSF. www.nature.com/articles/s41...

Cours avancé en analyse d'image labellisé @embo.org , à l' @embl.org en #Allemagne du 14 au 19 septembre 2025. 👉La date limite de candidature est fixée au 4 juin ! 👉 Le programme et les modalités d'application sont disponibles sur ce site: s.embl.org/bia25-01

Deaths from heart disease down 75%, that’s NIH. Deaths from stroke down 75%, that’s NIH. HIV/AIDS no longer a death sentence, that’s NIH. 99% of FDA approved drugs in the last decade, that’s NIH. Please show this video to anyone who doesn’t understand why the NIH is so important.

#RNAsky

I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs. Plant, Bacterial, Archaeal Non-model Bioeng Custom Lab Hardware Turn Key Genetic Design Please repost for reach 💚

Just a random thought: Journals are obviously not paying reviewers, then how about dropping all publication fees to whoever has reviewed a paper for said journal? As in: no money but a paper to paper repayment. (Of course the publication has to meet publishing criteria) #academic_sky

The do’s and don’ts of scientific image editing Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies. @sarareardon.bsky.social reports www.nature.com/articles/d41...

This time-lapse captures 17 hours of axonal growth from a chicken dorsal root ganglion explant, visualized through the actin cytoskeleton using live confocal imaging. I just submitted this video to the Nikon Small World in Motion competition. Today is the last day to upload yours! 😉 🧪

The timeline of co-transcriptional #mRNA processing and #modification may have to be revised: cleavage, termination, and #m6A deposition may occur earlier than most #splicing! Potential textbook changing study in bioRxiv by edueyras.bsky.social & Rippei Hayashi labs! www.biorxiv.org/content/10.1...

🧪🐡Incredibly happy to be sharing with you the 8th issue of our #STEMDORADO science magazine! The magazine is a free #STEM outreach project led by the fabulous Alina Chakraborty where scientists across all STEM disciplines contribute with articles, games and fun science activities for kids 9-14 yo

💥Exciting #Postdoc opportunity in my lab at @cruk-mi.bsky.social to study the role of #RNADynamics in cancer progression! ⏰Deadline: 07/05/25 Apply 👇 www.cruk.manchester.ac.uk/career/mi-24... ⏩ Please share this with your network. #CancerResearch #RNADynamics #RNAmodification #CRUK #postdoc

#RNAsky

Simultaneously targeting lysosomal enzyme and KRAS-MAPK pathway eradicates ... - goo.gl/alerts/p5KSjX #GoogleAlerts

This is brilliant! 😋 Almost 1 year ago I started to meal prep, since being a busy postdoc should not be a reason to eat junk food 5d a week. I am happy to have maintained my goal, but now I am even more happy to the prospect of getting recipe inspirations from fellow colleagues around the world!

✨ Stay tuned for episode 3 ! 🎧 Episode 1 is already out : bsky.app/profile/lone... 🎙️ Episode 2 is coming by the end of this month !

Last night was the 250th anniversary of Paul Revere's midnight ride to warn the Minutemen of approaching British troops. I want to take a moment to share an excerpt from the Declaration of Independence's grievances against King George III. Remind you of anyone?

Tracking the folding of RNA at its birth

💡Calling all visualisation enthusiasts - did you know Jalview can help you bring your alignments to life in more ways than one? Experience the beauty of molecular graphics with four 3D viewers - PyMol, UCSF Chimera, JMol and ChimeraX - all accessible from Jalview!

Native mass spectrometry enables real time characterization of MAPK phosphorylation cascade and impact of oncogenic RAS mutants on kinetics. doi.org/10.1038/s420...

Gentle reminder :-)

I am happy to share the latest paper from the lab. We detail a tripartite cell-free translation system based on the separation of mRNAs, ribosomes and ribosome-depleted cytoplasmic lysate from human cells, allowing for flexible reconstitution of translation reaction. #RNA #Ribosome

All you nuclear biologists out there: Here is a cautionary tale not to be fooled by peripheral organelle staining. It might just be that your antibody got trapped because it is "too good".

The Royal Microscopical Society @royalmicrosoc.bsky.social Data Analysis in IMaging (RMS DAIM), with the support of the @crick.ac.uk Crick and Partners Networking Fund, is organising a “Train the Trainers in Bioimage Analysis” workshop. 1/n

The moon is rising, so is my insomnia. Goodnight to those blessed with good sleep 😴. At least I have nice company tonight. #full_moon

Did you know… It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳 For details, visit our website: journals.biologists.com/jcs/pages/re...

Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this! So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work! www.cell.com/molecular-ce...

And on other news. My first contribution to science as a postdoc with @stirlingchurchman.bsky.social is out! We discuss the knowns and unknowns of post-transcriptional splicing. It was really fun to write with the great @karinechoquet

Cool! #RNA

TMT-based Multiplexed (Chemo)proteomics on the Orbitrap Astral Mass Spectrometer #MCP www.mcponline.org/article/S153...

Finally some order in the disordered regions of proteins? 😆 #IDRs #phase_separation

Genentech is hiring for 6 new positions! Individual job details below!👇 #ScienceJobs 1/8

🚨Job alert Very happy to share this cool opportunity to set up a lab in my previous institute. If you want to enjoy a fantastic living in the beautiful French Riviera whilst building a strong lab, this is the place to go! Send your application here: [email protected] #biology #research

Important to celebrate trainee victories: excited to have Holly Merta's @hollymerta.bsky.social paper out! We use TurboID sub-organelle proteomics to map the ER network. We find calmin/CLMN, an ER-to-actin tether regulating focal adhesions & cell motility. www.sciencedirect.com/science/arti...

A new publication from my lab a great work done with fantastic colleagues from #IGDR (Reynald Gillet’s team for all the cryoem work. pubmed.ncbi.nlm.nih.gov/40187343/

To me humans and plants are alike as certainly a bit of sun and water is essential for photosynthesis, only that for humans it produces creative energy and lots of new ideas...

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