I'm delighted to release the first half of my new textbook in human genetics: web.stanford.edu/group/pritch... "An Owner's Guide to the Human Genome: an introduction to human population genetics, variation and disease" - ThreadSky

jkpritch.bsky.social • 609 days ago

I'm delighted to release the first half of my new textbook in human genetics:
https://web.stanford.edu/group/pritchardlab/HGbook.html

"An Owner's Guide to the Human Genome: an introduction to human population genetics, variation and disease"

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skylepidus.bsky.social•609 days ago

That’s an incredible title.

mtferris.bsky.social•609 days ago

Very excited to see this. Appreciate you taking the time to synthesize the field.

mikelove.bsky.social•609 days ago

Wow! Thanks for posting online, will definitely share this around the graduate students

jkpritch.bsky.social•609 days ago

The book aims to provide a unified view of human variation, population genetics, human history and trait genetics / GWAS I wrote this partly because I find a lack of suitable readings for teaching, and partly to connect the popgen and statgen world views in an accessible format

jkpritch.bsky.social•609 days ago

Another goal is to show how quantitative thinking and theory can illuminate interpretation of biological data. Here's a reference page about useful numbers for human genome data:

jkpritch.bsky.social•609 days ago

Part 1 of the book includes an overview of human genomics; an introduction to human variation; modern DNA sequencing; and an introduction to human mutation. My undergrads are reading the variation chapter for tomorrow's lecture:

ctrlalttim.com•609 days ago

I'm doing the same thing -- assigning an in-progress textbook as readings for the class it's based on -- and the students are providing amazing feedback so far!

jkpritch.bsky.social•609 days ago

I also tackle human mutation, but with more of an evolutionary and human genetics focus than most other introductory materials:

jkpritch.bsky.social•609 days ago

Part 2 of the book tackles human population genetics. Some themes are familiar from other popgen texts, but I try to focus on building intuition and human examples in many cases. Here's a bit about the difference between forward-in-time and backward-in-time models:

jkpritch.bsky.social•609 days ago

We cover recombination and LD in depth, as it's often difficult to get intuition for these topics:

johnpackwood.bsky.social•266 days ago

Half? So you mean haploid...? 😀

jkpritch.bsky.social•255 days ago

No, that suggests that the second half will be nearly identical to the first half (let's hope not!)

charleston.bsky.social•609 days ago

Another year before I have to teach my class again, any chance the second half would be done and I can just use the textbook as is? 😅😅

jkpritch.bsky.social•608 days ago

next fall? Yes, possible.

You should ping me in advance. I'm happy to share bootleg versions for teaching. (Students are already reading from Part 3 even though it still needs some editing.)

bjcohenmd.bsky.social•609 days ago

Thank you for sharing. I am long overdue for a update in genetics.

gcbias.bsky.social•609 days ago

Congratulations! This looks really great.

jkpritch.bsky.social•609 days ago

Thank you, Graham! Very much appreciated!

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