mikelove.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

One thing still missing in many GWAS pipelines: chrX analysis... In this study from @ajhgnews.bsky.social, Mefford et al. explore X-GWAS across 48 UKBB traits and as expected, ~3% of trait heritability comes from chrX. Looks like it’s time we start doing this! www.cell.com/ajhg/fulltex...

submitted 10 hours ago • 0 comments

"The scientific research base of the United States of America is the research university. We made that decision 80 years ago. We don't have a Plan B." — Condoleezza Rice

submitted 1 day ago • 14 comments

These are not just grants. This is thousands of people who devoted their lives and careers - taking pay cuts, working long hours, living with uncertainty - all for the chance to try to make people's lives a bit better for you and your loved ones. This breaks my heart.

submitted 1 day ago • 2 comments

We have updated our preprint about 850,000 person UK-Danish haplotype sharing - sheding light on the rich history each person carries with them in their DNA and comparing this to historical records. Xiaolei Zhang postdoc in my group led this work. www.biorxiv.org/content/10.1...

submitted 1 day ago • 1 comment

We honor Dr. Curtis Harper, the first African American tenured faculty @unc-phco.bsky.social and pioneering toxicologist. His legacy inspires the Harper Lectureship. This year, we welcome Dr. Kizzmekia Corbett-Helaire, a trailblazing vaccine leader, continuing Harper’s commitment to excellence.

submitted 2 days ago • 1 comment

I wrote a quick application note on Tomtom-lite, a Python implementation of the Tomtom algorithm for comparing PWMs against each other. This implementation can be 10-1000x faster and, as a Python function, can be integrated into your workflows easier. www.biorxiv.org/content/10.1...

submitted 3 days ago • 2 comments

“I would like to cure brain cancer. I think that's not particularly controversial.” Be that as it may, the NIH terminated that scientist's grant. Here's a huge survey of the 2,500 grants that NIH has killed or delayed...so far. Gift link: nyti.ms/43Jz1yJ

submitted 2 days ago • 16 comments

Just passed a wonderfully diverse group of students clearly hyped after seeing the morning talk from Kizzy Corbett! You will never convince me this isn’t a beautiful thing to witness! 🙌🏾

submitted 2 days ago • 4 comments

Cuts have consequences, illustrated. As seen on TV 📺

submitted 3 days ago • 860 comments

Universities are not passive beneficiaries of government largesse. It is the federal government that depends on universities to conduct the research that keeps our nation healthy, safe and economically competitive.I discuss in the Washington Post. www.washingtonpost.com/opinions/202...

submitted 3 days ago • 2 comments

I loved this episode, and crazy I never heard of Borlaug. As a scientist I strongly connected with 2 things: 1/ the necessity of long-term research cycles to reach a breakthrough 2/ the notion that dogmas are sometimes (often?) wrong and it’s healthy to challenge them every now and then.

submitted 7 days ago • 0 comments

Richard Levins was born OTD in 1930. We treat a problem with multiple models, each with different simplifications but with a common biological basis. If we get similar results we have “a robust theorem…. Hence our truth is the intersection of independent lies.” 🐋🌱🦫🦋🧪 #EvoBio #PhilSci #HistSTM

submitted 5 days ago • 3 comments

Join this gathering of leaders in industry, academia, and the government to network while you increase your expertise in R. Register for in-person and virtual events: user2025.r-project.org/register useR! 2025 will be held Friday, August 8th to Sunday, August 10th at Duke University. #RStats

submitted 6 days ago • 0 comments

🖥️🧬 The new release (v0.13.0) of piscem is out. However, almost all changes here are transparent to the user (except for the need to rebuild the index before using the new version). I want to take a second to talk about something that often goes unappreciated. 1/x github.com/COMBINE-lab/...

submitted 6 days ago • 1 comment

It is a disservice to both those who study the non-neuroscience related components of the eye and those who study neuroscience per se. Does anyone else just feel… tired? Like, exhausted?

submitted 6 days ago • 4 comments

Walt Whitman was born OTD in 1819. Song of Myself is a singularly Darwinian poem. The re-placing of natural theological tropes in a thoroughly naturalistic setting is characteristic of both. 🧪🦫🦋🐋🌱#HistSTM #BookSky

submitted 6 days ago • 1 comment

Bioconductor moving to Zulip for community chat stat.ethz.ch/pipermail/bi...

submitted 6 days ago • 2 comments

"Our calculations suggest that the proposed budgetary cuts to the NIH will create a social cost that is 16 times greater than the savings that the administration is attempting to achieve." jamanetwork.com/journals/jam...

submitted 7 days ago • 11 comments

Industry friends, now is the time for MUCH more speaking out on behalf of academic colleagues under duress. Here are core open source methods that many of your products doubtlessly depend on either directly or indirectly (see en.wikipedia.org/wiki/HMMER) being abruptly defunded. Make noise.

submitted 8 days ago • 1 comment

I'm on a podcast! I had a blast talking with @lucystats.bsky.social and @epiellie.bsky.social on @casualinfer.bsky.social! We cover all sorts of fun things: {marginaleffects}, defining estimands, fixed vs. random effects, & how to teach all this stats stuff in accessible ways #databs #EpiSky #rstats

submitted 8 days ago • 4 comments

Up until June 2 (Monday) you can apply for scholarship to attend GBCC2025 at Cold Spring Harbor Laboratory. This is the Bioconductor / Galaxy joint conference at the end of June. You should submit a poster abstract to apply for scholarship. Scholarship details below.

submitted 8 days ago • 0 comments

HMMER is crucial to our modern understanding of protein biochemistry and has almost certainly generated at least a 10-fold return on investment for every dollar the US government has spent on funding it.

submitted 9 days ago • 0 comments

NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.

submitted 15 days ago • 35 comments

Sec. McMahon describes ED as “an agency that is responsibly winding down.” Meanwhile, House Republicans are seeking to pass legislation that would require it to dramatically ramp up to implement one of the most complicated set of changes in decades, setting off an implementation nightmare.

submitted 9 days ago • 0 comments

1/ You launched a long-running program... And forgot to use screen or tmux. Now you're terrified to close your terminal. I’ve been there. Here’s how to rescue it like a pro.

submitted 9 days ago • 1 comment

50+% cut to the US National Science Foundation budget is staggering. These include cuts for research in Chemistry. Physics, Geology, Math, Engineering, Computer Science. Scientific discoveries and training of our next generation of scientists and engineers are halved. How is that helping the US?

submitted 9 days ago • 1 comment

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...

submitted 10 days ago • 6 comments

This is an amazing learning project :). Also, I agree that if you're looking for a super fast and fun (and safe) language to learn, Rust has you covered! BFX is leading, I think, in Rust adoption in science; let's keep it that way!

submitted 9 days ago • 0 comments

I started tgv to learn Rust and building it has been unbelievably fun! If you wanna pick up a super fast and fun programming language, tgv is open for contribution! There aren't many bioinformatics tools built entirely by the community. If tgv can become one, I'll be so psyched

submitted 9 days ago • 1 comment

The war on science in the US is already having an effect on private sector research like AlphaFold. Bears repeating but the private sector builds on top of things created by academic research for the public good. This hurts everyone.

submitted 9 days ago • 2 comments

Genuinely... quite excited about this. I think I might have to install it just for old skool x new school kicks. (plus - great for controlled cloud environments!)

submitted 9 days ago • 0 comments