mikelove.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

"Sources said the administration is specifically considering a full termination of federal grant funding for the University of California and California State University systems." Pure vandalism. This could never happen in a country with functioning checks and balances.

submitted 2 days ago • 69 comments

New publication from @jiachengmiao.bsky.social and Qiongshi Lu lab github.com/qlu-lab/PIGEON

submitted 20 hours ago • 0 comments

“Focus on single gene effects limits discovery and interpretation of complex trait-associated variants” Very interesting preprint by Kathryn Lawrence @tamigj.bsky.social @sbmontgom.bsky.social good arguments to move beyond single-gene-at-a-time approaches 🧪🧬 www.biorxiv.org/content/10.1...

submitted 1 day ago • 1 comment

Also, Charlie's #VariantEffect25 talk is available here www.youtube.com/watch?v=johJ...

submitted 1 day ago • 0 comments

📣 Latest from the lab: Performance of deep-learning-based approaches to improve polygenic scores www.nature.com/articles/s41... Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.

submitted 3 days ago • 4 comments

The university of California is a powerhouse of innovation, healthcare, and social mobility for California and the US.

submitted 1 day ago • 6 comments

One thing still missing in many GWAS pipelines: chrX analysis... In this study from @ajhgnews.bsky.social, Mefford et al. explore X-GWAS across 48 UKBB traits and as expected, ~3% of trait heritability comes from chrX. Looks like it’s time we start doing this! www.cell.com/ajhg/fulltex...

submitted 2 days ago • 0 comments

"The scientific research base of the United States of America is the research university. We made that decision 80 years ago. We don't have a Plan B." — Condoleezza Rice

submitted 3 days ago • 17 comments

These are not just grants. This is thousands of people who devoted their lives and careers - taking pay cuts, working long hours, living with uncertainty - all for the chance to try to make people's lives a bit better for you and your loved ones. This breaks my heart.

submitted 4 days ago • 2 comments

We have updated our preprint about 850,000 person UK-Danish haplotype sharing - sheding light on the rich history each person carries with them in their DNA and comparing this to historical records. Xiaolei Zhang postdoc in my group led this work. www.biorxiv.org/content/10.1...

submitted 4 days ago • 1 comment

We honor Dr. Curtis Harper, the first African American tenured faculty @unc-phco.bsky.social and pioneering toxicologist. His legacy inspires the Harper Lectureship. This year, we welcome Dr. Kizzmekia Corbett-Helaire, a trailblazing vaccine leader, continuing Harper’s commitment to excellence.

submitted 4 days ago • 1 comment

I wrote a quick application note on Tomtom-lite, a Python implementation of the Tomtom algorithm for comparing PWMs against each other. This implementation can be 10-1000x faster and, as a Python function, can be integrated into your workflows easier. www.biorxiv.org/content/10.1...

submitted 5 days ago • 2 comments

“I would like to cure brain cancer. I think that's not particularly controversial.” Be that as it may, the NIH terminated that scientist's grant. Here's a huge survey of the 2,500 grants that NIH has killed or delayed...so far. Gift link: nyti.ms/43Jz1yJ

submitted 4 days ago • 18 comments

Just passed a wonderfully diverse group of students clearly hyped after seeing the morning talk from Kizzy Corbett! You will never convince me this isn’t a beautiful thing to witness! 🙌🏾

submitted 4 days ago • 4 comments

Cuts have consequences, illustrated. As seen on TV 📺

submitted 5 days ago • 863 comments

Universities are not passive beneficiaries of government largesse. It is the federal government that depends on universities to conduct the research that keeps our nation healthy, safe and economically competitive.I discuss in the Washington Post. www.washingtonpost.com/opinions/202...

submitted 5 days ago • 2 comments

I loved this episode, and crazy I never heard of Borlaug. As a scientist I strongly connected with 2 things: 1/ the necessity of long-term research cycles to reach a breakthrough 2/ the notion that dogmas are sometimes (often?) wrong and it’s healthy to challenge them every now and then.

submitted 9 days ago • 0 comments

Richard Levins was born OTD in 1930. We treat a problem with multiple models, each with different simplifications but with a common biological basis. If we get similar results we have “a robust theorem…. Hence our truth is the intersection of independent lies.” 🐋🌱🦫🦋🧪 #EvoBio #PhilSci #HistSTM

submitted 7 days ago • 3 comments

Join this gathering of leaders in industry, academia, and the government to network while you increase your expertise in R. Register for in-person and virtual events: user2025.r-project.org/register useR! 2025 will be held Friday, August 8th to Sunday, August 10th at Duke University. #RStats

submitted 8 days ago • 0 comments

🖥️🧬 The new release (v0.13.0) of piscem is out. However, almost all changes here are transparent to the user (except for the need to rebuild the index before using the new version). I want to take a second to talk about something that often goes unappreciated. 1/x github.com/COMBINE-lab/...

submitted 8 days ago • 1 comment

It is a disservice to both those who study the non-neuroscience related components of the eye and those who study neuroscience per se. Does anyone else just feel… tired? Like, exhausted?

submitted 8 days ago • 4 comments

Walt Whitman was born OTD in 1819. Song of Myself is a singularly Darwinian poem. The re-placing of natural theological tropes in a thoroughly naturalistic setting is characteristic of both. 🧪🦫🦋🐋🌱#HistSTM #BookSky

submitted 8 days ago • 1 comment

Bioconductor moving to Zulip for community chat stat.ethz.ch/pipermail/bi...

submitted 9 days ago • 2 comments

"Our calculations suggest that the proposed budgetary cuts to the NIH will create a social cost that is 16 times greater than the savings that the administration is attempting to achieve." jamanetwork.com/journals/jam...

submitted 9 days ago • 11 comments

Industry friends, now is the time for MUCH more speaking out on behalf of academic colleagues under duress. Here are core open source methods that many of your products doubtlessly depend on either directly or indirectly (see en.wikipedia.org/wiki/HMMER) being abruptly defunded. Make noise.

submitted 10 days ago • 1 comment

I'm on a podcast! I had a blast talking with @lucystats.bsky.social and @epiellie.bsky.social on @casualinfer.bsky.social! We cover all sorts of fun things: {marginaleffects}, defining estimands, fixed vs. random effects, & how to teach all this stats stuff in accessible ways #databs #EpiSky #rstats

submitted 10 days ago • 4 comments

Up until June 2 (Monday) you can apply for scholarship to attend GBCC2025 at Cold Spring Harbor Laboratory. This is the Bioconductor / Galaxy joint conference at the end of June. You should submit a poster abstract to apply for scholarship. Scholarship details below.

submitted 10 days ago • 0 comments

HMMER is crucial to our modern understanding of protein biochemistry and has almost certainly generated at least a 10-fold return on investment for every dollar the US government has spent on funding it.

submitted 11 days ago • 0 comments

NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.

submitted 17 days ago • 35 comments

Sec. McMahon describes ED as “an agency that is responsibly winding down.” Meanwhile, House Republicans are seeking to pass legislation that would require it to dramatically ramp up to implement one of the most complicated set of changes in decades, setting off an implementation nightmare.

submitted 11 days ago • 0 comments

1/ You launched a long-running program... And forgot to use screen or tmux. Now you're terrified to close your terminal. I’ve been there. Here’s how to rescue it like a pro.

submitted 11 days ago • 1 comment

50+% cut to the US National Science Foundation budget is staggering. These include cuts for research in Chemistry. Physics, Geology, Math, Engineering, Computer Science. Scientific discoveries and training of our next generation of scientists and engineers are halved. How is that helping the US?

submitted 11 days ago • 1 comment

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...

submitted 12 days ago • 6 comments

This is an amazing learning project :). Also, I agree that if you're looking for a super fast and fun (and safe) language to learn, Rust has you covered! BFX is leading, I think, in Rust adoption in science; let's keep it that way!

submitted 11 days ago • 0 comments

I started tgv to learn Rust and building it has been unbelievably fun! If you wanna pick up a super fast and fun programming language, tgv is open for contribution! There aren't many bioinformatics tools built entirely by the community. If tgv can become one, I'll be so psyched

submitted 11 days ago • 1 comment