It was a long journey, where I led this study through 2 postdocs & did some revisions in my new lab @dzne.science. Thanks to @Michael Heneka & @Eicke Latz, & all our collaborators across Germany, Luxembourg, Northern Ireland, Spain, Sweden, Switzerland and USA (2) - ThreadSky

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roisinmcmanus.bsky.social • 133 days ago

It was a long journey, where I led this study through 2 postdocs & did some revisions in my new lab @dzne.science. Thanks to @Michael Heneka & @Eicke Latz, & all our collaborators across Germany, Luxembourg, Northern Ireland, Spain, Sweden, Switzerland and USA (2)

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roisinmcmanus.bsky.social•133 days ago

Thanks to the reviewers and editors @cellpress.bsky.social for their insightful comments and helpful suggestions (3)

roisinmcmanus.bsky.social•133 days ago

From my side this work would not have been possible without generous support from @afi-ev.bsky.social, @immunosens.bsky.social , @sfb1454.bsky.social @dfg.de and the @alzassociation.bsky.social (4)

roisinmcmanus.bsky.social•133 days ago

If you’re curious whether this mechanism is relevant for other pathways or cell function, stay tuned for our next story from the McManus lab that we will be submitting soon! (5)

roisinmcmanus.bsky.social•133 days ago

A thread on our main findings:
During my postdoc I noticed something surprising, where NLRP3-/- microglia were much better at #phagocytosis than wild-type cells even under basal (unstimulated) conditions (6)

roisinmcmanus.bsky.social•133 days ago

To uncover what was driving this, we did single cell RNAseq. This unveiled a population of NLRP3-/- microglia with a strong metabolic and phagocytic signature, and the most significantly changed gene was the glutamate transporter Slc1a3 (7)

roisinmcmanus.bsky.social•133 days ago

SLC1A3 is well characterised on astrocytes. To verify the expression changes we performed bulk RNAseq on different NLRP3-/- microglia ex vivo and again saw an increase in microglial Slc1a3 (8)

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