...if the current trend of antigenic drift marked by gradual accumulation of slight antigenic changes continues. Of course, a completely novel variant could arise & spread at any time, which would totally change the picture. Or... - ThreadSky

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ryanhisner.bsky.social • 8 days ago

...if the current trend of antigenic drift marked by gradual accumulation of slight antigenic changes continues.

Of course, a completely novel variant could arise & spread at any time, which would totally change the picture. Or...

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ryanhisner.bsky.social•8 days ago

...the marginal, stepwise changes in spike might at some point enable a novel mutation to arise through epistasis, which is what happened last year. Q493E caused an unviably large drop in ACE2 affinity on a JN.1 spike background, but when F456L was added, Q493E actually increased ACE2 affinity.

ryanhisner.bsky.social•8 days ago

Tyler Starr and @jbloomlab.bsky.social did great work illustrating this, though it looks like the threads on Q493E epistasis are all on Twitter. https://x.com/tylernstarr/status/1800315113037336671

flodebarre.bsky.social•8 days ago

Tyler Starr is here as well, no need to go back to the neo-Nazi place :-)
@tylernstarr.bsky.social

ryanhisner.bsky.social•7 days ago

Oh, wow thanks. I tried to look up Tyler Starr, that account didn't show up. I don't know why the search engines at these places are so bad.

tylernstarr.bsky.social•7 days ago

I only joined a month or two ago! and haven’t been posting much though have been enjoying my timeline here, cleanse from twitter 😂

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