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angrist.bsky.social
•
13 days ago
Do you think it can also be used with metabolites?
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cashwood.proteaglyco.com
•
13 days ago
That’s where I learned about Thermo’s eDR application of a similar approach, metabolomics.
They only use two “boxes” instead of the six you see here.
Optimal number of boxes, box width and m/z centre are likely analyte dependent.
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angrist.bsky.social
•
13 days ago
From what I understand, I should be able to adapt it without compromise, even to short gradients (in proteomics). Do you agree?
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cashwood.proteaglyco.com
•
12 days ago
Yes, I agree.
Though won’t be a great method if you’re not hitting the AGC target early (based on maximum injection time).
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angrist.bsky.social
•
12 days ago
So, for small quantities, it could have problems?
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angrist.bsky.social
•
12 days ago
or maybe even in that case it will be possible to optimize the times to allow for greater sensitivity
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cashwood.proteaglyco.com
•
12 days ago
I’m not sure, only tried it a little in lab.
One of the authors, @searleb.bsky.social, will be able to answer your question better.
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They only use two “boxes” instead of the six you see here.
Optimal number of boxes, box width and m/z centre are likely analyte dependent.
Though won’t be a great method if you’re not hitting the AGC target early (based on maximum injection time).
One of the authors, @searleb.bsky.social, will be able to answer your question better.