adamezracohen.bsky.social
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Yes, and mine is terminated because we're trying to punish antisemites. Kafka couldn't do better if he tried.
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Led by Nate Lord, with @harrymcnamara.bsky.social, Alison Guyer, Bill Jia, Vicente Parot, Caleb Dobbs, and Alex Schier.
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Yeah, there's a thin ring btwn the coarse focus knob and the microscope body. On one side of the microscope this sets the upper limit to the focus, the other side sets the friction in the focus train. Increase the friction.
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Discussing the findings in our recent paper on dendritic voltage imaging in acute brain slices:
www.nature.com/articles/s41...
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Sure. Easy to map potentiated spine density across space. If the expression density is high, the challenge is to trace from the spines along the dendrites back to the parent cell. That would require some sort of high resolution connectomics. Totally plausible, but that would be a project.
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Not yet. The problem is we don't know the identity of the presynaptic cells; and typically only a tiny fraction of synapses are potentiated. We (or somebody) should do this in a slice LTP assay.
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How about this one?
www.nature.com/articles/s41...
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On my lab's website :)
cohenweb.rc.fas.harvard.edu/Publications...
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The claim that the destruction of essential civilizational institutions is being done in the name of the Jews is itself a form of antisemitism—cultural vandalism carried out in our name.
That, my friends, is rank bullshit.
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Very happy that we coordinated so the two papers hatched at the same time.
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Also check out the related work led by Boaz Mohar. Pulse-chase labeling with permeable HaloLigand dyes probes protein turnover. www.nature.com/articles/s41...
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Doyeon found a surprisingly tight linkage between synaptic plasticity and cFos expression in the hippocampus. This connects the synaptic and cell-based engram literatures (which to me always seemed to be talking past each other).
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Led by the amazing Doyeon Kim, with a lot of HaloLigand dyes and chemistry guidance from Luke Lavis.
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Equipment vendors sometimes hide batteries inside equipment to ensure finite lifetime, so labs keep coming back to buy more equipment. Next time your equipment fails, look inside for hidden batteries (or sometimes hard-soldered fuses) before tossing in the trash. Combat corporate greed!
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And I just learned that Katherine has a bsky account: @kxiang.bsky.social
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People usually assume that vascular endothelial Ca2+ dynamics are driven by blood flow-induced shear forces; but at least in a 5 dpf zfish, body motion is the key. www.biorxiv.org/content/10.1...
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We'd love feedback, or contributions to the code!
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The key features are hardware-level registration of stimulation and recording parameters in space and time, and easy design of complex multi-parameter experiments.
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We use this code in almost all our projects, from optical electrophysiology to magnetochemistry to developmental biology.
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The code is open-source, and has a website! Many thanks to Hunter Davis, Raffi Hotter, Phil Brooks, Daniel Itkis and many others for making this beautiful software.
www.luminosmicroscopy.com
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There are several exciting recent results on coherent spin dynamics in proteins:
arxiv.org/abs/2411.16835
and
www.biorxiv.org/content/10.1...
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The key step goes through quantum coherent evolution of a spin-correlated radical pair. Katherine's data and model provide a roadmap for studying and engineering magnetic field effects in biology, creating genetically encoded Qubits, and possibilities for quantum coherent control in proteins.
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Katherine worked out the photocycle, measured the rates, and built a quantitative model which reproduces her data in purified protein and in live E. coli.
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Bizarrely, the effect goes away in purified protein, but reappears if you add flavin mononucleotide (FMN) and blue light. Katherine showed that a long-lived oxygen-sensitive FMN photoproduct is necessary for the magnetic field effect. The mystery ingredient is FMNH_2.
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Weak magnetic fields can induce >20% changes in the fluorescence of mScarlet3 in E. coli! It's not a subtle effect.
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This is inspired by work from @mariaingaramo.bsky.social and @andrewgyork.bsky.social (andrewgyork.github.io/gfp_magnetof...)