alextisyoung.bsky.social
Asst. Prof. @ UCLA Human Genetics. Statistical geneticist & part of the SSGAC. Mendelian inheritance is the most important natural experiment. alextisyoung.github.io
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Prolific Poster
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Yeah isn't this exactly what one would expect and similar to things like bmi?
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I see. Well yes but it might be tricky because inherited variants would tend to have smaller effect sizes than de novos independently of assortment.
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I'm not sure why assortment would affect this?
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When there is assortment, common and rare variant contributions will become correlated and this needs to be taken into account when analyzing either.
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This paper provides the first direct evidence of this by showing a surprisingly large correlation between the common variant education polygenic score and a rare variant burden score.
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It's possible that this is because the parents' genetics affect the offspring through the env but it could be assortment: parents with lower education polygenic scores based on common variants are more likely to mate with individuals with rare variants that cause neurodevelopmental conditions.