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amarsahay.bsky.social
Professor @ MGH & Harvard Medical School. Hippocampus + Cognition. www.sahaylab.com Engineering strategies to restore, maintain and enhance cognition since 2011. Marathoner. Shark diver. Husband. Dad of human and wirehaired doxies
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Run those miles and let the miles enjoy running with you..

submitted 1 day ago • 1 comment

A pair of leather gloves worn by President Abraham Lincoln to Ford’s Theater on the night of his assassination fetched $1.5 million at auction this week.

submitted 5 days ago • 82 comments

Check out the neuroview and all the great articles of new tools to target different cell types with enhancer-mediated AAVs!

submitted 8 days ago • 0 comments

www.cell.com/cell/fulltex...

submitted 7 days ago • 0 comments

Good luck KJ!! Their work — kept secret until now — is likely the fastest-ever creation of a new drug, and the first time that any patient has received a truly bespoke gene editing treatment to fix the root cause of their disease. endpts.com/philadelphia...

submitted 14 days ago • 1 comment

hbr.org/2025/05/in-u...

submitted 14 days ago • 0 comments

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

submitted 15 days ago • 18 comments

Hey @jacksonlab.bsky.social & neurotwitter, Have you had issues with this amyloidosis mouse line: B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax, Stock No: 005864. Only 30% of 11 month old Heterozygous Tg mice show plaques???

submitted 17 days ago • 0 comments

Sahay lab (www.sahaylab.com) is seeking applications for a 10 week long summer research internship from undergraduates (US Citizen/ F1 Visa holder) for 2 Center for Curiosity funded "Curiosity Scholars in Neuroscience”. 1/n

submitted 21 days ago • 1 comment

Urnov thinks it’s possible to be cautious to a fault and says that most severe safety issues from gene therapies weren’t predicted from animals. “The number one thing our field needs is more clinical data. The only way to find out how to safely gene edit people is to edit more people,” he told me.

submitted 20 days ago • 0 comments

Sahay lab (www.sahaylab.com) is seeking applications for a 10 week long summer research internship from undergraduates (US Citizen/ F1 Visa holder) for 2 Center for Curiosity funded "Curiosity Scholars in Neuroscience”. 1/n

submitted 21 days ago • 1 comment

Anyone know if Pioneer or TR01 mechanisms will be resurrected?

submitted 22 days ago • 0 comments

Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear. @pavelbarahtjan.bsky.social addresses this question: www.biorxiv.org/content/10.1...

submitted 23 days ago • 6 comments

Blistering clay court match!

submitted 25 days ago • 0 comments

As someone who respects and tries to learn from SC Bench’s rulings, a fun evening w/ Stephen Breyer on Textualism v. Pragmatism. Takeaways: 1. The SC 9 give each case their objective, unbiased critique. 2. Participate in public life. 3. Differences in opinion is why SC works 4. USA will endure..

submitted 25 days ago • 0 comments

Synaptic vesicle-omics in mice captures signatures of aging & synucleinopathy; Synaptic changes in mice lacking α-synuclein suggest that loss of α-synuclein function contributes to synaptic dysfunction www.nature.com/articles/s41...

submitted 26 days ago • 0 comments

Communicating the beauty and power of science to transform health in a way that is understandable to all. And starting young (high schoolers) Thanks @khanacademy.org Ask your congress rep to share. youtu.be/746lnru2lGw

submitted 26 days ago • 0 comments

“For any new grant issued, and for all existing grants to IHEs retroactive to the date of issuance of this Supplemental Guidance, award recipients are subject to a 15 percent indirect cost rate.”

submitted 27 days ago • 0 comments

Watching humans savor that ice cream..

submitted 27 days ago • 0 comments

Hues. Transient. Like Spring.

submitted 27 days ago • 0 comments

Morning run musing: Genetic LOF/GOF tools have led to a plethora of phenotypes for genes at expense of understanding of MOA. People conflate phenotypes with mechanism. We need to integrate biochemistry, physiology and mol bio with genetics to understand mechanisms underlying phenotypes.

submitted 28 days ago • 1 comment

Morning trail run..

submitted 30 days ago • 0 comments

Morning hues. Thinking of ..

submitted 31 days ago • 0 comments

Check out this cool work from my superstar student Elie developing a new dimensionality reduction algorithm that compares two conditions! It works on many types of data

submitted 41 days ago • 1 comment

www.nature.com/articles/171... Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid | Nature 4/25/1953

submitted 34 days ago • 0 comments

Morning light. Birds chirping. Deliberation and digressions. The munificence of spring.

submitted 35 days ago • 0 comments

While many CRISPR companies in the US are focused on a single gene editing technology, HuidaGene has developed a deep toolkit, including Cas12 enzymes for DNA cutting and Cas13 for RNA knockdown, plus tools for base editing and epigenetic editing. endpts.com/china-biotec...

submitted 37 days ago • 1 comment

How the morning began.. 250 years later April 19, 2025. Reenactment of Revolutionary war, Lexington, MA 1/n

submitted 40 days ago • 1 comment