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Focus on single gene effects limits discovery and interpretation of complex trait-associated variants https://www.biorxiv.org/content/10.1101/2025.06.06.658175v1

submitted 7 hours ago • 0 comments

The CYP71A, NIT, AMI, and IAMH gene families are dispensable for indole-3-acetaldoxime-mediated auxin biosynthesis in Arabidopsis https://www.biorxiv.org/content/10.1101/2025.06.03.657619v1

submitted 10 hours ago • 0 comments

Tetraploid turnips (Brassica rapa ssp. rapa) are highly tolerant of tetravalent formation and aneuploidy https://www.biorxiv.org/content/10.1101/2025.06.04.657904v1

submitted 11 hours ago • 0 comments

Assessing the adaptative potential to temperature and precipitation along a steep environmental gradient in populations of European beech https://www.biorxiv.org/content/10.1101/2025.06.03.657567v1

submitted 11 hours ago • 0 comments

Unlocking the Forgotten Dimension of Biodiversity: A Scalable Genetic Diversity Index for Multi-Species Analysis https://www.biorxiv.org/content/10.1101/2025.06.03.657643v1

submitted 18 hours ago • 0 comments

Comprehensive molecular impact mapping of common and rare variants at GWAS loci https://www.biorxiv.org/content/10.1101/2025.06.05.658079v1

submitted 1 day ago • 0 comments

Establishing a DNA reference library for the identification of elasmobranchs in the Indian Ocean using Oxford Nanopore Sequencing https://www.biorxiv.org/content/10.1101/2025.06.03.657733v1

submitted 1 day ago • 0 comments

Leech Speciation and Detection of Hirudin Gene among the Leech Population in Asejire Oyo State, Nigeria https://www.biorxiv.org/content/10.1101/2025.06.02.657427v1

submitted 2 days ago • 0 comments

Isolation of Cyclotide Gene from Solanaceae Family and Its Bioinformatics Analysis https://www.biorxiv.org/content/10.1101/2025.06.02.657358v1

submitted 2 days ago • 0 comments

The Insertion of an ATTTC Repeat in an Alu Element Hyperactivates a Primate-Specific Neurodevelopmental Enhancer in Spinocerebellar Ataxia Type 37 https://www.biorxiv.org/content/10.1101/2025.06.03.657633v1

submitted 2 days ago • 0 comments

Impact of trait measurement error on quantitative genetic analysis of computer vision derived traits https://www.biorxiv.org/content/10.1101/2025.06.02.657462v1

submitted 2 days ago • 0 comments

A cross-species rescue by mating method to interrogate gene essentiality across the Saccharomyces genus. https://www.biorxiv.org/content/10.1101/2025.06.02.657496v1

submitted 2 days ago • 0 comments

Unisexual reproduction in the global human fungal pathogen Cryptococcus neoformans https://www.biorxiv.org/content/10.1101/2025.06.02.657540v1

submitted 3 days ago • 0 comments

An intergenerational lipid memory of the social environment in C. elegans https://www.biorxiv.org/content/10.1101/2025.06.03.657568v1

submitted 3 days ago • 0 comments

Desmoplakin Haploinsufficiency Underlies Cell-Cell Adhesion Failure in DSP Cardiomyopathy and is Rescued by Transcriptional Activation https://www.biorxiv.org/content/10.1101/2025.06.01.657304v1

submitted 3 days ago • 0 comments

An α-1,3-fucosyltransferase influences thermal nocifensive escape behaviors in Drosophila larvae https://www.biorxiv.org/content/10.1101/2025.06.02.657458v1

submitted 3 days ago • 0 comments

Meiotic null MSH2 and SGS1 alleles in S. cerevisiae x S. uvarum hybrids result in near-haploid offspring with mixed parental chromosomal inheritance https://www.biorxiv.org/content/10.1101/2025.06.02.657486v1

submitted 3 days ago • 0 comments

Increased Genetic Protection Against Alzheimer's Disease in Centenarians https://www.biorxiv.org/content/10.1101/2025.06.02.657442v1

submitted 4 days ago • 0 comments

Exon-skipping and genetic compensation due to biallelic mutations in the neurodevelopmental disease gene LNPK https://www.biorxiv.org/content/10.1101/2025.05.30.656906v1

submitted 4 days ago • 0 comments

Time Series GWAS for Iron Deficiency Chlorosis Tolerance in Soybean using Aerial Imagery https://www.biorxiv.org/content/10.1101/2025.05.30.657051v1

submitted 4 days ago • 0 comments

A curated dataset and web application for Integrative Analysis of Ancient DNA from Britain and Ireland https://www.biorxiv.org/content/10.1101/2025.05.30.657009v1

submitted 4 days ago • 0 comments

Nonequivalence of Zfp423 premature termination codons in mice. https://www.biorxiv.org/content/10.1101/2025.05.30.656936v1

submitted 4 days ago • 0 comments

A NEW DYSTROPHIN DEFICIENT RAT MODEL MIRRORING EXON SKIPPING IN PATIENTS WITH DMD EXON 45 DELETIONS https://www.biorxiv.org/content/10.1101/2025.05.30.656540v1

submitted 5 days ago • 0 comments

Single-cell Characterization of DNA Hydroxymethylation of the Mouse Brain During Aging https://www.biorxiv.org/content/10.1101/2025.05.29.656780v1

submitted 5 days ago • 0 comments

Biological characteristics of rabbit KLF12 and its regulation of proliferation and apoptosis of ovarian granulosa cells https://www.biorxiv.org/content/10.1101/2025.05.29.656763v1

submitted 5 days ago • 0 comments

How to enviromically predict breeding genotypes as if they were commercial cultivars? https://www.biorxiv.org/content/10.1101/2025.05.28.656616v1

submitted 5 days ago • 0 comments

Global epistasis in budding yeast driven by many natural variants whose effects scale with fitness https://www.biorxiv.org/content/10.1101/2025.05.28.656710v1

submitted 5 days ago • 0 comments

KLHL41 orchestrates sarcomere assembly and size to drive skeletal muscle hypertrophy in vivo https://www.biorxiv.org/content/10.1101/2025.05.30.655367v1

submitted 6 days ago • 0 comments

A primate model organism for cardiac arrhythmias identifies a magnesium transporter in pacemaker function https://www.biorxiv.org/content/10.1101/2025.05.28.655959v1

submitted 6 days ago • 0 comments

An atlas of TF driven gene programs across human cells https://www.biorxiv.org/content/10.1101/2025.05.30.657075v1

submitted 6 days ago • 0 comments

Altered Hepatic Metabolism in Down Syndrome https://www.biorxiv.org/content/10.1101/2025.05.27.656393v1

submitted 7 days ago • 0 comments

Induced Proteinuria Enhances Adeno-Associated Virus Transduction of Renal Tubule Epithelial Cells After Intravenous Administration https://www.biorxiv.org/content/10.1101/2025.05.28.656514v1

submitted 7 days ago • 0 comments

REMEDY: REpair of heterozygous Mutations independent of Exogenous Donor template with high efficiency using allele specific CRISPR targeting and HDR enhancers https://www.biorxiv.org/content/10.1101/2025.05.29.641201v1

submitted 7 days ago • 0 comments

CRISPR-Cas9 repair complexity in Drosophila melanogaster: NHEJ-induced deletions and HDR variability in the bantam microRNA gene https://www.biorxiv.org/content/10.1101/2025.05.29.656857v1

submitted 7 days ago • 0 comments

Fine-Resolution Asymmetric Migration Estimation https://www.biorxiv.org/content/10.1101/2025.05.29.656894v1

submitted 8 days ago • 0 comments

Mechanisms and timing of programmed DNA elimination in songbirds https://www.biorxiv.org/content/10.1101/2025.05.26.656170v1

submitted 8 days ago • 0 comments

Cohesin sumoylation is required for repression of subtelomeric gene expression in Saccharomyces cerevisiae. https://www.biorxiv.org/content/10.1101/2025.05.26.656218v1

submitted 8 days ago • 0 comments

Methyl Nicotinate Is a Novel Geroprotective Compound That Promotes Mitochondria Dependent Lifespan Extension https://www.biorxiv.org/content/10.1101/2025.05.26.656117v1

submitted 8 days ago • 0 comments

Genetic regulation of fatty acid content in adipose tissue https://www.biorxiv.org/content/10.1101/2025.05.28.655990v1

submitted 8 days ago • 0 comments

H3K4me2 orchestrates H2A.Z and Polycomb repressive marks in Arabidopsis https://www.biorxiv.org/content/10.1101/2025.05.26.656066v1

submitted 9 days ago • 0 comments

Functionally significant, novel variants of BMP4 are associated with isolated congenital heart disease https://www.biorxiv.org/content/10.1101/2025.05.26.656099v1

submitted 9 days ago • 0 comments

Robust Serum Proteomic Signatures of APOE2 https://www.biorxiv.org/content/10.1101/2025.05.24.655950v1

submitted 9 days ago • 0 comments

Functional characterization of pathogenic SATB2 missense variants identifies distinct effects on chromatin binding and transcriptional activity https://www.biorxiv.org/content/10.1101/2025.05.28.656698v1

submitted 9 days ago • 0 comments

Intriguing relationship between chromosome I nuclear aneuploidy and mitochondrial intron deletion in yeast https://www.biorxiv.org/content/10.1101/2025.05.25.656015v1

submitted 9 days ago • 0 comments

Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood https://www.biorxiv.org/content/10.1101/2025.05.25.655566v1

submitted 9 days ago • 0 comments

The Genetic and Evolutionary Landscape of Pentanucleotide Tandem Repeats in Human Genomes https://www.biorxiv.org/content/10.1101/2025.05.27.656002v1

submitted 10 days ago • 0 comments

Enhancing Wnt signaling lowers fracture incidence in a severe mouse model of Osteogenesis Imperfecta https://www.biorxiv.org/content/10.1101/2025.05.27.656429v1

submitted 10 days ago • 0 comments

Rapid gain and loss of a chromosome drives key morphology and virulence phenotypes in Histoplasma, a fungal pathogen of humans https://www.biorxiv.org/content/10.1101/2025.05.23.655702v1

submitted 10 days ago • 0 comments

Multimodal analysis of in vitro hematopoiesis reveals blood cell-specific genetic impacts on complex disease traits https://www.biorxiv.org/content/10.1101/2025.05.23.655825v1

submitted 10 days ago • 0 comments

Scaled multidimensional assays of variant effect identify sequence-function relationships in hypertrophic cardiomyopathy https://www.biorxiv.org/content/10.1101/2025.05.23.655878v1

submitted 10 days ago • 0 comments