cassiemanrique.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

So thankful to have spent the past week in Puerto Rico at #2025ICDB #2025SDB! 🌴 This was my first conference outside of NYC, and it was great to hear from so many renowned developmental biologists and receive feedback on my research.

submitted 2 days ago • 0 comments

PSA: around 5-8% of the population has a color vision impairment for red/green. Many talks at #2025ICDB still use red-green LUTs on slides that are not accessible to everyone. Changing to more accessible colors is doable and easy. We can do better. #devbio #ICDB2025 #WeTheColorBlind

submitted 6 days ago • 6 comments

So excited to be in Puerto Rico for #2025ICDB #2025SDB! Come visit me at my poster (#C36) Saturday to hear about multi-omic sequencing to mature hPSC-derived skeletal muscle, and see my lab mate and friend Isabelle’s talk (session 4.1) on lamin B loss in muscle nuclei! 💪

submitted 7 days ago • 0 comments

Freckles would like to remind everyone to VOTE in your local elections! 🗳️ They might not be as publicized as federal elections, but local and state elections influence your schools, taxes, infrastructure, and more.

submitted 16 days ago • 0 comments

My ongoing request: If your NSF or NIH grant was terminated--whether at Harvard or elsewhere--please report it here. NSF: grant-watch.us/submit-nsf.h... NIH: grant-watch.us/submit-nih.h... Our trackers are actively used in lawsuits and are often the only record that terminations ever occurred.

submitted 42 days ago • 16 comments

PSA: We just finished processing nearly all public ATAC-seq datasets from SRA (about 22,000 datasets). (Not?) Surprisingly, we had to throw-out nearly ~50% because they were low-quality (low signal-to-noise, duplicate rate, etc.). Check quality before analysis (TSS-enrichment is not sufficient!).

submitted 43 days ago • 6 comments

The basic subunit of chromatin, the nucleosome, consists of a segment of DNA wrapped around eight HISStone proteins 🐱

submitted 51 days ago • 0 comments

Which FDA-approved vaccines had randomized, placebo-controlled trials? ALL OF THEM. Polio? Measles, mumps, rubella? Haemophilus influenzae B? Diphtheria, tetanus, pertussis? Meningococcus? Varicella? Pneumococcus? Rotavirus? RSV? Hepatitis B? Influenza? HPV? COVID-19? Shingles? YEP. A thread🧵 1/

submitted 52 days ago • 60 comments

The average American has 3 friends

submitted 55 days ago • 4 comments

An important point getting overlooked: When NIH cancels "diversity" grants (e.g., diversity supplements, Fs, Ks, etc), they aren't canceling the grants based on what the grant studies. They're cancelling them based on who is doing the research. And that disallowed "who" is anyone not white.

submitted 82 days ago • 82 comments

Live thread on @60minutes.bsky.social coverage of #NIH. First, it’s ironic that one of the first commercials was for Keytruda, the cancer therapy developed with heavy NIH investment over decades. Without NIH, there would be no Keytruda. 1/ 🧵

submitted 59 days ago • 5 comments

I'm sorry, but rich, privileged women going on a space fieldtrip is not inspiring. The people are who ARE inspiring are the hardworking women working in STEM. You know, the ones who are at risk of losing their jobs and grants. #SaveOurScience

submitted 71 days ago • 40 comments

Does anyone know what software/packages generate these nice color-coded visualizations of structural rearrangements (this one from Jeong et al. 2025 Nature Genetics)?

submitted 72 days ago • 3 comments

Petabytes of critical government research that is marked for possible deletion cannot be archived because of technical and legal restrictions, meaning it is very likely to be lost forever: www.404media.co/nih-archives...

submitted 82 days ago • 191 comments

All staff at the NIH Office of Pain Policy and Planning were let go due to today's cuts. This devastating loss will have significant negative impacts on the health of millions. Pain is the leading cause of disability and the top reason for seeking medical care.

submitted 85 days ago • 0 comments

we need a totally revised constitution and I think we should call it the Consti2tion

submitted 83 days ago • 19 comments

I'm not a "we should teach every kid to code" person but dear lord can we at least teach basic computational concepts or something, this is embarrassing

submitted 100 days ago • 3 comments

My F31 diversity keeps getting unassigned and reassigned and unassigned to study section… all this limbo is so nerve wracking (especially for young scientists whose first experience with funding submissions and the NIH is this).

submitted 104 days ago • 1 comment

TO: <ALL STAFF> Please respond to this email confirming that I am cool and funny. Failure to do so will be taken as confirmation of the same.

submitted 123 days ago • 133 comments

ATTENTION (PLEASE SHARE) If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread. There are lots of talented and accomplished people who may be looking for new opportunities.

submitted 130 days ago • 92 comments

Happy International Day of Women in Science. The National Science Foundation’s list of flagged words includes both “Women” and “Female.”

submitted 134 days ago • 29 comments

Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify Sign the Petition: chng.it/kK2HMP5pGk "Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."

submitted 135 days ago • 9 comments

not paying indirect costs for research is like only paying the players in the Super Bowl. can't have a Super Bowl without coaches, referees, security, janitors, announcers, stadium staff, and a stadium - and you can't have research without supporting people and facilities

submitted 136 days ago • 19 comments

Total NIH funding cuts by state. This can be helpful when talking to your representatives www.datawrapper.de/_/Y0Pnk/

submitted 136 days ago • 6 comments

🚨 Revised request for scientist friends who want to do something to help 🚨 Help me find scientific professional societies with significant numbers of US members so I can approach them about a sign-on letter. What societies are you a member of? Send me names, links, etc. DMs open. 🧪🌎🦑

submitted 138 days ago • 66 comments

Somewhere in the U.S., there’s a scientist staring at their NSF/NIH grant application wondering why they bother. This post is for you. Science and society both need you. Hang in there and know there is a whole community supporting you.

submitted 147 days ago • 42 comments

DO YOU EVER LOOK AT CATS AND WONDER HEY WHY DOES THIS LITTLE ANIMAL LIVE IN MY HOUSE? WHAT IS IT DOING? HOW DID I GET SO LUCKY?

submitted 152 days ago • 584 comments

Artists, I have some questions for you. Let's say, hypothetically, there was a science conference coming to your city, all about animals. The scientists are looking for artists to come to the meeting, sit in on the talks, & live-Illustrate what you learn about. This would be paid. My questions...

submitted 167 days ago • 122 comments

HAPPY NEW YEAR EVERYONE BEST WISHES FOR 2025 BE KIND, INCLUDING TO YOURSELF SIT IN MULTIPLE BOXES AT ONCE REMEMBER THAT EVEN A TINY GLEAM WILL LIGHTEN THE DARKNESS

submitted 176 days ago • 35 comments

Without downloading new pics, what’s your energy going into 2025? (This was Freckles this summer, disoriented and hungry after having dental work done)

submitted 176 days ago • 0 comments

Hey microscopy people! Is it my turn to use the New Year's super resolution joke? Or did one of you want to take it this year?

submitted 177 days ago • 0 comments

I wish I could have captured the skittering but just too much wind

submitted 178 days ago • 25 comments

Do you know who Douglas Prasher is? Many don't, even though he is the person who cloned the original #GFP gene in the late 1980s. In my short history of plant light #microscopy I also cover a bit of his story - & why he is relatively unknown today, despite the importance of his work. See this 🧵👇

submitted 401 days ago • 3 comments

#moodboard

submitted 188 days ago • 25 comments

Cell and developmental biologists: as you start looking at conferences in 2025, consider joining us at the 2025 Cell Contact & Adhesion GRC. We've assembled a strong and diverse program of speakers at the cutting-edge of science in our field 1/n Please repost www.grc.org/cell-contact...

submitted 189 days ago • 2 comments

Have any of you successfully propagated a fig before? I have a fig that’s becoming too tall for my windowsill.

submitted 190 days ago • 10 comments

🚨📢Paper alert! Real progress on identifying why residual force enhancement occurs in skeletal muscle! This was a study I dreamed about since grad school. Please share! 🔬💪🧪 www.pnas.org/doi/10.1073/...

submitted 191 days ago • 1 comment

Three must read papers for PhD students. #scisky #PhD #science #research #academicsky 1. The importance of stupidity in scientific research Open Access journals.biologists.com/jcs/article/...

submitted 213 days ago • 58 comments

shrimply having a wonderful crustacean time

submitted 193 days ago • 9 comments

Someone asked me why sharks stick their dorsal fins out of the water. The answer is simple. Sharks’ dorsal fins stick out of the water sometimes because their fins are on top of and therefore higher than the rest of their body, and sometimes their body is near the surface of the water.

submitted 195 days ago • 49 comments

the tool of the elite bioinformatician

submitted 197 days ago • 12 comments

Also an RStudio Wrapped: which packages you used most frequently, most frequent error, etc!

submitted 202 days ago • 2 comments

Finally submitted my F31 proposal! Now to take a cue from Freckles and rest 😴

submitted 202 days ago • 0 comments

Trying out inverted 3-color lookup tables in FIJI today. Here is recruited RNA polymerase II (red), elongating RNA polymerase II (black-ish), and DNA (blue). Fixed zebrafish embryo nucleus recorded with iSIM @visitech.bsky.social Any suggestions for color combinations for three-channel composite?

submitted 203 days ago • 4 comments