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castellanoed.bsky.social

𝙴𝚟𝚘𝚕𝚞𝚝𝚒𝚘𝚗𝚊𝚛𝚢 biologist 𝚊𝚝 𝚝𝚑𝚎 𝚄𝚗𝚒𝚟𝚎𝚛𝚜𝚒𝚝𝚢 𝚘𝚏 𝙰𝚛𝚒𝚣𝚘𝚗𝚊 | 𝙼𝚞𝚝𝚊𝚝𝚒𝚘𝚗𝚜 𝙰𝚜𝚝𝚛𝚘𝚕𝚘𝚐𝚎𝚛 | 🅷🅰🆂🅷🆃🅰🅶🆂: #🆂🅲🅸🅴🅽🅲🅴 #🅱🅸🅾🅻🅾🅶🆈 #🅴🆅🅾🅻🆄🆃🅸🅾🅽 #🅿🅾🅿🅶🅴🅽 #🅼🆄🆃🅰🆃🅸🅾🅽🆂 https://msha.ke/dcastellano/

62 posts 146 followers 213 following

Posts 47 Comments 3

“The search for universal laws in biology similar to those in physics is futile, because the objects of biology—organisms—are products of unique historical trajectories.” Ernst Mayr (2004) What Makes Biology Unique?

submitted 2 days ago • 2 comments

It doesn't get reiterated enough that "human on a bicycle" is not only the most efficient way that a person can move, it's the most efficient form of motion ever observed in land animals.

submitted 11 days ago • 71 comments

Tuffaha, Wahl et al. analyzed tumors from 20 tissues to show that nonhypermutated tumors reverse germline mutation biases, facilitating adaptation without elevated mutation rates. 🔗 doi.org/10.1093/molbev/msaf105 ‪@ryangutenkunst.bsky.social @castellanoed.bsky.social

submitted 7 days ago • 1 comment

Researchers paid $9 billion over 5 years for their findings to be freely accessible. This is based on a study of the global expenditure on article processing charges (APCs) paid to six publishers for open access between 2019 and 2023. arxiv.org/abs/2407.16551

submitted 128 days ago • 2 comments

The primary energy fallacy is the idea that all primary energy from fossil fuels must be replaced with equivalent amount of clean energy. BUT: Not necessary because conversion losses don’t need to be replaced. 2/3 of all primary energy is lost as waste heat. knowledge.energyinst.org/new-energy-w...

submitted 17 days ago • 9 comments

The distribution of fitness effects varies phylogenetically across animals https://www.biorxiv.org/content/10.1101/2025.05.13.653358v1

submitted 20 days ago • 0 comments

I always thought that industry had limited electrification potential. How wrong I was: Once I looked into it in more detail I found that the potential is huge. 90% of industrial process heat could be electrified in Europe by 2035. That is what analysis for @agoraind.bsky.social says.

submitted 21 days ago • 1 comment

Episode 2 of our new podcast The Blind Spot with @adamfrank4.bsky.social and Marcelo Gleiser. www.youtube.com/watch?v=_XGa...

submitted 21 days ago • 1 comment

Come join us at Pioneer Works next week for Scientific Controversies: Aliens Adam Frank and David Kipping in Conversation with Janna Levin WEDNESDAY, MAY 28, 2025, 7:30PM @davidkipping.bsky.social @jannalevin.bsky.social pioneerworks.org/programs/sci...

submitted 22 days ago • 0 comments

I had to do it

submitted 46 days ago • 1 comment

TANK vs TESLA "We've crushed fascism before and we'll crush it again" - ⁠WW2 veteran Ken, 98, in the tank

submitted 27 days ago • 2311 comments

Neanderthal introgressed ancestry reveals human genomic regions enriched with recessive deleterious mutations https://www.biorxiv.org/content/10.1101/2025.05.07.652751v1

submitted 26 days ago • 0 comments

These boxes are not moving. A mind-bending optical illusion by Japanese artist Jagarikin.

submitted 28 days ago • 275 comments

How the Manosphere misuses Evolutionary Psychology open.spotify.com/episode/3Nfr...

submitted 29 days ago • 2 comments

Estimates of the Mutation Rate per Year Can Explain Why the Molecular Clock Depends on Generation Time academic.oup.com/mbe/article/... 🧪

submitted 31 days ago • 2 comments

Remember when you first learned about genetics at school? All those fascinating examples of human traits that are each apparently determined by just a single gene? Time to check in on some of your favourites to see how they’re doing. 🧬🧵🧪 1/n

submitted 32 days ago • 57 comments

How energy could be extracted from a black hole's rotation @juliangough.bsky.social arxiv.org/abs/2503.24034

submitted 32 days ago • 0 comments

submitted 34 days ago • 76 comments

ML, allele dominance, selection and fitness informing on #Neanderthal introgression by @klohmueller.bsky.social 🥰 🧬! #HumanEvo25

submitted 35 days ago • 1 comment

Kirk Lohmueller DominL uses patterns of archaic ancestry to infer degree of dominance. Provides statistical support for the presence of recessive deleterious mutations in the human genome. Up to 15% of the human genome may carry recessive deleterious mutations! 🧬 #HumanEvo25

submitted 35 days ago • 0 comments

Biology is the first half of the periodic table coming to life. Technology is the second half of the periodic table coming to life.

submitted 96 days ago • 0 comments

The rest of Mendel's alleles characterized! So, out of 7 traits, 3 caused by TE insertions!!! (though apparently there are two different green alleles, one cause by a TE insertion, but another a promoter deletion allele) www.nature.com/articles/s41...

submitted 38 days ago • 1 comment

Fun collaboration with Mélodie Bastian and Nicolas Lartillot. Pi_S and Pi_N/Pi_S extracted from genome assemblies follow nearly neutral predictions across 150 mammals. Getting closer to getting the constraint controls needed to detect ancient epidemics mammals-wide. www.biorxiv.org/content/10.1...

submitted 39 days ago • 1 comment

We might be in front of the Giordano Bruno of our age. Super interesting cosmological theory.

submitted 39 days ago • 0 comments

Beyond the big bang: Irishman’s universal evolution theory challenges accepted cosmology www.irishtimes.com/science/spac...

submitted 39 days ago • 2 comments

📣📣📣 PCI Plants @pciplants.bsky.social has been launched!!! @bourgeoisyann.bsky.social @mangolab.bsky.social @francoissabot.bsky.social @jorisbertrand.bsky.social

submitted 40 days ago • 0 comments

Human de novo mutation rates from a four-generation pedigree reference rdcu.be/ei55P

submitted 40 days ago • 1 comment

Vaccines save lives. Pass it on.

submitted 40 days ago • 5 comments

Enhancement of hidden Markov model analyses for improved inference of archaic introgression in modern humans https://www.biorxiv.org/content/10.1101/2025.04.22.649993v1

submitted 41 days ago • 0 comments

Early Birds get the best deal! 🐦✨ Are you passionate about evolutionary biology? Don’t miss the chance to register for ESEB 2025 at the exclusive Early Bird rate! Secure your spot 👉🏻https://eseb2025.com/registration/

submitted 41 days ago • 0 comments

The second workshop of our @eseb.bsky.social STN Internal Conflicts and Organismal Adaptation will take place at the Princess Hotel, Barcelona on August 17, during the day before the ESEB congress evening reception. More info and registration here: internalconflictsstn.wordpress.com/workshop-ii/

submitted 42 days ago • 0 comments

submitted 43 days ago • 241 comments

Overall, cancer cases and deaths in the US are continuing a slow decline acsjournals.onlinelibrary.wiley.com/doi/10.1002/...

submitted 43 days ago • 6 comments

Could JD Vance please also pray for the good health of Vladimir Putin?

submitted 43 days ago • 66 comments

By temporarily using more nuclear power (1-2 decades?), we could end the use of fossil fuels in the EU NOW, while increasing the installation of more renewables.

submitted 44 days ago • 1 comment

Unthinkable just 10 years ago: Almost 3/4 of the EU’s electricity in 2024 was from renewable energy sources and nuclear. Gas and coal electricity generation is at record low levels.

submitted 45 days ago • 44 comments

Here is our new podcast, The Blind Spot, with yours truly, @adamfrank4.bsky.social and Marcelo Gleiser at Spotify. open.spotify.com/show/5RWMnV4...

submitted 47 days ago • 3 comments

'We found a high probability of devil persistence over 50 devil generations (100 years) and a higher likelihood of devil–DFTD coexistence, with greater devil recovery than predicted by previous ecological models.' academic.oup.com/evolut/artic...

submitted 47 days ago • 1 comment

I've always wondered if I'd see such an event in my lifetime. I wish is not an artefact!!

submitted 47 days ago • 0 comments

Astronomers detected a possible signature of life on a planet orbiting a star 120 light-years away.

submitted 48 days ago • 110 comments

🌍 Evolve at #ESEB2025 in #Barcelona! 🧬 This August, don’t miss the chance for one of the largest gatherings in #EvolutionaryBiology in the vibrant city of #BCN! Enjoy discussions in the amazing backdrop of the mediterranean coast! 🎟️ Secure your spot 👉🏻 https://eseb2025.com/registration/

submitted 50 days ago • 0 comments

If someone tried to convince me that 14 edits to gray wolf genome makes the animal functionally dire wolf, I'd probably ask for a positive control: turn the wolf functionally jackal with just 14 edits. An easier task, and we at least know what jackals look like and how they act.

submitted 52 days ago • 1 comment

Looking at grant funding time for all years from 2015-2025 Here is the graph for new and competitive renewal grants (dollar amounts normalized by the overall NIH grant budget for each year_ 1/2

submitted 57 days ago • 3 comments

NBC News: A federal judge just issued a final judgement and permanent injunction against the Trump admin — ruling that the National Institutes of Health must continue funding research grants at their original, full amounts. @msnbc.com

submitted 59 days ago • 108 comments

Reality is not computation any more than it was the calculus of a mechanical clock centuries ago. Let’s not confuse our technology with what our universe is, it’s a surefire way to close the future by stifling our ability to see beyond the dogmas of our time. longnow.org/ideas/physic...

submitted 59 days ago • 12 comments

Holy shit--the tariffs are working. High-paying manufacturing firms are sprouting all over town. There's a little sapling industrial fabricator blooming in my backyard, offering $95k starting with a high school diploma. It looks so precious, glittering amongst the dew. The madman actually did it.

submitted 61 days ago • 234 comments

A Bayesian filtering method for estimating the fitness effects of nascent adaptive mutations https://www.biorxiv.org/content/10.1101/2025.03.29.646120v1

submitted 60 days ago • 0 comments