chasewnelson.bsky.social
HPV & evolution researcher 🧬 | Based in Taiwan 🇹🇼 & Michigan 🇺🇸 | Baritenor 🎶 | Reader 📚, writer ✍🏼, deadlifter 🏋🏼, espresso drinker ☕
1,012 posts
2,698 followers
471 following
Regular Contributor
Active Commenter
comment in response to
post
Deeply sad and moving, thank you so much for sharing
comment in response to
post
Just feathers is sufficient!
comment in response to
post
Thanks my friend! Greetings from the offshoot!
comment in response to
post
So many people for a little town!
comment in response to
post
No Kings in Holland, Michigan
comment in response to
post
No Kings in Holland, Michigan
comment in response to
post
Yay, so glad people are using it! Love the generosity on Bluesky
comment in response to
post
Yay, thanks for sharing! 🔥
comment in response to
post
My pleasure! Proud Lifetime Member—so glad to see SMBE and the journals on Bluesky!
comment in response to
post
Thanks to @evopaa.bsky.social for the update!
comment in response to
post
MPOX update out of Sierra Leone: "its health system is overwhelmed. The outbreak is driven by the variant called clade IIb, but is showing features previously associated with [clade Ib] — namely an explosive spread among both men and women". www.science.org/content/arti...
comment in response to
post
Thank you, friend!
comment in response to
post
Oof! I assume Covid (not the shot)?
comment in response to
post
Same! I was feverish at night (helped me sleep actually) and back to normal today
comment in response to
post
Thanks so much, friend! It's entirely self-serving—I hate being sick
comment in response to
post
Well put. I myself even wash my hands
comment in response to
post
It really is astonishing
comment in response to
post
Great Q and actually I'm not sure — I didn't ask for permission and just showed up! Given the wave, upcoming travel, and length of time since my own last 'boost' (via infection) I felt the balance was in favor of getting it. With 健保 it was NT$150
comment in response to
post
I'm not! Are you a user?
comment in response to
post
Friend, it brings me great joy to find there are still souls with a proper sense of humor
comment in response to
post
Same — one bout with a bad illness is enough to remind me what I'd rather miss!
comment in response to
post
Vaccines really are remarkable!
comment in response to
post
Thanks so much, friend!
comment in response to
post
COVID happens to be caused by an mRNA manufacturing machine that inhabits your body and churns out product for ten days—if you’re lucky.
Spike is but one of thirty odd proteins that may end up lodged in organs as distal as the toes, kidneys, stomach and brain.
Yes, I still prefer a jab in the arm.
comment in response to
post
Thankful for the healthcare system in Taiwan that makes this available.
Hoping to get a summer of infection protection from the antibody spike, and thankful for the memory cell boost after that. The immune system is amazing!
comment in response to
post
Please see the study for more details, including cataloguing of new sublineages and subclades in HPV45.
Huge congrats to the Mirabello lab — @lisamirabello.bsky.social @meredithyeager.bsky.social @michaeldeanlab.bsky.social et al. — and mentee Aimee Koestler for her first-author paper on HPV! 5/5
comment in response to
post
At a finer level, we also identified SNPs in the HPV45 genome associated with precancer/cancer risk.
One of these, T3556G, occurs in the genome region encoding both E2 and E4; causes amino changes in both; and results in higher stability of E2 than any other possible amino acid at its position. 4/5
comment in response to
post
The A1 sublineage of HPV45, most prevalent in sub-Saharan Africa, was used as a baseline.
Compared to A1, precancer/cancer risk is higher for sublineages A2 and B1. The A2 sublineage elevates risk particularly for women of Asian ancestry, among whom it has increased prevalence. 3/5
comment in response to
post
Each HPV type is often treated as a monolith—a single genetic entity with a given risk. But within-type variation can also matter.
Spearheaded by Aimee Koestler of the @lisamirabello.bsky.social lab, our study shows that viral genetic variation within HPV45 can influence cancer outcomes. 2/5