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dannimklee.bsky.social
Postdoc in Max Planck Institute for Molecular Genetics. PhD alumnus in Institut Curie. Epigenetics, dev bio, transcriptional regulation
6 posts 97 followers 74 following
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Posts 14 Comments 4

What controls condensate composition and function beyond binding stoichiometry? We show that condensate microenvironments play a key role, and can be probed by a micropeptide killswitch in live cells. www.nature.com/articles/s41... in @nature.com ‬ with @yaotianzhang.bsky.social Denes Hnisz & team.

submitted 3 days ago • 2 comments

Delighted to share a new preprint from the lab! We identified zinc-finger associated domain (ZAD)-containing C2H2 zinc-finger proteins (ZAD-ZnFs) as insulator-binding proteins in Drosophila. www.biorxiv.org/content/10.1...

submitted 17 days ago • 0 comments

Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇

submitted 17 days ago • 0 comments

Out @nature.com: Clonal tracing with somatic epimutations 🧬 Single cell methylome encodes cell state & clonal identity 🔨 EPI-Clone reads out both (+mutations, +RNA) at scale 🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations doi.org/10.1038/s415... 🧵

submitted 17 days ago • 7 comments

Excited to share a preprint from my lab on distinct specificity and functions of PRC2 subcomplexes: www.biorxiv.org/content/10.1...

submitted 22 days ago • 2 comments

I am thrilled to share our preprint where we take advantage of the unique opportunities offered by human blastoids to uncover a human-specific mechanism potentially playing a role in preimplantation 🧵. www.biorxiv.org/content/10.1...

submitted 26 days ago • 2 comments

Congrats to the very talented @oozguc.bsky.social 🔬

submitted 72 days ago • 0 comments

Happy to share the lab's latest publication from @eli-elder.bsky.social and team in @narjournal.bsky.social ! What happens when #DNAmethylation maintenance is transiently interrupted in mouse embryonic stem cells? Let's dive in (1/11). doi.org/10.1093/nar/...

submitted 100 days ago • 6 comments

1/ H3K27me3 mimicry has repeatedly emerged through evolution, but what's the physiological relevance? We show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2 in vivo and restrict the spread of Polycomb domains. 🧵 www.biorxiv.org/content/10.1...

submitted 85 days ago • 2 comments

Very happy that I attended the amazing SY-Stem symposium. I received so many nice feedback on my project and good to have another Curie BDD reunion. @deborahbourchis.bsky.social @dianapinheiro.bsky.social

submitted 84 days ago • 1 comment

The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋 The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...

submitted 142 days ago • 41 comments

Come to be our colleague @pasteur.fr! center of Paris, great colleagues, outstanding facilities, permanent position, crème brûlée every Friday - what else could one want?

submitted 182 days ago • 4 comments

🔺🔺🔺RED TRIANGLE ALERT 🔺🔺🔺 Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!! Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals! SMCs & RNA-Pol are the only thing they have in common www.nature.com/articles/s41...

submitted 191 days ago • 3 comments

Here it is! Congratuations to @jesskelley.bsky.social @edimitrova.bsky.social @neilblackledge.bsky.social @aleksszczurek.bsky.social and the rest of the team (Maciej, Amy, and Hieu). This was a fab collaboration with Arminja Kettenbach. Also see a lovely complementary paper from Fei Chen's group.

submitted 193 days ago • 8 comments