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Recent research connects RORγt⁺ APCs to food-specific pTregs in tolerance. But a new study from the Sakaguchi lab reveals these pTregs are short-lived and unstable potentially challenging existing models of oral tolerance. #immunology #tolerance #Foxp3 buff.ly/M1W6Ewl

submitted 3 days ago • 0 comments

Dear uLIPSTIC users, We have been getting reports that, under some more inflammatory settings like TB or chronic LCMV infection, uLIPSTIC-expressing lymphocytes adoptively transferred into cre-negative uLIPSTIC hosts may be rejected at later timepoints (>1 wk).

submitted 3 days ago • 1 comment

"It had planned to move the vaccine into later-stage trials with funding from the Department of Health and Human Services, but received notice that the agency was terminating its award." #moderna #mrna #vaccine buff.ly/7BMBCCW

submitted 4 days ago • 0 comments

🧠 New gut–microbiota-brain link found! "These T cells are primed in the periphery by the microbiome, and traffic from the white adipose and gastrointestinal tissues to the brain." "subfornical organ (SFO)" #microbiota #microbiome #gut #brain buff.ly/Txw3rkG

submitted 4 days ago • 0 comments

There’s been a wave of new research lately on RORγt⁺ APCs, pTregs, food tolerance, and the microbiota. Here’s the newest paper. #Tregs #Foxp3 #food #allergy #microbiota buff.ly/suXwcIW

submitted 5 days ago • 0 comments

“This means Harvard can no longer enroll foreign students, and existing foreign students must transfer or lose their legal status.” #Harvard #science Harvard University buff.ly/Z3XKMwr

submitted 10 days ago • 0 comments

"Here, we confirm profound diet-PI3K anticancer synergy but show that it is, surprisingly, unrelated to #diet macronutrient composition. Instead, the diet-PI3K interaction involves #microbiome metabolism of ingested phytochemicals." #cancer #tumor buff.ly/p015tY6

submitted 10 days ago • 0 comments

Dose-dependent platelet inhibition by icosapent ethyl contributes to beneficial effects of polyunsaturated omega-3 fatty acids www.science.org/doi/10.1126/...

submitted 11 days ago • 0 comments

1/ 🧪 The Rudensky lab never shies away from using cutting-edge gene tech to study Tregs. Their latest approach? Reversible protein degradation via ubiquitination. 👀 #Immunology #Tregs #science #Foxp3 www.researchsquare.com/article/rs-6...

submitted 11 days ago • 1 comment

This book offers a wealth of priceless historical and personal insight into Eastern Europe spanning nearly 1,000 years. However, the author defines its eastern edge as Ukraine, a view some countries may dispute. Highly recommended. buff.ly/1qX3spr

submitted 14 days ago • 0 comments

the funniest moment of Eurovision 2025 was when Italy's mouse avatar popped up and said, 'Our cheesy 12 points go to...'" 👍 😂 🐭 #Eurovision #Eurovision2025

submitted 15 days ago • 0 comments

Cataloging naturally occurring phenotypes and the underlying mutations that confer resistance in biomedically relevant contexts is one of the most important research areas the NIH should prioritize for funding. #NIH #JEM buff.ly/hHrcACg

submitted 16 days ago • 0 comments

"Ahrens-Nicklas had his genome sequenced. The test showed CPS1 deficiency" Is it now standard to do genome sequencing in newborns? How common is that? #crispr www.statnews.com/2025/05/15/c...

submitted 17 days ago • 0 comments

"Their research helped them create and win regulatory approval for a custom Crispr therapy for K.J. in six months" Wow, that was fast 'regulatory approval' by the FDA. #crispr buff.ly/alHqKTL

submitted 17 days ago • 0 comments

"Scientists have shown that a drug approved to treat migraine headaches can also alleviate debilitating non-headache symptoms, such as fatigue, brain fog and blinding light sensitivity, that occur as the migraine is starting." #ubrogepant #migraine buff.ly/5l71bUq

submitted 20 days ago • 0 comments

Th1 effector CD4 T cells rely on IFN-γ production to induce alopecia areata #immunology #alopecia buff.ly/kn8HC0O

submitted 22 days ago • 0 comments

🎬 OC REVIEWS: A haunting look at vanity, power, and uprooted trees — and how one billionaire’s private garden became a metaphor for a country being reshaped in his image. oc-media.org/review-tamin...

submitted 22 days ago • 0 comments

Pancreatic cancer–restricted cryptic antigens are targets for T cell recognition "Aberrant translation of the noncoding genome results in noncanonical (cryptic) peptides that can be processed and presented by HLA-I in pancreatic #cancer." #immunology buff.ly/YlcCtPc

submitted 24 days ago • 0 comments

When '(and here ask why)' is mistakenly assumed to be part of the abstract by the authors, editors, or even the AI assistant. #science #editing buff.ly/Zk7D6rg

submitted 32 days ago • 0 comments

"Analyses of antibiotic-treated and germ-free mice established that lung inflammation in the animals lacking IL-10 signaling was triggered by commensal bacteria." #microbiota buff.ly/VU0kjW0

submitted 33 days ago • 0 comments

This is another study highlighting the role of RORγt⁺ myeloid cells in food tolerance. However, some controversy remains, as a recent PNAS paper showed that RORγt⁺ APCs can either stimulate or tolerize T cells. #Foxp3 buff.ly/W76Xwfo

submitted 33 days ago • 0 comments

A possible way to eliminate bias in the selection process could be to implement a fully random system, such as a lottery. #science #STEM #academia buff.ly/HWsInsq

submitted 34 days ago • 0 comments

"Clonally matched antigen specificity between #Treg and Tconv wasn't required to prevent autoimmunity in steady state" it is because the polyclonal Treg pool already contains clones with TCRs cross-reactive to prostate C4 peptide, even without MJ23. buff.ly/CGyKaYG

submitted 36 days ago • 0 comments

Notable study. Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice—An unbiased functional study #immunology #autoimmunity #MS #microbiota ow.ly/68ia50VFPvn

submitted 37 days ago • 0 comments

Scientists say they can calculate the cost of oil giants’ role in global warming #science #carbon buff.ly/im2DeBW

submitted 39 days ago • 0 comments

@wyssinstitute and @emulateinc have teamed up again to create a super cool organ-on-#chip platform that mimics how our bodies respond to intramuscular mRNA #vaccines, enabling detailed testing without animals and speeding up vaccine development 🧬 @US_FDA buff.ly/VfyJQCz

submitted 42 days ago • 1 comment

GLP-1 meds like Ozempic and Wegovy lead to weight loss, but real-world results are less impressive than clinical trial outcomes. Average loss is only ~4–6% over 6 to 12 months. 📉💊 #Ozempic #Wegovy #GLP1 #WeightLoss buff.ly/s0fOYTN

submitted 42 days ago • 0 comments

📚 OC Reviews: Flight from the USSR — a fictionalised take on a harrowing attempt to escape Soviet Georgia. oc-media.org/review-fligh...

submitted 42 days ago • 0 comments

🎥 OC Reviews: Smiling Georgia — a tragicomic documentary on the wounds left behind by electoral theatre. oc-media.org/review-smili...

submitted 43 days ago • 1 comment

🧫💸 NIH = Not Investing in Health now. 🙃🚫🧠 "The proposal would reduce the more than $47 billion budget of the NIH to $27 billion" buff.ly/8BiKJzz

submitted 46 days ago • 0 comments

So who’s spreading H5N1 then — robots? "This dairy barn is full of cows, as you might expect. Cows are being milked, cows are being fed, cows are being cleaned up after, and a few very happy cows are even getting vigorously scratched behind the ears." buff.ly/p3Vrzeo

submitted 47 days ago • 0 comments

Like Harvard, Columbia University’s colonial charter predates the United States, and its independence is protected by the Constitution’s Contract Clause (Dartmouth College v. Woodward, 1819). #Harvard #Columbia #science buff.ly/FVF5yaf

submitted 47 days ago • 0 comments

Notable paper. "our findings suggest that enhanced TLR7 activity in predisposed individuals could confer innate, pDC-mediated, sterilizing immunity to SARS-CoV-2 infection, with I-IFN–driven chilblains as a trade-off." #COVID19 #SARS_COV2 #Type_I_IFN buff.ly/KG6WQVd

submitted 47 days ago • 0 comments

Wow, we are now being officially advised against travel to the USA by the Canadian Association of University Teachers. I never thought I'd see the day. ☹️ #AcademicChatter

submitted 47 days ago • 211 comments

Harvard’s colonial charter predates the U.S., and its independence is shielded thanks to the #Constitution’s Contract Clause (Dartmouth, 1819). 🤔 Wonder how far #federalfunding cuts can really shape university policies? www.nytimes.com/2025/04/14/u...

submitted 48 days ago • 0 comments

According to the Georgian TV channel Formula, citing an anonymous source, Vakhtang Gomelauri is expected to resign as Interior Minister and will be replaced by the leader of the parliamentary majority, Mamuka Mdinaradze. oc-media.org/tv-formula-s...

submitted 48 days ago • 0 comments

Are we witnessing the U.S. #biotech apocalypse? "So where are the jobs going? In a word, China." Drugs in Development 2014: China: <500 drugs U.S.: ~6,000 drugs 2024: China: >6,000 drugs U.S.: <9,000 drugs Even at 200% tariff, China’s cheaper. bostonglobe.com/2025/04/14/b...

submitted 48 days ago • 0 comments