denard.bsky.social
Evolutionary Biologist. Ancient epidemics. Genomic adaptation.
110 posts
1,277 followers
266 following
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You might as well have written, "we sat HDCs at a terrace in Paris".
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I wrongly thought that I should not include them, but after seeing a number of application images I started wondering if I had been too conservative.
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Thank you Harmit!
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The question of selection during the Black Death will likely require a Yersinia pestis-human-host interactome. Looking at selection at human YIPs (Yersinia-interacting proteins) should be more specific and powerful than immune genes in general. Population genetics in a silo can only go so far.
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Looking at the response below, it seems that the functional results with ERAP2 just cannot be dismissed so easily. I am also wondering what qualifies as a detectable change in frequency under very stringent filters with a high risk of false negatives?
www.biorxiv.org/content/10.1...
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This was also a very insightful publication by collaborator @smiao.bsky.social et al. Things are complex in humans and indeed the straightforward approach that was used in drosophila cannot work:
pmc.ncbi.nlm.nih.gov/articles/PMC...
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2/2) I have moved on from this a long time ago. In fact, you can use sweeps in humans to not only detect but even date past evolutionary events such as ancient epidemics. The common/rare debate has IMO become irrelevant in that respect, we can tie sweeps to cool biology.
www.cell.com/current-biol...
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Such a blast to collaborate w. Enard & Sudmant Labs: #IRP #IRC @cnrsbiologie.bsky.social @cnrswashington.bsky.social @ucberkeleyofficial.bsky.social @uarizona.bsky.social
partnership!
Special thanks to Elise Lauterbur @lauterbur.bsky.social & Manny Vazquez⭐
@denard.bsky.social @psudmant.bsky.social
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The conversion to jpeg helped with the noise, it was more visible in the raw, but still very acceptable.
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Sony a7rv with a Tamron 28-200 zoom lens, handheld. I did not shoot for ~15 years, I am shocked by the amount of technological progress made.
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I see that they were careful to compare the same set of five traits. The second question is then if within-family really accounts better for the environment?
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Could it be that within-family GWAS are biased for example towards immune traits where faster evolution is expected?
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Spread the word that I have a postdoc opening right now, and am also open to PhD applications evol.mcmaster.ca/brian/evoldi.... We have lots of follow up ideas! 15/15
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Thank you!
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Good luck with seagulls and cleaning that window...
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My high school biology teacher who told me to consider trying the Ecole Normale Supérieure exam, passed away in an accident months ago, and I am still upset about it. He was aloof and not approachable, but made the thought not feel so outlandish and totally out of reach from my small rural town.