dnatopologylab.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

Happy birthday, Dad. Time to come back now, it’s all gone a bit rubbish without you. ❤️❤️❤️

submitted 25 days ago • 229 comments

3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴󠁧󠁢󠁳󠁣󠁴󠁿 www.biochemistry.org/events-and-t...

submitted 38 days ago • 0 comments

Fresh of the press! rdcu.be/egmY0 We discovered key chromatin modifications that are heritably maintained through mitotic cell divisions in the absence of continued transcription. These hold a memory of past exposure to interferon-gamma, priming cells for future activation of gene expression.

submitted 49 days ago • 1 comment

A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.

submitted 56 days ago • 0 comments

Very pleased to share our new story on SMC complexes, a great team effort from @roisnehamelinf.bsky.social, @taschner.bsky.social in the GruberLab and James of @dnatopologylab.bsky.social We find that SMC hinge domains are ssDNA gates to facilitate obstacle bypass during DNA loop extrusion!

submitted 66 days ago • 2 comments

The lab is on 🔥 Tour de force by Hon, Florian and Taschi! Bravo! Privileged to have played a tiny part in this amazing story!

submitted 66 days ago • 1 comment

Glad to share the work of @yli18smc.bsky.social and co on Lamassu, a bacterial defense system related to Rad50/Mre11 (RM). While RM carefully trims DNA ends for repair, Lamassu chops up the host chromosome. Our study reveals how it is regulated to minimize damage, activating only during infection.

submitted 68 days ago • 4 comments

Happy to share the beautiful structure of a Wadjet SMC complex by @roisnehamelinf.bsky.social, with support from the DCI and @drhonsworth.bsky.social ! This is a type II Wadjet with unique characteristics including a tandem KITE subunit, distinct coiled coil architecture and a deviant hinge.

submitted 73 days ago • 1 comment

A new PhD position is available in my lab to explore DNA replication mechanisms using single-molecule approaches. Apply by 19th of March: www.crick.ac.uk/careers-stud...

submitted 80 days ago • 0 comments

Fantastic opportunity to work with an amazing team in a world class setting. Apply!!

submitted 80 days ago • 0 comments

Amazing opportunity. Peter is super cool. Apply!

submitted 85 days ago • 0 comments

A brilliant, kind, funny colleague gone too soon. We will miss you Bela. www.merton.ox.ac.uk/news/remembe...

submitted 87 days ago • 0 comments

Tenured full Professorship in Genetics and Molecular Cell Biology at the University Of Cologne, Germany It's an opportunity to rebuild the place that used to be home to luminaries including Benno Müller-Hill, Max Delbruck, Campos-Ortega, Diethard Tautz Maria Leptin, Thomas Langer

submitted 88 days ago • 3 comments

Excited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%) We quantify mESC 36k loops: <loops> are generally rare (2.3%) www.biorxiv.org/content/10.1...

submitted 127 days ago • 6 comments

Our new review on how the #chromatin domain is formed in the cell is now available @Curr Opin Struct Biol.📄✨ We critically discuss the domain formation mechanism from a physical perspective, including #phase-separation and #condensation. 📥 Free-download link: authors.elsevier.com/a/1keGn,LqAr...

submitted 92 days ago • 0 comments

🎯Breaking News Enzyme used in meiosis makes the cut in vitro News www.nature.com/articles/d41... Paper 1 doi.org/10.1038/s415... Paper 2 doi.org/10.1038/s415... Paper 3 doi.org/10.1038/s415...

submitted 92 days ago • 0 comments

Our preprint on atomistic modelling of the Campylobacter jejuni lipidome is out!

submitted 94 days ago • 1 comment

The Barr lab @ox.ac.uk has discovered the important role of cell division timing mechanisms in the formation of cancer. The research, funded by Cancer Research UK, provides valuable insight into how damaged cells are normally stopped from growing. ⬇️ bit.ly/202502-barr

submitted 100 days ago • 0 comments

🧬🧪🦠🧫 @science.org www.science.org/doi/10.1126/... @rkoszul.bsky.social @leameneu.bsky.social @christophechapard.bsky.social @chromozz.bsky.social @pasteur.fr @sorbonne-universite.fr @institutcurie.bsky.social + PS www.science.org/doi/epdf/10.... @gfudenberg.bsky.social @vram142.bsky.social

submitted 104 days ago • 0 comments

Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin? By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient! #chromatin #3Dgenome #generegulation www.science.org/doi/10.1126/... 👇

submitted 105 days ago • 3 comments

Why do different DNA molecules occupy different places in the nucleus? What drives chromatin compartmentalisation? Read this amazing paper to find out www.science.org/doi/10.1126/... Many congratulations to all the authors of this brilliant work! @rkoszul.bsky.social

submitted 105 days ago • 0 comments

Does anyone else agree? We do: “Bluesky is much better for science. There is much less toxicity, misinformation, and distractions,” wrote one respondent. My feed is almost entirely scientists and I actually get updates on research that is relevant and timely” www.nature.com/articles/d41...

submitted 114 days ago • 0 comments

ICYMI We are recruiting a new Associate Professor in cell and molecular biology, with a preference for immunology, inflammation and/or infection - all defined broadly Come and be our colleague! Deadline 28 Feb, please spread the word! www.path.ox.ac.uk/vacancy/asso...

submitted 121 days ago • 0 comments

Some exciting news, folks. @timcoulson.bsky.social and I have a new science podcast launching soon. Please do follow the account for updates. More details coming very soon!

submitted 117 days ago • 0 comments

Fabulous work from our colleagues in the Barr lab showing how the CPC binds the nucleosome! www.biorxiv.org/content/10.1...

submitted 120 days ago • 0 comments

Friendly reminder of our webinar next Tuesday! See you all there!

submitted 119 days ago • 0 comments

Three-dimensional organization of amoeba Dictyostelium discoideum has fascinating features! Very prominent dots at between convergent gene positions, something never really seen for other species. More about the puzzle and how the team of my PhD colleagues resolves it: doi.org/10.1093/nar/...

submitted 119 days ago • 0 comments

Radical blow to biomedical science in the US due to Trump administration decrees: www.science.org/content/arti...

submitted 120 days ago • 2 comments

If you're interested in chromosome biology (DNA folding, gene regulation, replication, polymer modelling and more) we're organising the below this autumn. It'd be great to see you there. Please share if you can. :-)

submitted 122 days ago • 0 comments

The plasmids described in our recent ‘4G-cloning’ paper for multi-subunit complex expression (www.life-science-alliance.org/content/8/1/...) are now available from @addgene.bsky.social (www.addgene.org/search/catal...). Thanks to Addgene for distribution in this convenient and affordable format!

submitted 120 days ago • 2 comments

Grateful for the opportunity to contribute a little to this great study! Step by step we are beginning to understand how these wonderful machines work....

submitted 126 days ago • 1 comment

The Royal Society's Newton International Fellowships will open for applications next week on 21 January. These fellowships are for non-UK early career scientists who wish to conduct research in the UK. Find out more on our website: #RSGrants royalsociety.org/grants/newto...

submitted 129 days ago • 3 comments

There's nothing more reassuring than knowing that everything is running just as it should be across our glorious Transport for London network.

submitted 144 days ago • 0 comments

Wishing everyone who celebrates a very Merry Christmas.

submitted 151 days ago • 0 comments

In our latest mini review, Toni Valdes and I discuss the potential role(s) of DNA superhelicity in the organization of chromosomes by SMC protein complexes, covering classical biochemistry experiments to recent single-molecule biophysics studies. doi.org/10.1042/BST2...

submitted 155 days ago • 0 comments

Please RT: Associate Professor position in my department at the University of Oxford. Broad search in molecular and cellular biology: my.corehr.com/pls/uoxrecru...

submitted 158 days ago • 1 comment

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute. Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now! 3 postdoc positions advertised soon.

submitted 163 days ago • 17 comments

Yesterday, #DemisHassabis delivered his #Nobel Prize Lecture & referenced a paper on 1st contact between egg and sperm by our @pauligroup.bsky.social, @vdeneke.bsky.social, Andreas Blaha, et al. The study was highlighted as a user case for #AlphaFold - how cool! See: www.youtube.com/live/HnT1VWz...

submitted 165 days ago • 0 comments

Our work on SMC Wadjet is finally out! Congrats to all co-authors!

submitted 171 days ago • 1 comment

We are seeking a motivated postdoc to join our lab! Our research focuses on live-cell imaging/analysis to reveal how chromatin behaves in living cells and how its behavior contributes to cellular functions. www.nature.com/articles/s41... www.science.org/doi/10.1126/... Interested? Please DM me!

submitted 174 days ago • 2 comments

The Vienna Biocenter Summer School 2025 call is now open for talented undergrads, it's a great prog. for students who are interested in the life sciences. training.vbc.ac.at/summer-school/ @impvienna.bsky.social @imbavienna.bsky.social @gmivienna.bsky.social @maxperutzlabs.bsky.social

submitted 175 days ago • 0 comments