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drdanbrierley.bsky.social
Gut-Brain Neuroscientist & New PI | Wellcome Trust Sir Henry Dale Fellow | Group leader of UCL Gut-Brain Neurophysiology & Ingestive Behaviour lab | http://brierley-lab.org
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From today, every paper submitted to Nature -if published - will be accompanied by peer reviewers comments & authors rebuttal. We started the trial in 2020; we now want to open up the review process & showcase its role in shaping & improving papers 🧪 #AcademicSky www.nature.com/articles/d41...

As we head to the 2025 @amdiabetesassn.bsky.social GIP biology will be part of the conversation. Here Samms and Sloop summarize the compelling scientific story of Tirzepatide and the case for GIPR co-agonism #Diabetes #Weightloss #obesity diabetesjournals.org/diabetes/art...

Beautiful! Going to have to give this a try asap

Our work, out at Cell, shows that the brain’s dopamine signals teach each individual a unique learning trajectory. Collaborative experiment-theory effort, led by Sam Liebana in the lab. The first experiment my lab started just shy of 6y ago & v excited to see it out: www.cell.com/cell/fulltex...

Metsera highlights Placebo-subtracted mean weight loss up to 8.4% at Day 36 for after weekly dosing of the potentially once-monthly Amylin candidate MET-233i investors.metsera.com/news-release...

🍽️ New study shows that “mini-ghrelins” (short peptides from ghrelin breakdown) can bind and block the ghrelin receptor without triggering its effects. Instead of being inactive leftovers, they may actively inhibit ghrelin’s hunger-inducing actions. #neuroskyence #science #ingestivebehavior

Excited to share our Science paper on HaloDA1.0-the first genetically encoded far-red dopamine sensor! 🥳It enables powerful multiplex imaging in neurons, brain slices, and live animals.🧠🔬 #GRABsensors #Dopamine www.science.org/doi/10.1126/...

Join the UKDRI at UCL in the Salih Lab to explore how glial-specific longevity genes affect ageing and Alzheimer’s, using iPSC models, genomics, and molecular biology @ukdri.ac.uk @dervissalih1.bsky.social Closing date: 26th June www.dementiaresearcher.nihr.ac.uk/job/research...

Finishing your undergraduate and interested in neuroscience research? The Neuroscience streams of our Biosciences MRes degree provide a unique opportunity to conduct a year-long research project in any UCL neuro lab, plus taught modules to prepare you for a PhD. 🧪🧠📈 www.ucl.ac.uk/biosciences/...

Finishing your undergraduate and interested in neuroscience research? The Neuroscience streams of our Biosciences MRes degree provide a unique opportunity to conduct a year-long research project in any UCL neuro lab, plus taught modules to prepare you for a PhD. 🧪🧠📈 www.ucl.ac.uk/biosciences/...

🚨 Paper alert! 📣 We found abnormal feeding-related neural responses in satiety-promoting, MC4R-expressing neurons in the mouse paraventricular hypothalamus (PVH-MC4R) following diet-induced obesity. www.biorxiv.org/cgi/content/... ​​ #obesity #feedingbehaviour #obesityresearch #neuroscience

Register to our Neurometabolism Summer Seminar Series and don't miss our first seminar by Dr. Martin Myers on "CNS control of food intake an metabolism". Lila Dabill from Washington University will be our student presenter. Register here: forms.gle/nvcWTK7BtwSj... #Science #Metabolism

Have you ever used a genetic tool and wondered what transcriptomic cell types it actually labels in the brain? Now is your chance to help solve this problem, through our MapMySections data challenge! 🧠📈 Submit your algorithm by May 30. alleninstitute.org/events/mapmy...

Paracetamol works by targeting the endocannabinoid system? Cool finding!

This summer, we're working on documenting setups and protocols for using popular tools such as SLEAP, Bonsai, & ArUco marker tracking. You can read about our plans in this week's post and stay tuned for updates over the summer! #OpenScience #Neuroscience edspace.american.edu/openbehavior...

Excited to share our latest story: "The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events" 🎉. Big congrats to 1st author Oriane Onimus 💪 🥳 & many thanks to all those involved 🙏🙏. www.biorxiv.org/content/10.1...

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

Article from Zoe Williams in today’s Guardian about our panel discussion on GLP1 drugs for obesity at British Library. www.theguardian.com/commentisfre...

📢 Fantastic post doc job opportunity in my group and co-supervised by DeepMind's @mariaeckstein.bsky.social - now live! Ad here: tinyurl.com/26rafzdc - deadline May 29th. This is part of a very exciting collaboration with @melgaby.bsky.social and Matt Nour, funded by @wellcometrust.bsky.social.

"Hedonic Foraging" - a free energy model of wanting and liking www.biorxiv.org/content/10.1... I love this Figure 1, we need more emojis in science - the full gamut from 😀to 🤡

Join the @ukdri.ac.uk at UCL as a Senior Animal Lab Technician—support dementia research through expert care of transgenic mice and collaborative lab work. Closing date: 1st June www.dementiaresearcher.nihr.ac.uk/job/senior-a...

NEWS&VIEWS | S Pereira and MK Hahn (@uoft.bsky.social) Glucagon-like peptide-2 (GLP-2) minimizes metabolic disruptions caused by the antipsychotic olanzapine.

Have you submitted your abstract for #BSNBradford2025 yet? Deadline is 31 May! Symposia: Endocrine disruption by environment Rhythms and hormonal interaction Beyond traditional models in neuroendocrine research Neuroendocrine links to dementia Join us: https://bit.ly/3WS2zHy

How does this magic work? bsky.app/profile/did:... - like this is some great magic!

🧪Hello! are you a scientist who started your PhD in 2020 and are now wrapping up? I want to know how your life is and how you're feeling about your prospects in 2025 for a story in @nature.com. DM me or find me on Signal at aheidt.16. Tell yo friends! (Also seeking international sources.)

I'm excited to share our recent review on lateral hypothalamus and eating: cell types, molecular identity, anatomy, temporal dynamics and functional roles. www.nature.com/articles/s12...

Our latest review, led by @anikavear.bsky.social with Michael Heneka, explores the emerging role of incretin-based therapies in neurodegenerative disease treatment www.nature.com/articles/s42...

Are you a postdoc or student working on a neuroendocrine research project? Get up to £8,000 support for consumables/other research costs to enable you to carry out the best possible neuroendocrine research project. Deadline 2 June 2025 Apply: www.neuroendo.org.uk...

A pleasure to share the latest ECR perspective published in @jne-editor.bsky.social from Naresh Hanchate at UCL - “Single-cell genomics meets systems neuroscience: Insights from mapping the brain circuitry of stress” onlinelibrary.wiley.com/doi/full/10....

KYNA acts through the GPR35 receptor to inhibit vagal afferent signaling and subsequently activate ARCAgRP neurons, which leads to increased food intake #microbiota @cp-cellreports.bsky.social www.cell.com/cell-reports...

Beautiful work - straight to top of journal club list!

👇👇 Awesome opportunity! 👇👇

👇Don’t miss the fantastic symposia @ #SSIB2025👇 GLP-1R Agonists: What Can We Learn From These Drugs? hear the latest from: Ralph DiLeone · Jessica Matheus Sa · Mette Kruse Klausen 🗓️ July 28–Aug 1 · 📍Oxford 👉 Register: www.ssib.org/2025/registr... #SSIB2025

New preprint from former lab member Joe Bedont on Bmal1 in hypothalamus tanycytes. Tanycyte-specific loss of function of Bmal1 inhibits both weight gain on high-fat diet and tanycyte-derived neurogenesis. www.biorxiv.org/content/10.1...

New insights into the actions of GIP agonism vs. antagonism on food intake and body weight in mice from Timo Muller and colleagues #weightloss #obesity @naturemetabolism.bsky.social www.nature.com/articles/s42...

The lasting damage that the Trump administration is doing to US science is barbaric. But more and more of the general public is hearing about it and just how bad it is:

Convergence and consensus www.science.org/doi/10.1126/...

Join us at British Library on-line or in person Fri 9th May 7pm to hear me @zoesqwilliams.bsky.social @kimberleywilson.bsky.social @christinaavogel.bsky.social discuss GLP-1 based therapies for obesity 🥗🍰. Tickets via: events.bl.uk/events/ozemp... @imperialbrains.bsky.social @imperialmed.bsky.social