duderstadtlab.bsky.social - Profile | ThreadSky | a Reddit-style client for Bluesky

We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social! www.biorxiv.org/content/10.1... #Chromatin #Asgard #Archaea #cryoEM

submitted 12 days ago • 12 comments

Our new study of chromatin ubiquitylation by variant PRC1 on the single-molecule scale: We visualize directly how vPRC1 ubiquitylates neighboring nucleosomes during a single binding event, showing a potential mechanism how H2Aub domains are established. www.science.org/doi/10.1126/...

submitted 17 days ago • 2 comments

Excited to share our new preprint on HLp—a bacterial histone from Leptospira perolatii that forms stable tetramers and wraps ~60 bp of DNA: "DNA Wrapping by a Tetrameric Bacterial Histone" www.biorxiv.org/content/10.1... @mpi-bio-fml.bsky.social

submitted 26 days ago • 4 comments

Very excited to present our latest work: SPINNA, an analysis framework and software package for single-protein resolution data! 🖥️🤩 We can directly quantify stoichiometry and oligomerization from super-res (DNA-PAINT, RESI) images!! 🧬🎨

submitted 31 days ago • 0 comments

📢Stigler lab in collaboration with the Holt lab decipher that LINE-1 ORF1p forms super-saturated co-condensates with RNA that enable DNA binding and nuclear entry during mitosis. Congratulations!👏👏👏 Details: www.science.org/doi/10.1126/...

submitted 32 days ago • 0 comments

Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....

submitted 34 days ago • 2 comments

3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴󠁧󠁢󠁳󠁣󠁴󠁿 www.biochemistry.org/events-and-t...

submitted 53 days ago • 0 comments

Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv

submitted 57 days ago • 12 comments

🚨New preprint🚨We developed a transverse flow imaging approach to directly visualize bacterial replisomes challenged by topological barriers and discovered a fast rotational mode of replisome operation. Fantastic work by thomasmretzer.bsky.social and Hamdan Lab! tinyurl.com/replisomerot...

submitted 59 days ago • 1 comment

🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome

submitted 62 days ago • 10 comments

I ❤️ this new paper on RAD52 at replication forks, just published @nature.com. Cryo-EM reveals a unique double-ring structure that blocks reversal of replication forks. www.nature.com/articles/s41...

submitted 64 days ago • 1 comment

How do SMC complexes capture DNA? 🧪 Led by Frank Bürmann, Jan Löwe’s & Mark Dillingham’s groups have identified the directional loading mechanism the bacterial SMC complex MukBEF uses to capture & ingest DNA, & found a phage inhibitor to this pathway. Read more: tinyurl.com/4s8nrrkk #LMBResearch

submitted 68 days ago • 1 comment

Our Lise Meitner Research Group Leader Maria Sokolova receives this year's Heinz Maier-Leibnitz Prize 2025 for her outstanding research on bacteriophages. Congratulations!🥳 ❕ www.dfg.de/de/service/p... #Award, #WomenInScience, #bacteriophages @arimiora.bsky.social @maxplanck.de

submitted 71 days ago • 3 comments

🚨New paper🚨Our new study with the lab of Phil Cole uncovers how SIRT6 dynamically adapts structurally and enzymatically to target diverse histone acylations (e.g., H3K27ac) within nucleosomes. @jonmarkert.bsky.social doi.org/10.1016/j.jb... #Chromatin #SIRT6 #CryoEM

submitted 71 days ago • 2 comments

🤩Save the date: Marieke Oudelaar will speak on Molecular Drivers of 3D Genome Folding and Their Function in Gene Regulation💬 We look forward to meeting @mariekeoudelaar.bsky.social😆 Join us on April 8 at 1:30 pm🤗 ➡️Lynen Lecture Hall @mpi-nat.bsky.social

submitted 72 days ago • 0 comments

Check out our review on DNA end resection! With Raphael Ceccaldi, www.nature.com/articles/s41...

submitted 74 days ago • 2 comments

Happy to announce that our new work on studying how gliding diatoms modulate the curvature of their paths is now on #bioRxiv www.biorxiv.org/content/10.1.... Great work in collaboration with @nic-poulsen.bsky.social on a nucleation grant by @poldresden.bsky.social #OpenScience #Preprints #diatom

submitted 79 days ago • 2 comments

Labeling your axes and then explaining them slowly is perhaps the biggest bang for the buck you can get for making your slides more understandable.

submitted 87 days ago • 5 comments

As some of you already know, I was appointed Dean of Science at Columbia in December and began my role on Jan 1. It’s an honor to support our students, postdocs, and faculty—especially in this challenging moment. Science at Columbia is strong. #ColumbiaScience fas.columbia.edu/news/ruben-g...

submitted 87 days ago • 12 comments

I wrote an opinion piece for my hometown South Carolina newspaper that was published today. Support science funding for our future! Standing up for science today and always! tinyurl.com/mr3vuphr

submitted 92 days ago • 0 comments

How do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!

submitted 93 days ago • 8 comments

𝐍𝐞𝐰 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐭𝐢𝐜 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐢𝐧𝐭𝐨 𝐭𝐡𝐞 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐡𝐢𝐬𝐭𝐨𝐧𝐞 𝐬𝐮𝐩𝐩𝐥𝐲! Excited to share our latest collaboration led by tkjeong.bsky.social and ciaranfrater.bsky.social! Structural determination of the histone chaperone ASF1 and its regulator CODANIN-1 uncovers how CODANIN-1 counters ASF1 activity. 🧵👇

submitted 93 days ago • 1 comment

#pictureofthemonth: Illustration of combined histone proteins (center) so a DNA thread (foreground) can wind around them like a spool. www.biochem.mpg.de/duderstadt March – institute calendar of @mpibiochem.bsky.social and @mpiforbi.bsky.social Image by Karl Duderstadt @duderstadtlab.bsky.social

submitted 93 days ago • 0 comments

A new PhD position is available in my lab to explore DNA replication mechanisms using single-molecule approaches. Apply by 19th of March: www.crick.ac.uk/careers-stud...

submitted 95 days ago • 0 comments

Amazing news on thr #Fiji front. The new launcher holds beautiful promises for better bioimage analysis tools, and not only for Fiji!! See this summary thread by Curtis forum.image.sc/t/fiji-2024-...

submitted 98 days ago • 0 comments

SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026. Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute). www.embl.org/about/info/c...

submitted 101 days ago • 1 comment

Proud to share our latest publication in @narjournal.bsky.social! A fantastic team effort led by @marcelwerner.bsky.social and Manuel T., where we explore the chromatin dynamics at transcription-replication conflicts (TRC) sites and their impact on genome stability using a novel TRC reporter system.

submitted 107 days ago • 3 comments

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇

submitted 108 days ago • 5 comments

Meet Carina Baer de Oliveira Mann, our newly appointed professor of #Biomolecular Cryo-Electron Microscopy, in the latest NewIn episode. She aims to identify #molecularswitches in the human #immunesystem that activate the immune defenses: go.tum.de/157504 @oliveiramann.bsky.social 🎥ProLehre

submitted 107 days ago • 0 comments

The UK&Ireland single-molecule meeting 2025 will be held in Oxford on May 14 and 15 - deadline for abstract submission March 7 - submit one and join us! Here is the link: lumicks.com/uk-single-mo...

submitted 110 days ago • 0 comments

🌟 <interact> 2025 Registration Now Open! 🌟 Prepare to meet our fantastic keynote speakers while enjoying inspiring networking with the participants 🧬✨ Explore and celebrate the impact of our research on the world around us alongside like-minded scientists. Let the <interact>ion begin!!

submitted 129 days ago • 1 comment

Join our online information session re. our 2025 round for Fellows at Oxford Biological Physics (original ad below)! Date: Jan 30, 2025 Time: 11 am -12 noon UK time Location: Online via Zoom (rsvp by Mon 27/1/2025 at [email protected]) Oxford Biological Physics Faculty

submitted 135 days ago • 0 comments

Opening for a senior postdoc in our single-molecule DNA replication lab! Deadline January 15, 2025!

submitted 177 days ago • 1 comment

Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of @jonmarkert.bsky.social! tinyurl.com/setd2

submitted 177 days ago • 21 comments

Our work on SMC Wadjet is finally out! Congrats to all co-authors!

submitted 186 days ago • 1 comment